Abstract
IntroductionNaturally, in human body, there is a balance between free radicals and the antioxidant system. Yet, cigarette consumption in smokers increases free radicals and decreases antioxidants. A vast body of research showed that the ROS level of seminal fluid is reduced using oral antioxidant complements through enhancing the clearing capacity of free radicals. Thus, the present research aimed to explore the effect of vitamin complement consumption on changing male infertility indices among smokers.MethodsIn the present randomized clinical trial which was single-blinded, 50 infertile oligospermic and asthenospermic men participated. They were selected in a randomized convenient sampling method. Before the study began, a semen sample was taken from all participants for analysis. Subsequently, the patients received 30 mg of Q10 coenzyme, 8 mg of zinc, 100 mg of vitamin C, 12 mg of vitamin E, 400 mg of folic acid for a whole duration of 3 months on a daily basis (once a day) and 200 mg of selenium every other day after lunch. A second sample of seminal fluid was taken from patients and semen parameters were compared between the pre- and post-test. The relevant statistical analyses were conducted in SPSS.23.ResultsA comparison of pre-test and post-test results revealed that all sperm parameters including the volume, morphology, motion, count and progressive motility were significantly increased after the intervention (p ≥ 005). Moreover, a statistically significant improvement was observed in the pH and concentration of seminal fluid.ConclusionThe present research showed that consuming vitamin complements (30 mg of Q10, mg of zinc, 100 mg of vitamin C, 12 mg of vitamin E, 400 mg of folic acid) once a day as well as 200 mg of selenium every other day can effectively improve the qualitative parameters (pH and concentration) and quantitative parameters (volume, motion, morphology, count and progressive motility) in infertile male smokers.
Highlights
In human body, there is a balance between free radicals and the antioxidant system
A comparison of pre-test and post-test results revealed that all sperm parameters including the volume, morphology, motion, count and progressive motility were significantly increased after the intervention (p ≥ 005)
The present research showed that consuming vitamin complements (30 mg of Q10, mg of zinc, 100 mg of vitamin C, 12 mg of vitamin E, 400 mg of folic acid) once a day as well as 200 mg of selenium every other day can effectively improve the qualitative parameters and quantitative parameters in infertile male smokers
Summary
Infertility implies inability to conceive after at least one year of unprotected intercourse [1]. Smoking can increase free radicals and decrease antioxidants [5]. Their research findings revealed that smoking affected sperm motion and count negatively. This negative effect on the former exceeded that of the latter. Several studies showed the positive effects of selenium in a proper dosage on the quality of sperm specially sperm count, motion and morphology. Among these studies was the work of research by Macpherson et al who reported that selenium could positively affect sperm motion in infertile men [12]. Considering the great number of infertile male smokers in community and due to the very limited number of quantitative studies concerning the effect of oral vitamins on semen parameters in infertile male smokers, the present research intended to explore the effect of oral vitamin complements on changing fertility indices in male smokers of Bandar Abbas
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