The paleoclimate since the late Pleistocene has gained substantial attention due to its profound effects on hydrology, ecosystems, and landforms, particularly in regions experiencing permafrost thawing. Northeast China is acknowledged for exhibiting distinctive yet contentious paleoclimate, which has been elucidated through various proxies. In this case, we emphasize the significance of stable isotopes within the northern Songnen Plain as complementary proxies for paleoclimate interpretation, bolstered by radiocarbon dating. The Cretaceous sandstone confined aquifer (CSA) is designated as the reference aquifer, based on the hydrogeochemical and isotopic characteristics. The 14C results indicate that the CSA preserves groundwater from the late Pleistocene to the modern. These findings, in conjunction with isotope variations, delineate specific climate events, which are aligning with results derived from conventional proxies. The late Pleistocene-early Holocene showed a climate shift from cold to warm. The middle Holocene was warm and humid. Then the late Holocene entered the Neoglacial, which characterized by a cold climate environment. Our analysis also reveals fluctuations in the age and TDS concentration along the groundwater runoff. The paleo groundwater exhibits simultaneous lower TDS concentration, maximum δ18O depletion and minimum recharge temperature. Neither latitude nor altitude effects could account for the sufficient isotopic depletion, instead, we found that the humid climate and permafrost meltwater also contributed to the isotope depletion. Simultaneously, the paleoclimatic environment such as freeze-thaw cycles of permafrost exerts a significant influence on the groundwater. The formation of permafrost hinders groundwater recharge, while its thawing dilutes the solute content of groundwater. Additionally, the recharge gaps also potentially result from arid climate, inadequate samples, and the effects of mixing water. The study substantiates the reliability of confined aquifers in permafrost thawing regions as robust paleoclimatic archives and emphasizes the utility of stable isotopes in combination with radiocarbon dating as ideal climate proxies.