Effect Of Age Research Articles

Dynamic performance of combined biochar from co-pyrolysis of pig manure with invasive weed: Effect of natural aging on Pb and As mobilization in polluted mining soil

Due to the natural biochar aging, the improvement of soil quality and immobilization of soil pollutants achieved by biochar may change; understanding the dynamic evolution of the in situ performance of biochar in these roles is essential to discuss the long-term sustainability of biochar remediation. Therefore, in this study, combined biochar from co-pyrolysis of pig manure and invasive Japanese knotweed – P1J1, as well as pure pig manure – PM – and pure Japanese knotweed – JK – derived biochar were applied to investigate their remediation performance in a high As- and Pb-polluted soil with prolonged incubation periods (up to 360 days). Biochar application, especially P1J1 and PM, initially promoted soil pH, dissolved organic carbon, and EC, but the improvements were not constant through time. The JK-treated soil exhibited the highest increase of soil organic matter (OM), followed by P1J1 and then PM, and OM did not change with aging. Biochar, especially P1J1, was a comprehensive nutrient source of Ca, K, Mg, and P to improve soil fertility. However, while soluble cationic Ca, K, and Mg increased with time, anionic P decreased over time, indicating that continuous P availability might not be guaranteed with the aging process. The total microorganism content declined with time; adding biochars slowed down this tendency, which was more remarkable at the later incubation stage. Biochar significantly impeded soil Pb mobility but mobilized soil As, especially in PM- and P1J1-treated soils. However, mobilized As gradually re-fixed in the long run; meanwhile, the excellent Pb immobilization achieved by biochars was slightly reduced with time. The findings of this study offer fresh insights into the alterations in metal(loid)s mobility over an extended duration, suggesting that the potential mobilization risk of As is reduced while Pb mobility slightly increases over time.

Estimating thoracic kyphosis without information on upper thoracic kyphosis: an observational study on 455 patients examined by EOS imaging

BackgroundPhysiological thoracic kyphosis (TK) allows sagittal balance of human body. Unlike lumbar lordosis (LL), TK has been relatively neglected in the literature. EOS is an imaging technique employing high-sensitivity xenon particles, featured by low-dose exposure combined with high accuracy compared to conventional radiography. The aim of this study was to investigate predictors of TK in patients with phyiological spine morphology using EOS imaging.MethodsEOS images of 455 patients without spinal anomalies were retrospectively assessed for TK (T1- T12), upper thoracic kyphosis (UTK, T1-T5), lower thoracic kyphosis (LTK, T5-T12), LL (L1-S1) and pelvic incidence (PI). The latter curves were measured by two researchers separately and the average of the two measurements was used for further analysis.Spearman non-parametric correlation was estimated for age, PI, LL, LTK, UTK and TK. Multiple robust linear regression analysis was employed to estimate TK, controlling for the effect of age, sex, LL and LTK.ResultsThe mean age of patients was 28.3 ± 19.2 years and 302 (66.4%) of them were females. The mean TK, UTK and LTK was 45.5° ± 9.3, 16 ± 7.4° and 29.7° ± 8.9, respectively. The mean UTK in people under 40 years of age was 17.0° ± 7.2, whereas for patients 40+ years old it was 13.6° ± 7.4. At univariable analysis TK positively correlated with UTK (p<0.001), LTK (p<0.001) an LL (p<0.001). At multivariable linear regression TK increased with LTK (RC = 0.67; 95%CI: 0.59; 0.75) or LL (RC = 0.12; 95%CI: 0.06; 0.18), whereas it decreased with age (RC = -0.06; 95%CI: -0.09;—0.02).ConclusionIf EOS technology is available, the above linear regression model could be used to estimate TK based upon information on age, sex, LL and LTK. Alternatively, TK could be estimated by adding to LTK 17.0° ± 7.4 for patients < 40 years of age, or 13.6° ± 7.4 in patients 40 + years old. The evidence from the present study may be used as reference for research purposes and clinical practice, including spine examination of particular occupational categories or athletes.

Educational level and gender are associated with emotional well-being in a cohort of Dutch dialysis patients

BackgroundPatients undergoing dialysis have an impaired health-related quality of life (HRQOL). There are conflicting data from small series on whether patient-related factors such as educational level have an impact on experienced HRQOL. The aim of this study was to investigate the association between educational level and HRQOL in dialysis patients.MethodsIn a single-center retrospective cross-sectional study HRQOL was measured using the Kidney Disease Quality of Life Short Form-36 (KDQOL-SF36) in prevalent chronic dialysis patients. Educational level was categorized into low, intermediate and high subgroups. Univariate and multivariate regression analyses were performed to assess the effects of age, gender, ethnicity, and dialysis vintage on the association between HRQOL and educational level.ResultsOne hundred twenty-nine chronic dialysis patients were included. Patients with an intermediate educational level had significantly higher odds of a higher emotional well-being than patients with a low educational level 4.37 (1.-89–10.13).A similar trend was found for a high educational level (OR 4.13 (1.04–16.42), p = 0.044) The odds for women compared to men were 2.83 (1.32–6.06) for better general health and 2.59 (1.15–5,84) for emotional well-being. There was no interaction between gender and educational level for both subdomains. Each year of increasing age significantly decreased physical functioning (OR 0.94 (0.91–0.97)).ConclusionsEducational level and sex were associated with emotional well-being, since patients with intermediate and high educational level and females had better emotional well-being in comparison to patients with low educational level and males. Physical functioning decreased with increasing age.

Prescription Opioid Dose Change Prior to Fatal Opioid-Detected Overdose.

The opioid overdose crisis continues within the U.S., and the role of prescribed opioids and prescribing patterns in overdose deaths remains an important area of research. This study investigated patterns of prescription opioids dispensed in the 12 months prior to opioid-detected overdose death in Connecticut between May 8th, 2016 and January 2nd, 2018, considering differences by demographic characteristics. The sample included decedents who had an opioid dispensed within 30 days preceding death. Using multilevel modeling, we estimated the slope of change in mean morphine equivalent (MME) daily dose over 12 months prior to death, considering linear and quadratic effects of time. We estimated the main effects of age, sex, race, and ethnicity and their interactions with time on MME. A sensitivity analysis examined how excluding decedents who did not receive long-term (≥90 days) opioid therapy affected mean MME slopes. Secondary analysis explored differences by toxicology results. Among 1,580 opioid-detected deaths, 179 decedents had prescribed opioids dispensed within 30 days preceding death. Decedents' mean age was 47.3 years (±11.5), 65.5% were male, 81% White non-Hispanic, 9.5% Black non-Hispanic, and 9.5% Hispanic. In the time-only model, linear (β=6.25, p<0.01) and quadratic (β=0.49, p=0.02) effects of time were positive, indicating exponentially increasing dose prior to death. Linear change in MME was significantly attenuated in men compared to women (β=-4.87, p=0.03); however, men were more likely to have non-prescription opioids in their toxicology results (p=0.02). Sensitivity analysis results supported primary findings. Rapid dose increases in dispensed opioids may be associated with opioid-detected overdose deaths, especially among women.

Application of black tea waste as eco-friendly deflocculant and rheology stabilizer for water-based mud

Maintaining and regulating the rheological properties of the drilling mud at the desired level is essential for successful drilling operations. Bentonite is the key additive used in most water-based drilling mud for enhanced rheological properties. However, the flocculation tendency of bentonite particles poses a significant challenge for the industry due to the undesirable and unpredictable changes in rheological properties of the fluid with downhole increasing temperature. This study aims to develop a low-cost and eco-friendly deflocculant from black tea waste (BTW) that can prevent the aggregation and flocculation of the bentonite and stabilize the rheology of bentonite-polymer muds. Rheological properties were evaluated with different concentrations (0.25%, 0.5%, 0.75%, and 1%) of BTW at 95 °F and 140 °F. The Bingham Plastic (BP) and Power Law (PL) models were studied to characterize the flow behavior and identify the best-fit model through statistical analysis. Along with rheological properties, thinning efficiency, mud stability, thermal aging effect, thixotropic behavior, and shear thinning behavior were investigated through different shear-temperature-time dependent tests. In addition, the lubricating properties and filtration loss characteristics were assessed at ambient conditions. Finally, the findings were compared with the industrially used deflocculant, lignosulphonate (LS). The results revealed that BTW can effectively prevent bentonite flocculation and stabilize the mud rheology even at a very low concentration of 0.25%. Significant improvements were observed in the lubricating and filtration characteristics. With the addition of 1% BTW, the filtrate loss, mud cake thickness, and friction coefficient were reduced by 22.2%, 50%, and 13.29%, respectively. The multifunctional activities of black tea waste (BTW) are attributed to its polyphenolic compounds, the presence of which was confirmed through UV–visible spectroscopy testing. The TG analysis confirmed that BTW remains thermally stable up to 200 °C. Considering the synergistic performance compared with lignosulphonate, availability, and environmental and economic acceptance, BTW may be effectively utilized as a multifunctional deflocculant and rheology stabilizer for water-based bentonite-polymer muds.

The curvilinear relationships between perceived development human resource practices and both affective commitment and work stress: the moderating effects of age

PurposeThis paper aims to reveal the curvilinear relationships between perceived development human resource practices (DHRPs) and both affective commitment and work stress, and the moderating effects of age on the curvilinear relationships.Design/methodology/approachHypotheses were developed from an employee-oriented contingent view based on the person-job fit theory and lifespan development theories. Methods suggested by Haans et al. (2016) and Dawson (2014) to test curvilinear relationships and related moderations, and a two-wave survey data from 742 Chinese employees were used.FindingsThe results showed that perceived DHRPs related to affective commitment in an inverted U shape and work stress in a U shape. However, age moderated the nature of the relationships such that both the curvilinear relationships only existed under low age while under high age perceived DHRPs related to affective commitment positively and work stress negatively.Originality/valueThis study advances the prevailing linear (positive or negative) thinking on the DHRPs–outcomes relationships by showing that perceived DHRPs relate to both affective commitment and work stress nonlinearly. Moreover, different from existing findings that age moderates the strength of the linear DHRPs–outcomes relationships, the results indicate that age moderates the nature of the relationships between perceived DHRPs and affective commitment and work stress. This implies a refined age-differential approach to use DHRPs to sustain a committed and healthy workforce in the context of workforce aging.

Standardization of Three Familiar Sound Recognition Tests in Hearing and Deaf Adult Populations.

Recognition of familiar noises is crucial for understanding and reacting appropriately to our auditory environment. Its improvement is one of the benefits expected after cochlear implantation. The aim of this study was to standardize three environmental sounds noise recognition tests and to illustrate their application to a population of deaf adults with cochlear implants. Norms were established on a sample of 126 normal-hearing adults divided into 6 age groups. Three familiar sound recognition tests were used: 1) the Blue Mouse "First Familiar Sounds" (BM), 2) the UCL-IRSA test (TI), and 3) the Bernadette Piérart Familiar Sounds Test (TBF). These tests were also administered to 61 implanted deaf ears. We observed a significant effect of age on the accuracy scores of the TI and TBF tests for the hearing group and on the time scores of the TI and BM tests. Overall, the performance of the deaf participants was poorer and more variable than that of the hearing participants. We have three tests that can be used in practice to measure the performance of deaf people (with cochlear implants) at different stages of their pre- and post-implant rehabilitation.

Ageing effect: the impact of chair-CEO age dissimilarity on investment efficiency

ABSTRACT According to different research paradigms, the impact of chair-CEO age dissimilarity on corporate decision-making may have a bright side or a dark side. This paper discusses the effect of chair-CEO age dissimilarity on investment efficiency in China. Using the sample of public firms from 2005 to 2019, we find an ‘ageing effect’ that a normative age gap between the chair and CEO improves firms’ investment efficiency by mitigating under-investment. Our finding deepens the understanding of the antecedent and the mechanism of investment efficiency from the micro-perspective of executives’ age differences.

Association between time of assessment within a school year and physical fitness of primary school children

The dissociation of effects of age, time of assessment and cohort is a well-known challenge in developmental science. We examined effects of time of assessment in the school year on children’s physical fitness using data from 75,362 German third-graders from seven cohorts. Children were tested once either in the first or second school term of third grade. Tests examined cardiorespiratory endurance (6-min run), coordination (star-run), speed (20-m sprint), lower (standing long jump) and upper (ball-push test) limbs muscle power, and flexibility (stand-and-reach test). We estimated the effect of time of assessment using a regression discontinuity design specified in a linear mixed model with random factors child and school and adjusted for age, sex, and cohort effects. Coordination, speed, and upper limbs muscle power were better in second compared to first school term, with boys exhibiting a larger increase of upper limbs muscle power than girls. There was no evidence for changes in cardiorespiratory endurance, lower limbs muscle power, and flexibility between assessments. Previously reported age and sex effects as well as secular fitness trends were replicated. There is thus evidence for improvement of some physical fitness components beyond age and cohort effects that presumably reflects the benefit of physical activity in physical education and other settings. Effects of assessment time should be taken into consideration in performance-based grading or norm-based selection of children.

Taste Preferences in Broilers: Effect of Age, Delivery Matrix, and Number of Chickens per Pen on Selection and Consumption Behaviour

Due to substantial differences between studies, the understanding of avian taste perception remains incomplete. Also, studies on chicken taste preferences have mainly focused on measuring consumption differences, neglecting consumption behaviour patterns. This study investigated how age, the compound delivery matrix, and the number of birds per pen affect broiler chicken preferences and consumption behaviour, and established their preference values for four taste compounds. Ninety-six one-day-old male broiler chickens (Ross 308) were divided into two age groups (initial: days 7–23; final: days 26–42), with two compound delivery matrices (water or ground wheat) and two numbers of birds (one or two chickens per pen), following a 2 × 2 × 2 factorial design. Four taste compounds (sucrose, monosodium glutamate (MSG), L-lysine, and calcium carbonate) were tested at different concentrations. Preferences were assessed at 2, 4, and 8 h post-test, along with recording various behavioural parameters. Initial-stage birds showed higher (p &lt; 0.001) preference values, time of approach (TA), number of bouts (NB), duration of bouts (DB), and number of pecks (NP) than final-stage birds. Birds exposed to a water matrix also exhibited higher (p &lt; 0.001) preference and NB, while those exposed to a ground wheat matrix showed a higher (p &lt; 0.001) NP. Pens with a pair of birds had a higher (p &lt; 0.003) 2 h preference, TA, NB, DB, and NP, than pens with a single chicken. Chickens showed significant preference values for 100 mM sucrose at 2 h (p = 0.025), 150 mM MSG at 4 h (p = 0.026) and 8 h (p = 0.013), and 300 mM MSG at 2 h (p = 0.013). We concluded that all the variables evaluated influence broilers’ taste preferences and consumption behaviour during selection tests. Future studies should prioritize including chickens in the initial stage of the production cycle, testing them in pairs or groups, and delivering compounds via a liquid matrix.

Physiological Age of Potato Seed Tubers of Contrasting Cultivars Hardly Affects Crop Performance in a Temperate Climate

AbstractThe physiological age of potato seed tubers influences the subsequent field performance of the crop, conditioning its growth and development. This study investigates the effects of the physiological age of seed tubers on the field performance of four contrasting, currently widely grown cultivars (Agria, Festien, Innovator, Lady Claire) across three sites in the Netherlands over 3 years (Cycles 1—3). Seed tubers were produced annually at a single site under uniform conditions, with variations in physiological age induced by applying different storage temperatures (4, 7, 10, and/or 17 °C). Our previous study revealed varying effects of storage temperature on sprouting behaviour among cultivars, suggesting different rates of ageing. After completing the storage season, in the current study these seed tubers were planted in the field and subsequent crop performance was thoroughly phenotyped. Cultivar-specific effects of storage temperature were evident during early growth stages and when seed tubers were stored at 17 °C in Cycle 3. However, within the storage temperature range of 4 to 10 °C, the influence of storage temperatures was small or inconsistent. Overall, effects on canopy cover, stem and tuber number, yield and quality, and tuber yield explanatory variables were limited. The outcomes suggest that while very high storage temperatures should be avoided in regions with long crop cycles, stringent cold storage regimes are unnecessary to achieve optimal growth vigour in potato seed tubers of the studied cultivars in a temperate climate.

Effects of multi-axial compression and double-step aging on the microstructure and mechanical properties of Al alloy 7075

This study investigates the combined effect of severe plastic deformation via multi-axial compression (MAC) and subsequent double-step aging on the microstructure and mechanical properties of annealed 7075 Al alloy. Three distinct processes were employed: (1) double-step aging on the annealed sample, (2) double-step aging on the six-MAC pass processed sample, and (3) double-step aging without solutionization on the six-MAC pass sample. Process (2) yielded the most significant improvements in mechanical properties. Compared to the annealed sample, the six-MAC pass, double-step aged sample exhibited an average ultimate tensile strength increase of 134% and an average Vickers micro-hardness (HV) increase of 209%. This superior performance is likely attributable to the synergistic effect of grain refinement induced by MAC and precipitate hardening achieved through double-step aging. A comprehensive analysis of microstructure evolution, mechanical properties, fractography, and the relationship between them was conducted for all three processes. This in-depth examination provided valuable insights into the mechanisms governing the observed property enhancements, particularly in process (2). Additionally, a variety of characterization techniques were employed to comprehensively evaluate the material's mechanical and microstructural characteristics.

Cross-sectional study on the epidemiological investigation ability of professional staff from Centers for Disease Control and Prevention in Guizhou Province.

This study aims to evaluate the qualifications and identify skill enhancement areas for epidemiological investigators in Centers for Disease Control and Prevention (CDCs) in Guizhou's, informing future training and policy initiatives to strengthen public health responses. A cross-sectional survey was conducted in August 2022, and an online, self-designed questionnaire on the Epidemiological Dynamic Data Collection platform was administered to evaluate the professional staff in CDCs. The responses were scored and presented using descriptive statistical methods, and the factors influencing the total score were analyzed by one-way ANOVA and linear regression. A total of 1321 questionnaires were collected, yielding an average score of 14.86±3.49 and a qualification rate of 29.9%. The scoring rate of ability of individual protection and coordination in epidemic control was high (87.25%). Meanwhile, improvements in further training were needed in areas such as data analysis ability (23.67%), knowledge of site disinfection (40.40%), and epidemiological investigation skills (42.50%). No significant difference was observed between the scores of city and county CDCs, (t = 1.071, p =0.284). The effects of gender and age could be disregarded, and the experience in epidemiological work and training (including investigation on COVID-19 cases and contacts), educational background, and professional title partially explained the survey outcome (R Square of the linear regression model was 0.351). The survey indicated the need for additional well-trained epidemiologic investigators in Guizhou. Specified training was effective in improving epidemiologic investigation, and enhancement in data analysis ability and knowledge of field disinfection are recommended in professional staff cultivation.

Mechanism of DSA effect correlating to the macroscopic PLC banding in high-Mn austenitic steel

Mechanism of dynamic strain aging (DSA) effect in high-Mn austenitic steel, and its correlation with the Portevin-Le Chatelier (PLC) banding, was elucidated using the in-situ synchrotron XRD measurement and digital image correlation (DIC) method during tensile test. The average dislocation velocity beyond the PLC band ranged from 10−2 to 10−1 nm/s, while reached to the order of 10° nm/s within the PLC band. In comparison, carbon diffusivity was significantly lower, allowing carbon atoms to diffuse only from 10−7 to10−9 nm in one second. The findings indicate that dislocations beyond the advancing PLC band were pinned by nearby carbon atoms, while dislocations within the PLC band became de-pinned from the carbons. Such localized pinning and de-pinning of dislocations occurred sequentially during deformation, appearing as the propagation of PLC bands in macroscopic scale.

Systematic review and meta-analysis:relative age in attention-deficit/ hyperactivity disorder and autism spectrum disorder.

Youngest students in their class, with birthdates just before the school entry cut-off date, are overrepresented among children receiving an Attention-Deficit/Hyperactivity Disorder (ADHD) diagnosis or medication for this. This is known as the relative age effect. This systematic review and meta-analysis summarises the evidence on the influence of relative age on ADHD symptoms, diagnosis and medication prescribing. As no review to date has investigated the association with autism spectrum disorder (ASD) diagnosis, this is also examined. Following prospective registration with PROSPERO, we conducted a systematic review according to the PRISMA guidelines. We searched seven databases: Medline, Embase, PsycInfo, Web of Science Core Collection, ERIC, Psychology and Behavioural Sciences Collection, and Cochrane Library. Additional references were identified from manual search of retrieved reviews. We performed a meta-analysis of quantitative data. Thirty-two studies were included, thirty-one investigated ADHD and two ASD. Younger relative age was associated with ADHD diagnosis and medication, with relative risks of 1.38 (1.36-1.52 95% CI) and 1.28 (1.21-1.36 95% CI) respectively. However, risk estimates exhibited high heterogeneity. A relative age effect was observed for teacher ratings of ADHD symptoms but not for parent ratings. With regard to ASD, the youngest children in their school year were more likely to be diagnosed with ASD. This review confirms a relative age effect for ADHD diagnosis and prescribed ADHD medication and suggests that differences in teacher and parent ratings might contribute to this. Further research is needed on the possible association with ASD.

The Intersection of a Child's Demographics and Household Socioeconomic Status in the Multimorbidity of Malaria, Anaemia, and Malnutrition among Children Aged 6-59 Months in Nigeria.

Multimorbidity of malaria, anemia, and malnutrition (MAMM) is a condition in which an individual has two or more of these health conditions, and is becoming an emergent public health concern in sub-Saharan African countries. The independent associations of a child's demographic variables and household socioeconomic (HSE) disparities with a child's health outcomes have been established in the literature. However, the effects of the intersection of these factors on MAMM, while accounting for other covariates, have not been studied. Therefore, this study aimed to determine how children's sex, age, and household socioeconomic status interact to explain the variations in MAMM among children aged 6-59 months in Nigeria. Data from the 2018 Nigeria Demographic and Health Survey and the 2018 National Human Development Report (NHDR) were used. This study included weighted samples of 10,184 children aged 6-59 months in Nigeria. A three-level multilevel mixed effect ordinal logistic regression model was used, such that individual characteristics at level 1 were nested in communities at level 2 and nested in states at level 3. Subsequently, predictive probability charts and average adjusted probability tables were used to interpret the intersectional effects. Five models were created in this scenario. Model 1 is the interaction between the child's sex and household wealth status; model 2 is the interaction between the child's sex and age; model 3 is the interaction between the child's age and household wealth status; model 4 has the three two-way interactions of the child's sex, age, and household wealth status; and model 5 includes model 4 and the three-way interactions between a child's sex, age, and household wealth quintiles; while accounting for other covariates in each of the models. The prevalence of children with a 'none of the three diseases' outcome was 17.3% (1767/10,184), while 34.4% (3499/10,184) had 'only one of the diseases', and 48.3% (4918/10,184) had 'two or more' MAMMs. However, in the multivariate analyses, model 3 was the best fit compared with other models, so the two-way interaction effects of a child's age and household wealth status are significant predictors in the model. Children aged 36-47 months living in the poorest households had a probability of 0.11, 0.18, and 0.32 of existing with MAMM above the probability of children of the same age who live in the middle class, more prosperous, and richest households, respectively, while all other covariates were held constant. Thus, the variation in the prevalence of MAMM in children of different ages differs depending on the household wealth quintile. In other words, in older children, the variations in MAMM become more evident between the richer and the poorer household quintiles. Therefore, it is recommended that policies that are geared toward economic redistribution will help bridge the disparities observed in the prevalence of multiple diseases among children aged 6-59 months in Nigeria.

Investigation on work hardening rate of Al-Zn-Mg-Cu alloy under solid solution process and thermomechanical coupled multi-step fast aging process

In this paper, the work hardening rate of Al-Zn-Mg-Cu alloy in the conditions of solid solution and thermo-mechanical coupled fast aging were investigated separately, and the main research content and results are as follows. Under the solid solution processes at different temperatures, the uniaxial tensile test curves of work hardening rate are relatively dispersed at a lower strain rate, and the work hardening rate increases with the increase of solution temperature. Then, as the strain rate increasing, the work hardening rate curves at each solution temperature gradually converge, until all curves intersect at a common intersection point. The above mechanism is attributed to the comprehensive effect of precipitates, solid solutions, and dynamic strain aging in the matrix. For the thermo-mechanical coupled aging, the work hardening rate has a great different with that of solid solution process. Consequently, the influence of pre-deformation on the work hardening rate were investigated, which concludes the curve shape type and the softening coefficient. The introduction of dislocation have some significant influences on the work hardening rate. Firstly, it makes the shape of work hardening rate curves change from shape 1 to shape 2. On the other hand, as the pre-deformation increasing, the variation law of softening coefficient shows an abnormal trend that is different from the ordinary law, which is due to the coordinated effect between dislocation density and dislocation induced precipitation. Furthermore, in order to reveal the internal mechanism in depth, the microstructure are observed by TEM (Transmission electron microscope). Finally, a targeted set of analytical models for work hardening rate were established, especially the mathematical explanation of the multicollinearity phenomenon of work hardening rate curves in the solid solution condition.

Assessment of secular trends of three major gynecologic cancers burden and attributable risk factors from 1990 to 2019: an age period cohort analysis

BackgroundThis study aims to assess the long-term trends in the burden of three major gynecologic cancers(GCs) stratified by social-demographic status across the world from 1990 to 2019. To assess the trends of risk factor attributed mortality, and to examine the specific effects of age, period, cohort behind them in different regions.MethodsWe extracted data on the mortality, disability-adjusted life years(DALYs), and age-standardized rates(ASRs) of cervical cancer(CC), uterine cancer(UC), and ovarian cancer(OC) related to risks from 1990 to 2019, as GCs burden measures. Age-period-cohort analysis was used to analyze trends in attributable mortality rates.ResultsThe number of deaths and DALYs for CC, UC and OC increased since 1990 worldwide, while the ASDRs decreased. Regionally, the ASDR of CC was the highest in low SDI region at 15.05(11.92, 18.46) per 100,000 in 2019, while the ASDRs of UC and OC were highest in high SDI region at 2.52(2.32,2.64), and 5.67(5.16,6.09). The risk of CC death caused by unsafe sex increased with age and then gradually stabilized, with regional differences. The period effect of CC death attributed to smoking showed a downward trend. The cohort effect of UC death attributed to high BMI decreased in each region, especially in the early period in middle, low-middle and low SDI areas.ConclusionsGlobal secular trends of attributed mortality for the three GCs and their age, period, and cohort effects may reflect the diagnosis and treatment progress, rapid socioeconomic transitions, concomitant changes in lifestyle and behavioral patterns in different developing regions. Prevention and controllable measures should be carried out according to the epidemic status in different countries, raising awareness of risk factors to reduce future burden.

Resilience in the first year of surviving a stroke in Nigeria

Objectives There is a knowledge gap on resilience and its impact on mental health of Africans who survive a stroke. We describe the trajectory of psychological resilience and its association with depression and quality of life (QoL) across the first poststroke year in Nigeria. Method Prospective observational study of 150 survivors of a first ever stroke. Resilience was ascertained at 3 time-points prospectively over 12 months using the 25-items Resilience Scale (RS). Depression and QoL were also assessed at baseline and follow-up, respectively using the centre for epidemiologic studies depression scale (CES-D 10) and health related quality of life in stroke patients (HRQOLISP-26). Associations were investigated using regression models and presented as adjusted odds ratios (OR) and Wald test coefficients within 95% confidence intervals (CI). Results Resilience improved across time points of measurement (p < 0.001). In multivariate logistic regression analyses adjusted for the effect of age, education, alcohol use, and hypertension, higher resilience was associated with male sex (OR = 5.3, 95% CI= 1.7, 17.2), younger age (OR = 4.8, 95% CI = 1.5,15.7), and baseline hypertension (OR= 0.2, 95% CI ≤ 0.1,0.8). In similarly adjusted mixed effect linear regression analyses, higher resilience was associated with improvement in depression (months 12= −4.2, 95% CI= −5.6, −2.8) and quality of life (months twelve = 5.2, 95% CI = 2.2, 8.2) overtime. Conclusion Resilience, which was associated with better mental health and wellbeing of stroke survivors, was less likely with hypertension. Results suggest an important role for control of vascular risk factors as part of resilience interventions to promote poststroke recovery.

Oral health status, oral health behavior, and frailty: A cross-sectional study

BackgroundThere is an association between oral health and frailty, implying that tooth loss and periodontal disease increase the risk of frailty. To examine the association between oral health status and behaviors and frailty in individuals aged ≥ 75 years. MethodsA total of 7,927 participants underwent oral health examinations at the ages of 75, 77, and 80 years. The questionnaire for medical checkup of old-old (QMCOO) was used to assess frailty. Modified Poisson regression analysis was performed, with frailty as the dependent variable and family dentist, regular dental checkups, number of teeth, periodontal status, and swallowing function as independent variables. Modified Poisson regression analyses were conducted using the presence or absence of nine QMCOO domains (excluding smoking) as dependent variables. ResultsParticipants with a family dentist, those who underwent regular dental checkups, and those with a greater number of teeth had significantly lower relative risks (RRs) for frailty, with RRs of 0.72 [95 % confidence interval (CI): 0.59–0.89], 0.70 (95 % CI: 0.63–0.79), and 0.97 (95 % CI: 0.96–0.98), respectively. By contrast, individuals with periodontal pockets ≥ 6 mm and those with reduced swallowing function had significantly higher RRs for frailty [1.17 (95 % CI: 1.01–1.36) and 1.94 (95 % CI: 1.57–2.40), respectively]. Oral health status and behavior were also associated with QMCOO domains. ConclusionOlder individuals with good oral health had a lower likelihood of frailty. Regular oral care provided by a family dentist can reduce some of the negative effects of aging.