It is impossible to overlook the curricular advancements occurring all across the world. The evaluation methods should be revised in addition to the course objectives, programmes, and competences. If courses are evaluated the same way they have been in the past, we will not progress in education. We are on the verge of an educational revolution that will fundamentally alter how we educate and assess students. E-portfolios have now become recognized and valued by everyone in medical education and the workplace, including policymakers. For programmatic assessments, E-portfolios are the best supporting document one can use as a qualitative assessment. It can be used in many ways including career planning, assessment, and for structured feedback. E-Portfolio provides a secured database and then there are numerous ways to use this knowledge. It allows a learner to gather and exhibit proof of their accomplishments and proficiency in order to support the modern techniques of academic assessment. In this article, we suggest 12 tips for putting a portfolio programme for undergraduate students into practice. The suggestions are based on an extensive evaluation of the literature, and the authors' personal experiences helped lay the groundwork for the recommendations.