Eczematous Sensitization Research Articles

Failure to prevent experimental eczematous sensitization; Observations on the “spontaneous” flare-up phenomenon

1. 1. An attempt was made in human subjects to specifically lessen their susceptibility to eczematous contact-type sensitization with dinitrochlorbenzene. This was done by applying to their skin subsensitizing doses of this agent for several weeks prior to exposure to a quantity of this agent, which is known frequently to incite sensitization. 2. 2. No diminution was noted in the capacity of such subjects to become sensitized to dinitrochlorbenzene as compared with a not pretreated control group. 3. 3. Seventy of 124 subjects exposed to the potentially sensitizing doses of dinitrochlorbenzene developed a “spontaneous” flare-up, but several weeks later 20 of these could no longer be shown to be hypersensitive to this compound. 4. 4. It appears possible that sensitization followed by early “spontaneous” desensitization may not be an uncommon immunologic phenomenon in allergic eczematous sensitization.

The effect of the development of an eczematous sensitization to a drug on the pharmacologic properties of that drug

1. 1. The pharmacological properties of an adrenergic blocking drug, SY-28, were studied in the skin. 2. 2. It was found that the drug SY-28 when introduced into the skin by ion transfer was a powerful eczematous sensitizer. 3. 3. It was found that these properties were unchanged by the development of an eczematous sensitization to the drug, even when the pharmacological reaction was tested at the site of and at the height of the sensitization reaction. 4. 4. There was a suggestion that the ability of the drug SY-28 to block epinephrine was actually enhanced by the genesis of the sensitization. 5. 5. This is the first investigation which quantitatively studied the effect of the development of an eczematous sensitization on the pharmacological properties of the antigen. 6. 6. Theories are advanced to explain the possible effects of the sensitization on the blocking properties of the drug.

Studies on the Eczematous Sensitization : II. The Effect of the Engendering of an Eczematous Sensitization on the Threshold of Reaction to Primary Irritants

Studies on the Eczematous Sensitization : II. The Effect of the Engendering of an Eczematous Sensitization on the Threshold of Reaction to Primary Irritants

ECZEMATOUS SENSITIZATION

WHEN the living organism comes into either external or internal contact with a foreign substance a variety of alterations may ensue. One of these is a subtle change in the body's economy, which is not immediately manifest, so that on again meeting the substance the organism presents an altered reactivity to it. This altered reactivity is what is termed the allergic reaction, and when this state of altered reactivity has developed, the organism is said to be sensitized. There are, however, different possible varieties of sensitizations of which at least three appear to be distinct immunologic entities. These are: (1) the anaphylactic (of which I regard the atopic as a part), (2) the tuberculin or bacterial and (3) the eczematous variety. It is with this last variety that this paper deals. NATURE OF THE SUBSTANCES WHICH YIELD ECZEMATOUS SENSITIZATIONS In considering the nature of the substances which elicit eczematous sensitizations

Studies on the Eczematous Sensitization: I. The Route by Which the Sensitization Generalizes

Studies on the Eczematous Sensitization: I. The Route by Which the Sensitization Generalizes

A case of contact dermatitis of the eczematous type resulting from sensitization to natural animal hair

1. 1. A case is reported of a woman who developed an eczematous sensitization to the natural hair of several animals, namely, coati-mundi, raccoon, and skunk. 2. 2. The eczematous allergen of the hair seems to be common to the members of the Procyonidae and possibly other families. 3. 3. The eczematous allergen was found not to be acetone or ether soluble.

Studies on Eczematous Sensitizations: The Specificity of the Sensitization from the Point of View of Chemical Configuration

Studies on Eczematous Sensitizations: The Specificity of the Sensitization from the Point of View of Chemical Configuration

Studies in Eczematous Sensitizations: I. A Comparison Between the Sensitizing Capacities of Two Allergens and Between Two Different Strengths of the Same Allergen and the Effect of Repeating the Sensitizing Dose

Studies in Eczematous Sensitizations: I. A Comparison Between the Sensitizing Capacities of Two Allergens and Between Two Different Strengths of the Same Allergen and the Effect of Repeating the Sensitizing Dose

Individual Differences in Susceptibility to Eczematous Sensitization with Simple Chemical Substances

Individual Differences in Susceptibility to Eczematous Sensitization with Simple Chemical Substances

Sensitization to simple chemicals. Relationship between chemical structures and properties and the sensitizing capacities in the production of eczematous sensitivity in man: Sulzberger, M. B., and Baer, R. A.: J. Invest. Dermat. 1: 45, 1938

Sensitization to simple chemicals. Relationship between chemical structures and properties and the sensitizing capacities in the production of eczematous sensitivity in man: Sulzberger, M. B., and Baer, R. A.: J. Invest. Dermat. 1: 45, 1938

Sensitization to Simple Chemicals: III. Relationship between Chemical Structure and Properties, and Sensitizing Capacities in the Production of Eczematous Sensitivity in Man

Sensitization to Simple Chemicals: III. Relationship between Chemical Structure and Properties, and Sensitizing Capacities in the Production of Eczematous Sensitivity in Man

Acquired specific hypersensitivity to simple chemicals: I. Eczematous sensitivity to clothing and to cosmetics; With special reference to dyes

Various types of eczematous contact dermatitis due to allergy to dyes are discussed. The clinical course and appearance of dress dermatitis in the female are considered in detail. Twenty-five cases are reported, in which the dermatitis was proved to be due to dyed dress materials. The results of patch test studies of these patients are reported. The polyvalence of sensitivity found in many of these cases, and the many difficulties encountered in the prophylaxis of dress dermatitis are discussed. Brief mention is made of the possible rôles of perspiration, friction, occupation, etc., in the production of the sensitivity and in the precipitation of the attacks. The clinical course and the appearance of clothing dermatitis in the male are also discussed, and two pertinent cases are reported. Other types of dye dermatitis are mentioned including dermatitis of the feet due to shoe leathers, which is discussed in the light of studies made on 5 patients. Among the causes of dermatitis produced by cosmetics, dyes play a significant rôle. In illustration of this point reference is made to the authors' studies of 14 cases of lipstick sensitivity. Attention is directed to the ubiquitous presence of dyes and dyed substances and of the possible importance of dyes or dye-conjugates in forms of allergy other than contact dermatitis.