Acquired specific hypersensitivity to simple chemicals: I. Eczematous sensitivity to clothing and to cosmetics; With special reference to dyes

Abstract

Various types of eczematous contact dermatitis due to allergy to dyes are discussed. The clinical course and appearance of dress dermatitis in the female are considered in detail. Twenty-five cases are reported, in which the dermatitis was proved to be due to dyed dress materials. The results of patch test studies of these patients are reported. The polyvalence of sensitivity found in many of these cases, and the many difficulties encountered in the prophylaxis of dress dermatitis are discussed. Brief mention is made of the possible rôles of perspiration, friction, occupation, etc., in the production of the sensitivity and in the precipitation of the attacks. The clinical course and the appearance of clothing dermatitis in the male are also discussed, and two pertinent cases are reported. Other types of dye dermatitis are mentioned including dermatitis of the feet due to shoe leathers, which is discussed in the light of studies made on 5 patients. Among the causes of dermatitis produced by cosmetics, dyes play a significant rôle. In illustration of this point reference is made to the authors' studies of 14 cases of lipstick sensitivity. Attention is directed to the ubiquitous presence of dyes and dyed substances and of the possible importance of dyes or dye-conjugates in forms of allergy other than contact dermatitis.