Global scale changes in land use affect biodiversity, global climate, and ecosystem services. Integrating a local and regional ecosystem service approach into plans and policies levels is essential for sustainable land management. In this study, land use/land cover differences in Adana-Karaisali district of Turkey were investigated using Normalized Difference Vegetation Index (NDVI). Landsat satellite images of the area from 2000 and 2016 were analyzed using ISODATA method and 16 land use were identified based on the third level of the CORINE classification framework. The results showed that the biggest changes occurred in agricultural areas, 2.57% decrease in non-irrigated arable land while a 7.14% increase was observed in permanently irrigated lands. In spite of the decrease in the number of inhabitants in the area, continuous urban fabric increased at the rate of 0.07% and 7.62% increase was observed in forest lands. The positive or negative effects of the identified changes on ecosystem services based on the Common International Classification of Ecosystem Services (CICES) framework were evaluated. In the case of Karaisalı, in spite of the decrease in water bodies and natural landscapes, it has been observed that increases in agricultural areas, forests, and artificial surfaces positively have affected ecosystem services valuation in the district.