This document deals with the Peruvian economy, Peruvian mining and Puno region, its potential, its social problems, the urgent issues to solve, among them: malnutrition, infantile anemia, employment generation, among others. The regional economy is described in terms of GDP, employment and per capita income indicators. Also includes some recommendations to be implemented. After the deep economic crisis (late 1989); the Peruvian economy presents a recovery and during the last two decades, we lived an amazing economic recovery in which mining plays a very important role, putting value on other activities. What made this possible? A new legal framework that promotes and guarantees private investment in addition to the right management of fiscal and monetary policies. However, mining in the Puno region has not been similar to the national advancement, because, Puno is not a mining region like the other regions of Peru, although it may seem otherwise, due to the news of informal mining and the illegal mining that is practiced in the region. Mining in Puno in terms of production, mining reserves, problems and future perspectives on what should be done. The great challenge is to incorporate informal miners to be formal so that they can receive benefits from government services and can pay their taxes. In recent weeks, the discovery of a lithium deposit in Macusani, Carabaya Province, that has been reported. The development of this mining project would change the regional economy and the country, even more if it is given added value.