The article emphasizes the importance of increasing and effective implementation of the investment and innovation potential, which allows to form the necessary prerequisites for fully ensuring the country's economic security. The importance of state support for the processes of building up and effective realization of investment-innovation potential has been proven, where the state is required to create an attractive regulatory environment with a focus on stimulating the establishment of investment-innovation activity, its rapid and stable growth. Obstacles that discourage investment and innovation activity in the economic system of Ukraine are identified, and their overcoming should become the main task of state regulatory bodies. Based on the analysis of the latest research and publications, it was concluded that the existing system of state regulation of investment and innovation activity is aimed at solving current tasks, and the strategic issues of its development from the standpoint of ensuring economic security are not properly resolved. Emphasis is placed on increasing the significance of this direction of state policy in the system of economic security of Ukraine, when it is necessary to resist external military and hybrid aggression. The priority means of the state policy of increasing and effectively realizing the investment and innovation potential in the system of economic security of Ukraine are summarized, the implementation of which should begin as soon as possible, and at the same time, their list should be reviewed in view of the peculiarities of the regional economy, types of economic activity, etc. It was emphasized that solving the problem of the low level of investment and innovation potential of Ukraine requires updating the national economic development strategy. Keywords: investment and innovation potential, economic security, state policy, investment and innovation activity, expansion, effective implementation.