Based on the regional industry association table published by the Bank of Korea (as of 2015, July 2022), this study analyzed the economic ripple effect of R&D investment in the southeastern region of Korea (Busan, Ulsan, and Gyeongnam) on each region of the country and the economic ripple effect on individual industries in the southeast region. As a result of analyzing the economic effect of R&D investment in the southeast region on each region, it was found that the effect was the highest in the southeast region, which is its own region, in all sectors such as the production inducement coefficient, the value-added inducement coefficient, and the employment inducement coefficient, followed by the high economic ripple effect on the metropolitan area. In addition, as a result of analyzing the effect of R&D investment in the southeast region on each industry in the southeast region, it was found that the production inducement effect had a large ripple effect on the manufacturing sector, and the job creation effect had a large economic ripple effect on the service industry.