Economic Review Research Articles

Lenvatinib plus pembrolizumab for untreated advanced renal cell carcinoma: a systematic review and cost-effectiveness analysis.

Renal cell carcinoma is the most common type of kidney cancer, comprising approximately 85% of all renal malignancies. Patients with advanced renal cell carcinoma are the focus of this National Institute for Health and Care Excellence multiple technology appraisal. A patient's risk of disease progression depends on a number of prognostic risk factors; patients are categorised as having intermediate/poor risk or favourable risk of disease progression. The objectives of this multiple technology appraisal were to appraise the clinical effectiveness and cost-effectiveness of lenvatinib plus pembrolizumab versus relevant comparators listed in the final scope issued by the National Institute for Health and Care Excellence: sunitinib, pazopanib, tivozanib, cabozantinib and nivolumab plus ipilimumab. The assessment group carried out clinical and economic systematic reviews and assessed the clinical and cost-effectiveness evidence submitted by Eisai, Hatfield, Hertfordshire, UK (the manufacturer of lenvatinib) and Merck Sharp & Dohme, Whitehouse Station, NJ, USA (the manufacturer of pembrolizumab). The assessment group carried out fixed-effects network meta-analyses using a Bayesian framework to generate evidence for clinical effectiveness. As convergence issues occurred due to sparse data, random-effects network meta-analysis results were unusable. The assessment group did not develop a de novo economic model, but instead modified the partitioned survival model provided by Merck Sharp & Dohme. The assessment group clinical systematic review identified one relevant randomised controlled trial (CLEAR trial). The CLEAR trial is a good-quality, phase III, multicentre, open-label trial that provided evidence for the efficacy and safety of lenvatinib plus pembrolizumab compared with sunitinib. The assessment group progression-free survival network meta-analysis results for all three risk groups should not be used to infer any statistically significant difference (or lack of statistically significant difference) for any of the treatment comparisons owing to within-trial proportional hazards violations or uncertainty regarding the validity of the proportional hazards assumption. The assessment group overall survival network meta-analysis results for the intermediate-/poor-risk subgroup suggested that there was a numerical, but not statistically significant, improvement in the overall survival for patients treated with lenvatinib plus pembrolizumab compared with patients treated with cabozantinib or nivolumab plus ipilimumab. Because of within-trial proportional hazards violations or uncertainty regarding the validity of the proportional hazards assumption, the assessment group overall survival network meta-analysis results for the favourable-risk subgroup and the all-risk population should not be used to infer any statistically significant difference (or lack of statistically significant difference) for any of the treatment comparisons. Only one cost-effectiveness study was included in the assessment group review of cost-effectiveness evidence. The study was limited to the all-risk population, undertaken from the perspective of the US healthcare system and included comparators that are not recommended by the National Institute for Health and Care Excellence for patients with untreated advanced renal cell carcinoma. Therefore, the extent to which resource use and results are generalisable to the NHS is unclear. The assessment group cost-effectiveness results from the modified partitioned survival model focused on the intermediate-/poor-risk and favourable-risk subgroups. The assessment group cost-effectiveness results, generated using list prices for all drugs, showed that, for all comparisons in the favourable-risk subgroup, treatment with lenvatinib plus pembrolizumab costs more and generated fewer benefits than all other treatments available to NHS patients. For the intermediate-/poor-risk subgroup, treatment with lenvatinib plus pembrolizumab costs more and generated more benefits than treatment with cabozantinib and nivolumab plus ipilimumab. Good-quality clinical effectiveness evidence for the comparison of lenvatinib plus pembrolizumab with sunitinib is available from the CLEAR trial. For most of the assessment group Bayesian hazard ratio network meta-analysis comparisons, it is difficult to reach conclusions due to within-trial proportional hazards violations or uncertainty regarding the validity of the proportional hazards assumption. However, the data (clinical effectiveness and cost-effectiveness) used to populate the economic model are relevant to NHS clinical practice and can be used to inform National Institute for Health and Care Excellence decision-making. The assessment group cost-effectiveness results, generated using list prices for all drugs, show that lenvatinib plus pembrolizumab is less cost-effective than all other treatment options. This study is registered as PROSPERO CRD4202128587. This award was funded by the National Institute for Health and Care Research (NIHR) Evidence Synthesis Programme (NIHR award ref: NIHR134985) and is published in full in Health Technology Assessment; Vol. 28, No. 49. See the NIHR Funding and Awards website for further award information.

Islamic Economic Review of The Concept of Employee Wages (Case in Jakarta)

Research indicates that the concept of remuneration in Islamic economics emphasizes alignment with its principles. Workers are expected to maintain professionalism and avoid fraud. The primary aim of this remuneration concept is to enhance workers' well-being, reflecting a focus on community welfare and humanity rather than just profit. Entrepreneurs are encouraged to treat workers like family, fulfilling all their needs, and embodying the spirit of cooperation (ta'awun), ensuring no harm comes to any party. This ethos promotes collective responsibility in meeting the basic needs of the less fortunate. In the context of Place in Jakarta City, the remuneration model aligns with Islamic economic principles. Employee pay is based on customer percentage, encouraging each worker to contribute to the business's success. Salaries are adjusted according to the employees' skills and the number of customers they serve, resulting in variable wages rather than a fixed amount. This model ensures that remuneration is fair and reflects the employees' contributions, fostering a cooperative and supportive work environment consistent with Islamic values.

Legal Economic Review of the Fair Use System Under the Copyright Act

Legal Economic Review of the Fair Use System Under the Copyright Act

The Influence of Motivation, Religiosity and Work Environment on The Productivity of SME Actors In Islamic Economics Review

This study aims to determine the influence of motivation, religiosity, and work environment on the productivity of micro, small, and medium enterprises (MSMEs) in Gayo Lues Regency from the perspective of Islamic Economics. The research method used was quantitative research, utilizing primary data collected through questionnaire distribution to respondents, and secondary data sourced from the Ministry of Cooperatives and SMEs and literature studies from relevant books and research journals. Data analysis employed validity test, reliability test, classical assumption test, and hypothesis testing. The findings indicate that motivation does not significantly influence the productivity of MSMEs in Gayo Lues Regency. However, religiosity and work environment significantly influence MSMEs' productivity in Gayo Lues Regency. Simultaneously, motivation, religiosity, and work environment jointly affect productivity.

Monetary policy and heterogeneous price effects in the United Kingdom

AbstractThis paper examines the heterogeneous effects of monetary policy on consumer prices in the United Kingdom. We estimate a proxy Structural Vector Autoregressive (SVAR) model, using extended high‐frequency monetary surprises from Cesa‐Bianchi et al. (European Economic Review, 123, 2020, 103375) to instrument shifts in UK monetary policy. We then analyze the impulse responses for various components of the UK Consumer Price Index. Our findings reveal that while monetary policy tightening leads to a persistent decline in aggregate consumer prices, the impact on disaggregated components is highly heterogeneous. Notably, we observe that energy price changes offset movements in food, beverage, and tobacco prices, resulting in identical responses of core and headline consumer CPIH inflation measures. The contrasting effects across different CPI components highlight the importance of examining disaggregated data when assessing the transmission of monetary policy to consumer prices.

Publishing experiences of researchers in the developing world: An analysis of submissions to the Review of Development Economics, January 2015 to April 2022

AbstractResearchers based in poorer countries typically face major challenges in publishing their work in international journals, compared to those faced by researchers in the wealthier countries of Europe and North America. This paper studies this issue based on the experience of papers submitted to the Review of Development Economics, an important international development economics journal. It presents an analysis of submissions and success in publication, based on the fortunes of all papers submitted to the journal between 2015 and April 2022, disaggregated by the country in which the corresponding author is based. Authors based in low and middle income countries accounted for 33% of publications in this period, though they accounted for 61% of the submissions received. A main factor was that these papers were significantly less likely to be sent for review by the journal; if reviewed, they were also less likely to be accepted than papers from authors in high income countries, though that differential is much less stark. This analysis is presented in the interests of transparency and to encourage discussion, but also to raise issues the journal needs to address. The paper finishes by reviewing, based on co‐editor experience over this period, issues and potential responses.

Integration of Digestate-Derived Biochar into the Anaerobic Digestion Process through Circular Economic and Environmental Approaches-A Review.

The growing energy consumption and the need for a circular economy have driven considerable interest in the anaerobic digestion (AD) of organic waste, offering potential solutions through biogas and digestate production. AD processes not only have the capability to reduce greenhouse gas emissions but also contribute to the production of renewable methane. This comprehensive review aims to consolidate prior research on AD involving different feedstocks. The principles of AD are explored and discussed, including both chemical and biological pathways and the microorganisms involved at each stage. Additionally, key variables influencing system performance, such as temperature, pH, and C/N ratio are also discussed. Various pretreatment strategies applied to enhance biogas generation from organic waste in AD are also reviewed. Furthermore, this review examines the conversion of generated digestate into biochar through pyrolysis and its utilization to improve AD performance. The addition of biochar has demonstrated its efficacy in enhancing metabolic processes, microorganisms (activity and community), and buffering capacity, facilitating Direct Interspecies Electron Transfer (DIET), and boosting CH4 production. Biochar also exhibits the ability to capture undesirable components, including CO2, H2S, NH3, and siloxanes. The integration of digestate-derived biochar into the circular economy framework emerges as a vital role in closing the material flow loop. Additionally, the review discusses the environmental benefits derived from coupling AD with pyrolysis processes, drawing on life cycle assessment investigations. Techno-economic assessment (TEA) studies of the integrated processes are also discussed, with an acknowledgment of the need for further TEA to validate the viability of integrating the biochar industry. Furthermore, this survey examines the techno-economic and environmental impacts of biochar production itself and its potential application in AD for biogas generation, aiming to establish a more cost-effective and sustainable integrated system.

Penerapan Fungsi Retribusi Pasar Terhadap Layanan Infrastruktur Pedagang Pasar Tradisional di Desa Batetangngga (Perspertif Hukum Ekonomi Islam )

The research investigates the traditional market levy in Batetangngga Village from an Islamic legal perspective. The aim of this study is to understand the function of market levies in providing trading facilities in the market. With two problem formulations: 1) how is the application of traditional market levies in Batetangngga Village, 2) How is the economic legal review of traditional market levies in Batetangngga Village. This research is qualitative using interview and observation techniques, and the data processing and analysis methods used in compiling this thesis are editing and verification. The results show that market levies in traditional markets come from the collection of business rental fees, cleanliness levies, electricity levies, and parking levies. These levies vary for each trader and are divided into several groups. Facilities available in Batetangngga Village traditional market include toilets, parking areas, and waste disposal facilities. The collection of levies in this traditional market does not comply with Islamic economic law because there are conditions not met by market officials, namely responsibility for repair and maintenance. However, market officials are not responsible for repairing facilities that have been paid for by traders. Taking away others' rights and causing harm to traders whose rights are taken is akin to stealing others' property. Taking someone else's rights is tantamount to committing injustice, a prohibition mentioned in the Qur'an and the Hadith of the Prophet.

Understanding Gen Z’s Climate Anxiety: A Look at the Latest Research

Nowadays, the widespread availability of information on climate change has made up-to-date knowledge in this area more accessible to a broad section of society. At the same time, this information overload can potentially threaten psychological well-being. In particular, a specific form of anxiety, commonly known as climate (change) anxiety, is a substantial problem. Although climate anxiety terminology only became commonplace a few years ago, the phenomenon itself has older roots. It includes several responses to climate change, the complexity of which assumes more detailed knowledge. The fact that climate disasters are becoming more common may generate intense negative emotions such as fear, depression, tension, and rage. According to current studies, stress derived from climate change is most prevalent among Generation Z. This generation group is the focus of researchers due to their outstanding environmentally conscious approach. They are possibly expected to make the most important decisions in the future, and worries about climate change may significantly influence their decisions. Researchers need to analyze the multiple causes of this phenomenon and the actions they induce. This economic literature review aims to summarize the main observations from the international literature in this field.

TINJAUAN HUKUM EKONOMI SYARI’AH TERHADAP AKAD PERJANJIAN KERJA SAMA ANTARA PORTER DAN PT. KAI

The cooperative relationship between the company and the workers still leaves serious problems regarding the rights and obligations of each party, as well as what happens in the cooperative relationship between the porter and the company PT. KAI at Palembang Kertapati Station. This study aims to determine the mechanism of the work relationship between the porter and PT. KAI at Palembang Kertapati Station, knowing the role of porters in improving the service quality of PT. KAI at Palembang Kertapati Station, and knowing the sharia economic law review of the cooperation agreement between the porter and PT. KAI at Palembang Kertapati Station. The method used in this research is to use a qualitative approach. This type of research is field research. Sources of data used are primary data sources and secondary data sources. Respondents or informants in this study are people who have knowledge of the work of porters at Palembang Kertapati Station, and some of the porters themselves. Data collection techniques are carried out through observation, interview, and documentation techniques. The results of the analysis in the discussion can be concluded from several points, namely: First, the working relationship between the porter and PT. KAI at Palembang Kertapati Station is a volunteer worker at PT. KAI that works at Palembang Kertapati Station with a permit and coordination mechanism at the Head of Kertapati Station in Palembang. Second, the role of porters in improving the service quality of PT. KAI at Palembang Kertapati Station is to fulfill the vision of PT. KAI. And third, a review of sharia economic law on the cooperation agreement that if viewed based on the contract, the work agreement or syirkah (in Islamic view) that occurs between the porter and PT. KAI is a syirkah 'abdan / syirkah' charity, and if seen according to thecontract ijarah, even though in the working relationship between the porter and PT. KAI at Palembang Kertapati Station according to PT. KAI that porter is not part of PT. KAI and also not part of Palembang Kertapati Station, but the wages earned by porters are directly from passengers who use their services on the terms of the rates set by PT. KAI.

Islamic Economic Law Review: Application of Khiyar Rights to Brick Purchases

Islamic Economic Law Review: Application of Khiyar Rights to Brick Purchases

An Analytical Review of Language Economics with a Discussion on Language Use, Policy and Planning in Sri Lanka

Language dynamics depend not only on factors as explained by sociolinguists but also on economic factors. Economics of language and economic analysis of language provide analytical framework for language choice, use of language, language development, language and economic wellbeing, language assimilation, language death, etc. This paper discusses theoretical aspects of economics of language and how language dynamics and economic factors are interrelated with a discussion on language use in Sri Lanka. The paper surveys literature on economics of language which considers language as a rational choice. Optimal language choice maximizes economic benefits subject to constraints. If a language does not serve the need of the people, the evolutionary forces work to improve its functioning, thus language remains incomplete. In a framework of human development, language skills enhance economic gains. As per the discrimination theory, marginalization of minority language speakers from economic activities was analyzed. It was also discussed that economic factors drive a society with many languages to choose one common language or to retain or preserve endangered minority languages. Another branch of research focused on the analysis of official language policies of countries. These studies were highly useful in understanding the relationship between economic factors and language issues and resulting language policy planning. In the discussion on language use in Sri Lanka, it is found that official and link language policies do not always ensure equal access to economic opportunities for different language users. Lack of official data and extensive research on language aspects and their economic concerns further restrict the implementation of better language policy and finally resolving language issues.

P36 Unsupported Policy Information? The Institute for Clinical and Economic Review's Unsupported Price Increase Reports

P36 Unsupported Policy Information? The Institute for Clinical and Economic Review's Unsupported Price Increase Reports

HTA27 An Analysis of Manufacturer and Patient Engagement with Institute for Clinical and Economic Review Assessments

HTA27 An Analysis of Manufacturer and Patient Engagement with Institute for Clinical and Economic Review Assessments

EE104 Value Assessment of Emerging Treatments for Nonalcoholic Steatohepatitis: Lessons from Institute for Clinical and Economic Review Evaluations

EE104 Value Assessment of Emerging Treatments for Nonalcoholic Steatohepatitis: Lessons from Institute for Clinical and Economic Review Evaluations

Islamic Education in Gender Perspective (Historical, Sociological, Political, Economic and Management Review)

Islamic Education in Gender Perspective (Historical, Sociological, Political, Economic and Management Review)

Global economic contraction, climate change and the gold market volatility: A GARCH‐MIDAS approach

AbstractOur paper has two main objectives. First, we aim to investigate the relationship between global economic contraction (GECON) and the return volatility of gold. Second, we examine the role of climate change as a mediator in this connection. To achieve this, we use the GARCH‐MIDAS model, which accommodates data in different frequencies in the same model. This prevents the loss of important information when aggregating high‐frequency data to lower‐frequency data. We also use alternative measures of GECON from Kilian and Zhou (Journal of International Money and Finance, 2018; 88, 54–78) and Baumeister et al. (Review of Economics and Statistics, 2020;104(4), 828–844) to ensure the robustness of our findings. Our results show that global economic contraction positively impacts the return volatility of gold. Additionally, our findings confirm that the increased uncertainty caused by climate change makes gold a safe haven for investors. This means that gold's return volatility is not negatively impacted by the rising level of uncertainty caused by climate‐induced contraction. Moreover, we note that the index of GECON that accommodates more dynamics can produce more accurate predictability for gold market volatility. Our analysis of stock market volatility further confirms that gold has a safe haven potential relative to the stock market.

Regional economic development in the lens of the dilemma between growth poles approach and the balanced growth theory. An observatory during the Francoist regime

Regional economic development gained increasing relevance in European policy agendas after the Second World War, especially under the implementation of indicative planning. Likewise, a lively debate arose between the growth poles approach and the balanced growth theory. The main aim of this paper is to analyse this dilemma mainly through contributions from the Revista de Economía de Galicia (Galician Economic Review), as a representative observatory of this controversial discussion in the Francoist regime. National and international contributions underlined the positive potential effects of fostering an upgrading process of traditional sectors as a way of enhancing balanced and endogenous growth.

KarXT for schizophrenia-effectiveness and value: A summary from the Institute for Clinical and Economic Review's New England Comparative Effectiveness Public Advisory Council.

KarXT for schizophrenia-effectiveness and value: A summary from the Institute for Clinical and Economic Review's New England Comparative Effectiveness Public Advisory Council.

Xanomeline-Trospium in schizophrenia: A detailed review and comparison with the Institute for Clinical and Economic Review's analysis.

Xanomeline-Trospium in schizophrenia: A detailed review and comparison with the Institute for Clinical and Economic Review's analysis.