Among the several crises that occurred in the 16th century, the famine crisis and high prices in the years 1569–1574 had exceptional significance, as its intensity, scope and duration far out-weighed other economic collapses of the century. Despite this, the course of events and the consequences have been of virtually no interest to historians over the years, which begs the question: why? As it seems, the events connected with the crises in question were overshadowed in Western historiography by other numerous and significant political events at the time, such as the Battle of Lepanto (1571) and the Night of St. Bartholomew in France (1572). In the Polish-‑Lithuanian state, in contrast, between 1569 and 1574, the famine and high prices coincided with a crisis of royal power and the state. This, indeed, drew the attention of historians, but only to political issues, among them the Polish‑Lithuanian union of 1569, the succession to the throne after the heirless Sigismund Augustus died, the first free election, religious disputes, the flight of King Henryk Walezy (Henry III), and the neighbouring wars, rather than to the social problems connected with the mass death of the poorest in the state, and the resulting economic problems. Therefore, in this article, the author synthesises the course of the famine crisis of 1569–1574 in the Polish‑Lithuanian state and hypothesises that the events and implications of this crisis largely preserved the mentality of the nobility in the following centuries and their dominance in the economic and political life of the Commonwealth. This crisis also influenced a choice of different path for development of the Commonwealth compared to other European countries. To clarify, the author does not claim to have exhausted the subject, and the article is intended to spur a discussion and further detailed research.