In order to explore the training path of applied talents in line with the needs of social development, based on the concept of OBE, this paper analyzes and sorts out some problems faced in the training process of applied talents. Then, in order to solve these problems, the paper puts forward some countermeasures such as optimizing the curriculum system, innovating practical teaching and constructing project-based teaching. Finally, combining with the logistics engineering major of Liaoning Institute of Technology, the paper analyzes the implementation effect of the applied talent training mode based on the OBE concept. The results show that this model is helpful to improve the graduates' application ability and quality, and better carry out school-enterprise cooperation and promote regional economic development. At the same time, it provides reference for the reform of higher education and teaching.