The Strait of Malacca, an indispensable artery facilitating global trade, confronts an existential peril exacerbated by climate change. This research comprehensively analyses the intricate interplay between ecological and socioeconomic factors, with a primary focus on India’s vulnerabilities and adaptive strategies. The study scrutinizes the escalating sea levels, intensification of storms, and coastal erosion, elucidating their multifaceted impacts on ecosystems, communities, and economies. The Malacca Straits are one of the world’s most vulnerable areas because of their high potential for political conflict and ecological disaster. The areas bordering the Straits are of high bio-diversity and ecologically fragile. The imperative to foster resilience is underscored, necessitating the exploration of adaptive strategies to empower communities, preserve ecosystems, and foster sustainable development amidst climatic challenges. This research transcends conventional threat assessments, offering a holistic roadmap for India and stakeholders to navigate the complexities of climate change and ensure the enduring prosperity of the Strait of Malacca. It also delves specifically into the vulnerabilities faced by countries bordering the Strait, with a particular focus on India’s dependence on the waterway for trade, food security, and energy needs. The need of the hour is to analyse these vulnerabilities, and to pave the way for the development of robust adaptation strategies that ensure the long-term sustainability and resilience of the Strait of Malacca in the face of a changing climate.