This paper addresses the structural behaviour of profiled steel composite walls (PSCWs) infilled with foam rubberized concrete (FRC) under concentric, eccentric and flexural loads. FRC mechanical properties such as compressive strength, flexural strength, and splitting tensile strength are presented for different rubber contents; 0%, 50%, and 100% as sand replacement by volume. FRC with unit weight of 1000 kg/m3 and 50% rubber content was selected as the filler material. Three PSCWs were tested under concentric, eccentric compressive loads, and four-point bending loads. Finite element modelling (FEM) using ABAQUS software has been carried out to simulate the experimental behaviour of the PSCWs. Parametric study was carried out to investigate the effect of different concrete and steel strengths and steel sheet thicknesses. FEM results showed a good agreement with the experimental results. Practical formulas in terms of concrete strength, steel sheet buckling stress, wall geometry, and eccentricity are presented to predict interaction diagrams for PSCW structures.