Evaporative cooling is a natural, environment-friendly, and economical method of air-conditioning involving minimal energy consumption. However, the wider dependency on the climatic condition, lower cooling capacity, lesser effectiveness, excess humidification, etc., limits the evaporative coolers' global acceptance. Therefore, multi-staging of evaporative coolers or hybridization with any conventional direct expansion system is recognised as a solution for building air-conditioning. Accordingly, a three-stage cooling test rig comprising indirect and direct evaporative coolers followed by a direct expansion system is indigenously developed and efficacy of seven single to multi/hybrid modes is experimentally evaluated. Rigorous experiments are conducted during the entire summer of Hyderabad, India, from April to July of 2019 by operating the test rig from 20th to 26th of each month from 8:00 AM to 8:00 PM with an interval of one hour. Based on the acquired experimental data, energy, exergy, heat transfer and environmental analyses are carried out. The three-stage cooling combination exhibits the highest wet-bulb effectiveness reaching a maximum of 300% with the lowest supply air temperature of 16 °C. Multi-staging provides an average sensible cooling load reduction ranging from 15.21% to 65.04% on the direct expansion cooling system. Moreover, the two-stage indirect-direct evaporative cooler exhibits excellent exergy efficiency with sufficient cooling capacity reaching 90%. The DEC-DX, IEC-DEC and IEC-DEC-DX cooling combinations exhibit superior SEER magnitudes over entire cooling season indicating effectiveness of evaporative pre-cooling.