AbstractOver the past decade, the seismicity rate in the state of Oklahoma has increased significantly, which has been linked to industrial operations, such as saltwater injection and hydraulic fracturing. Taking advantage of induced earthquakes and recently deployed seismometers, we construct a 3‐D radially anisotropic seismic velocity model for the crust of Oklahoma by using full waveform inversion. To mitigate the well‐known cycle‐skipping problem, we use misfit functions based on phase and waveform differences in several frequency bands. Relative velocity perturbations in the inverted model allow us to delineate major geological provinces in Oklahoma, such as the Anadarko Basin and the Cherokee Platform/Shelf. In addition, radial anisotropy in the inverted model reflects deformation within the crust of Oklahoma, which might correlate with sedimentary layering, microcracks/fractures, as well as dominant orientation of anisotropic minerals. The crystalline basement beneath Oklahoma can be inferred from the new velocity model, which enables us to better classify induced seismicity in current earthquake catalogs. Furthermore, synthetic experiments suggest that the new velocity model enables us to better constrain earthquake locations in Oklahoma, especially for determining their depths, which are important for investigating induced seismicity.