Relevance. The relevance of the problem of the volemic status (VS) correction in patients with sepsis, especially with septic shock and multiple organ failure is beyond doubt, because in this condition there are always significant and life-threatening changes in homeostasis, especially in the circulatory system. At the same time, the percent of deaths remains high, and uncertainty in the pathophysiological mechanisms and an erased clinical picture can lead to untimely diagnosis and delayed correction of circulating blood volume (CBV).Aim of research. To analyze and summarize current concepts about the assessment of CBV in sepsis and septic shock. To identify current approaches to infusion therapy in this pathology in order to increase the efficiency of treatment and knowledge of specialists.Materials and methods. During writing the article, the search for literary sources was carried out in the databases: PubMed, eLibrary, CyberLeninka over the past 5 years, as well as from earlier sources that have not lost their relevance. At the same time, free access to the full content of publications was used in accordance with the subject of the review.Conclusion. The choice of infusion therapy tactics for patients with sepsis and polymorbidity may present significant difficulties due to the limited number of methods for monitoring and correcting volemic status. At the same time, the difficulty of making a decision is due to the multifactorial nature of the parameters and the inconsistency of the results obtained. In this situation, the result of treatment can be improved by using a combined analysis of parameters, prioritizing dynamic rather than static indicators. Methods of research and control of VS based on ultrasound technologies are more accessible and preferable in use for most medical preventive institutions (MPI) to determine the strategy of infusion therapy in the treatment of sepsis. The topic of control and correction of volemic status needs further research.
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