eLife Research Articles

Yin and yang of hair cells

Neurodevelopment The sensory hair cells housed in the inner ear develop sequentially in organized rows. The progenitor cells exit the cell cycle in order and then differentiate in the opposite order. Prajapati-DiNubila et al. show that the cytokine activin A and its antagonist follistatin regulate expression of the transcription factor ATOH1 and thus of hair cell differentiation. Activin A activated expression of ATOH1, whereas follistatin reduced its expression. Similarly, follistatin signaling regulated the number of inner hair cells. eLife 10.7554/eLife.47613 (2019).

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eLife is publishing a collection of articles and interviews with scientists who are parents to explore how to get the best of both worlds.

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When assessing manuscripts eLife editors look for a combination of rigour and insight, along with results and ideas that make other researchers think differently about their subject.

"interactive" version of data associated with the eLife paper "Integrative genomic analysis of the human immune response to influenza vaccination"

"interactive" version of data associated with the eLife paper "Integrative genomic analysis of the human immune response to influenza vaccination"

The Second A-SSCC Considers Challenges for the e-Life

The Second A-SSCC Considers Challenges for the e-Life

AI Meets Web 2.0: Building the Web of Tomorrow, Today

Imagine an Internet-scale knowledge system where people and intelligent agents can collaborate on solving complex problems in business, engineering, science, medicine, and other endeavors. Its resources include semantically tagged websites, wikis, and blogs, as well as social networks, vertical search engines, and a vast array of web services from business processes to AI planners and domain models. Research prototypes of decentralized knowledge systems have been demonstrated for years, but now, thanks to the web and Moore's law, they appear ready for prime time. This article introduces the architectural concepts for incrementally growing an Internet-scale knowledge system and illustrates them with scenarios drawn from e-commerce, e-science, and e-life.

10.7554/eLife.02043.017

10.7554/eLife.02043.017

10.7554/eLife.02043.018

10.7554/eLife.02043.018