Dynamic Process Research Articles

The AutoSpawner system - Automated ex situ spawning and fertilisation of corals for reef restoration

The restoration of reefs damaged by global and local pressures remains constrained by the scale of intervention currently feasible. Traditional methods for ex situ sexual propagation of corals produce limited materials, typically of limited genetic diversity and only sufficient for small field trials. The development and validation of new technologies to upscale and automate coral propagation is required to achieve logistically and financially feasible reef restoration at ecologically relevant scales. To address the need for upscaled production of genetically diverse material for use in reef restoration we designed an automated system (the AutoSpawner) for harvesting, fertilising and washing gametes from tropical broadcast-spawning corals. The system includes a novel high density dynamic fertilisation process, which enables the production of large numbers of fertilised coral eggs (>7 million per night for highly fecund species) without any downstream negative effects on larval quality. The functionality of the system and the quality of the produced larvae was assessed using multiple species from two coral families (Acroporidae and Merulinidae) across a range of spawning and gamete characteristics. We present the schematics and protocols required for automated sexual propagation of high-quality coral larvae using this novel system; and demonstrate that the time demands, and labour costs, associated with traditional manual-based sexual propagation of corals can be reduced by up to 113-fold using the AutoSpawner.

Optimal Control of the Dynamics of Physical and Chemical Processes of Blending and Melting of Copper Concentrates

This paper presents the developed model of dynamics of the physicochemical processes of electromelting of copper concentrates, which was obtained taking into account the available a priori information, which makes allowance for the main features of an object and describes the change of the basic variables of the process state (quantitative aspects of material flows and power, the composition of charge, matte, and slag). Such a model can be used in the field of automation of technological processes in metallurgical and mechanical engineering, and manufacturing. Due to the complexities of the technological process, it was advisable to use classical methods.

Negotiating Work and Family Spheres: The Dyadic Effects of Flexible Work Arrangements on Fertility Among Dual-Earner Heterosexual Couples.

Academics and policymakers have suggested making flexible work arrangements (FWAs) the default in workplaces to promote a family-friendly workplace culture conducive to having and raising children. However, systematic research investigating how FWAs, as a long-term approach to negotiating work-family spheres, are related to fertility among dual-earner heterosexual couples is limited. Drawing on the linked-lives perspective, we theorize the relationship between FWAs and fertility among couples and potential variation depending on the interplay of both spouses' work and family characteristics. We test our hypotheses using longitudinal couple-level dyadic data in the United Kingdom (2010-2022). We find that although FWA availability alone is unrelated to fertility, wives' (not husbands') FWA use is significantly associated with a higher probability of experiencing a first birth. Moreover, the effect of wives' FWA use is particularly pronounced when both spouses work in professional and managerial occupations and when husbands contribute a larger proportion of income and at least equal housework. This study reveals a gendered effect of FWAs on fertility across work-family arrangements, deepening our understanding of couple-level dynamics in the fertility process.

Evaluating Stakeholders’ Decisions in A Blockchain-Based Recycling Construction Waste Project: A Hybrid Evolutionary Game and System Dynamics Approach

To promote efficient construction waste recycling and reuse, a novel waste management approach based on blockchain technology was introduced to the industry. However, adopting blockchain platforms in construction waste recycling and reuse may impact the behavioral strategies of stakeholders and impede the prediction of the specific impacts of stakeholders’ decisions. Accordingly, this study addresses two primary questions: (1) What are the collaborative framework and the behavioral evolution trends of multiple stakeholders within the context of blockchain? (2) How can the behavioral strategies of multiple stakeholders be systematically coordinated to achieve efficient construction waste recycling and reuse driven by blockchain? To answer these questions, a tripartite game model combined with system dynamics was constructed. In this model, we aimed to elucidate the internal organizational framework, analyze the dynamic evolution process, and assess the influence of decisions made by multiple stakeholders at the individual level. It also offers corresponding policy recommendations for efficient construction waste recycling and reuse driven by blockchain at the system level. This study offers three innovations. First, it considers the decision-making of multiple stakeholders as an interdependent and coevolutionary process to overcome the defects of analyzing only one type of participant. Second, in contrast to the static analysis method, it employs a dynamic system approach to deeply analyze the evolving structures of blockchain-based projects. Third, it provides a theoretical framework for the practical implementation of blockchain-driven platforms in managing construction waste recycling and reuse, thus fostering effective policy development and management practices. This framework aims to promote sustainable development in construction waste recycling and reuse projects in China as well as globally.

Investigation of sorptive interactions between volatile organic compounds and supramolecules at dynamic oscillation using bulk acoustic wave resonator virtual sensor arrays

Supramolecules are considered as promising materials for volatile organic compounds (VOCs) sensing applications. The proper understanding of the sorption process taking place in host-guest interactions is critical in improving the pattern recognition of supramolecules-based sensing arrays. Here, we report a novel approach to investigate the dynamic host-guest recognition process by employing a bulk acoustic wave (BAW) resonator capable of producing multiple oscillation amplitudes and simultaneously recording multiple responses to VOCs. Self-assembled monolayers (SAMs) of β-cyclodextrin (β-CD) were modified on four BAW sensors to demonstrate the gas-surface interactions regarding oscillation amplitude and SAM length. Based on the method, a virtual sensor array (VSA) type electronic nose (e-nose) can be realized by pattern recognition of multiple responses at different oscillation amplitudes of a single sensor. VOCs analysis was realized respectively by using principal component analysis (PCA) for individual VOC identification and linear discriminant analysis (LDA) for VOCs mixtures classification.

Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma.

RNA splicing is a dynamic molecular process in response to environmental stimuli and is strictly regulated by the spliceosome. Sm proteins, constituents of the spliceosome, are key components that mediate splicing reactions; however, their potential role in hepatocellular carcinoma (HCC) is poorly understood. In the study, SNRPD2 (PD2) is found to be the most highly upregulated Sm protein in HCC and to act as an oncogene. PD2 modulates DDX39A intron retention together with HNRNPL to sustain the DDX39A short variant (39A_S) expression. Mechanistically, 39A_S can mediate MYC mRNA nuclear export to maintain high MYC protein expression, while MYC in turn potentiates PD2 transcription. Importantly, digitoxin can directly interact with PD2 and has a notable cancer-suppressive effect on HCC. The study reveals a novel mechanism by which DDX39A senses oncogenic MYC signaling and undergoes splicing via PD2 to form a positive feedback loop in HCC, which can be targeted by digitoxin.

Material matters: understanding ‘local food’ through a material-semiotic approach

‘Local food’ plays a critical role in tourism destinations by attracting tourists and enhancing their experiences, thus indicating the need for researchers to examine how destinations can establish local food. Research has focused on the social and cultural construction of local food, but there have been limited inquiries into how the materiality of food is intertwined with human practices in the process. This perspective has hindered new insights into the becoming of local food in tourism destinations. This study conceptualises local food as an effect of an actor-network and investigates the dynamic and relational process of the becoming of local food in a tourism destination. In particular, this research selected Chaozhou beef food as a case and collected data through 49 on-site semi-structured interviews, in-situ observations and secondary data. The results reveal that the becoming of Chaozhou’s local food is due to the entanglement of both human actors, including tourists, artisans in slaughterhouses and staff in restaurants, and non-human actors such as the media, chain restaurants specialising in beef, tourism attractions and the beef itself. Further, the results reveal that the materiality of beef, namely the features of biochemical change and the morphological structure of beef, shapes the slaughterhouses’ and restaurants’ production and the tourists’ consumption of beef. Thus, the agency of material should be considered in the construction and sustainability of local food in tourism destinations.

Electrochemical treatment of azo dye wastewater by dynamic flow diaphragm system: Response surface methodology optimization and energy consumption analysis

In this experiment, the degradation process of azo dye wastewater was studied based on the diaphragm double chamber electrochemical reactor, taking the mono azo dye amaranth as an example. Through the circulation flow of appropriate volume of wastewater in the cathode and anode chamber, the simultaneous action of cathode and anode was realized, and the degradation and decolorization efficiency of azo wastewater was improved while reducing energy waste. The optimal reaction conditions optimized by response surface methodology were as follows: the voltage was 20.74 V, the plate spacing was 4.89 cm, and the cycle speed was 60.66 rad / min. The optimal decolorization rate was 99.66 %. The energy consumption analysis of the dynamic flow diaphragm system electrochemical method and the static flow diaphragm system electrochemical method for the treatment of azo dye wastewater was compared and analyzed. In addition, the possible degradation process of azo dye wastewater by dynamic flow electrochemistry was inferred by ultraviolet spectroscopy and mechanism prediction analysis. The experimental results show the great potential of the dynamic flow membrane system process in the treatment of azo dyes.

Theoretical Study of Molybdenum Separation from Molybdate Assisted by a Terahertz Laser.

Molybdenum (Mo) is a rare and important element extensively utilised in aerospace, radar communications, optoelectronic devices, and the military. This study proposes an environmentally friendly physical method based on photon-phonon resonance absorption for the separation of Mo from sodium molybdate (Na2MoO4). We examined the vibrational spectrum of Na2MoO4 using the CASTEP code, employing first-principles density functional theory. Through dynamic process analysis, we analysed the vibrational modes and assigned peaks corresponding to experimental infrared (IR) and Raman data. We focused on the vibrational modes associated with Mo and identified that the highest-intensity IR-active peak at 858 cm-1 corresponded to Mo-O bond asymmetric stretching. Therefore, we propose the use of a high-power terahertz laser at ~25 THz to facilitate the separation of Mo from Na2MoO4. Experimental investigations are expected in the future.

The Nature of Pointer States and Their Role in Macroscopic Quantum Coherence

This article begins with an interdisciplinary review of a hydrodynamic approach to understanding the origins and nature of macroscopic quantum phenomena in high-temperature superconductivity, superfluidity, turbulence and biological systems. Building on this review, we consider new theoretical insights into the origin and nature of pointer states and their role in the emergence of quantum systems. The approach includes a theory of quantum coherence underpinned by turbulence, generated by a field of pointer states, which take the form of recirculating, spin-1/2 vortices (toroids), interconnected via a cascade of spin-1 vortices. Decoherence occurs when the bosonic network connecting pointer states is disrupted, leading to their localisation. Building further on this work, we explore how quantum particles (in the form of different vortex structures) could emerge as the product of a causal dynamic process, within a turbulent (fractal) spacetime. The resulting particle structures offer new insights into intrinsic spin, the probabilistic nature of the wave function and how we might consider pointer states within the standard “point source” representation of a quantum particle, which intuitively requires a more complexed description.

Multi-Physics Coupling in IGBT Modules: A Review

Abstract Since insulated gate bipolar transistor (IGBT) is a core component for power conversion in a power electronic system, guaranteeing the safety of IGBT becomes a crucial task for the maintenance of the power system. However, the mechanism of IGBT failure is a considerably complicated process related to the dynamic process, involving electric, thermal, and force. Hence, understanding the behaviors of IGBT under multi-physics field coupling plays an important role in the design and reliability studies of IGBT. In this paper, we review the multi-physics coupling effects, namely, electric-thermal coupling, thermal-force coupling, and force-electric coupling, inside IGBT devices. The basic principles of each coupling, coupling models, application occasions as well as key issues and development trends are discussed in detail, respectively.

Dynamic flood mapping by a normalized probabilistic classification method using satellite radar amplitude time series

ABSTRACT Owing to the vast development of Synthetic Aperture Radar (SAR), especially the improvement of spatio-temporal resolution, observing and quantifying the complex and dynamic flood process becomes increasingly feasible. Utilizing the Sentinel-1 Ground Range Detected (GRD) dataset, we proposed an improved probabilistic flood mapping method combining image Pareto Scaling (PS) normalization and Bayesian probability estimation. We validated our method during a flood event in Xinjiang County, Shaanxi Province of China in October 2021 using a high spatial resolution (0.1 m) Unmanned Aerial Vehicle (UAV) image. The overall reliability of the new method agrees 95% to the UAV measurements and achieves the highest accuracy (85.2%) when compared to the Sentinel-1 dual-polarized water index (SDWI) threshold method and the Z-score method. Our results distinguished four flood stages: flood emergence, peak, receding, and disappearance, which provide valuable insights into the dynamic change process of floods. Notably, we observed that pixels with different flood probabilities exhibited distinct temporal characteristics. The extremely high probability pixel experienced rapid fluctuations, while the medium probability pixel showed more gradual changes over time. We believe our proposed method can enhance our understanding of flood-prone areas and their dynamics so that decision-makers can develop targeted mitigation measures and response plans.

The Interplay of Atherothrombotic Factors and the Evolving Landscape of Atherosclerotic Cardiovascular Disease: Comprehensive Insights from Recent Studies.

The aim of the current work is to present a thorough recapitulation of the emerging understanding of atherosclerotic cardiovascular disease and recommending avenues for future studies. Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality, influenced by a complex interplay of genetic, environmental, and atherothrombotic factors. Atherosclerosis, a multifaceted and dynamic process, is at the core of many CVDs. Recent studies have shed light on the multilayered nature of atherosclerosis and cardiovascular risk, emphasizing the need for a nuanced understanding of these diseases across different populations and disease mechanisms. This review synthesizes findings from 6 pivotal studies, shedding light on the intricate mechanisms underlying atherosclerotic cardiovascular events, the evolving understanding of atherosclerosis, and the potential pathways to attempt implementation in clinical practice. Insights into atherothrombotic factors, the role of macrophages, and the implications of aortic enlargement and coronary artery calcification underscore the complexity of CVD pathogenesis and highlight the need for comprehensive strategies in diagnosis, treatment, and prevention.

A Clinician's Guide To Effectively Transitioning and Transferring Care For Pediatric Patients With Inflammatory Bowel Diseases From The Pediatric To Adult Gastroenterologist.

Transition of care for pediatric patients with inflammatory bowel diseases (IBD) is a continuous, dynamic process that takes place over several years with a coordinated approach executed by a multidisciplinary team. We review the concepts, tools, and research in effective transitioning and transfer of care for adolescent/young adult patients with IBD. Given the constraints within the healthcare system, effective transitioning can be challenging to implement in everyday clinical practice. Different barriers include resources and expertise in effective transitioning by pediatric and adult gastroenterology healthcare providers and the impact of non-gastrointestinal issues facing young adult patients who are learning to manage and coordinate all aspects of their medical care and health maintenance. Factors that facilitate successful care transitioning and transfer include structured transitioning programs, utilization of validated transition checklists, and IBD medical summaries. Proactive transitioning by pediatric gastroenterologists in partnership with their emerging young adult patients with IBD leads to better clinical and psychosocial outcomes and ultimately, effective transfer of care to adult gastroenterology. By utilizing utilize comprehensive transition assessment tools and medical summaries in partnership with their patients, pediatric and adult gastroenterology teams can better prepare patients as they transfer to independent care and health maintenance.

Novel Biomaterials for Wound Healing and Tissue Regeneration.

Skin is the first defense barrier of the human body, which can resist the invasion of external dust, microorganisms and other pollutants, and ensure that the human body maintains the homeostasis of the internal environment. Once the skin is damaged, the health threat to the human body will increase. Wound repair and the human internal environment are a dynamic process. How to effectively accelerate the healing of wounds without affecting the internal environment of the human body and guarantee that the repaired tissue retains its original function as much as possible has become a research hotspot. With the advancement of technology, researchers have combined new technologies to develop and prepare various types of materials for wound healing. This article will introduce the wound repair materials developed and prepared in recent years from three types: nanofibers, composite hydrogels, and other new materials. The paper aims to provide reference for researchers in related fields to develop and prepare multifunctional materials. This may be helpful to design more ideal materials for clinical application, and then achieve better wound healing and regeneration effects.

Genetic Contributions on Attachment in Emerging Adults: Cumulative Effects of Serotonergic Polymorphisms.

Attachment in emerging adults is closely intertwined with emotion regulation, stress coping, and social bonding during the transition from childhood to early adulthood. Due to the critical roles of serotonin in these mental functions, this research explored whether the cumulative genetic effects of serotonergic polymorphisms are associated with individual differences and contextual variations in attachment dimensions over time in emerging adults. Study 1 utilized a cross-sectional design in college students (N = 1088, mean age = 22.71 ± 2.86 years). The results showed significant correlations between a higher cumulative genetic score and elevated levels of attachment anxiety and avoidance. Study 2 employed a three-wave longitudinal design in a cohort of freshmen (N = 523, mean age = 19.54 ± 1.86 years at wave 1). The results demonstrated that a higher genetic score was associated with both higher levels and greater variability in attachment dimensions compared to a lower genetic score. These findings suggest that the cumulative genetic effects of serotonergic polymorphisms contribute to individual differences and dynamic processes in attachment dimensions in emerging adults.

Characteristics of Center-blast Tube with V-grooves During Blasting

The prediction of fracture time and crack development of metal shell under the impact load is a very significant research direction in engineering. In this paper, a coupling method is used to solve the dynamic expansion fracture process of center-blast tube with V-grooves under the pressure. A one-dimensional two-fluid model was utilized to govern the transient combustion. The nonlinear mechanical behaviors were predicted based on the finite element software ABAQUS, and the pressure and the structure were coupled by applying a user subroutine interface VUAMP in ABAQUS. The coupling approach was validated by comparing the predicted results with experimental results. Based on the validated approach, the characteristics of expansion fracture and the process of crack propagation on the center-blast tube with V-grooves were studied, and the effect grooves depth were analyzed. The results show that the crack propagation on tube can be divided into two stages that stable propagation stage and unstable propagation stage. The burst pressure of the center-blast tube with V-grooves decreases with the increase of crack depth, and the burst pressure decreases by about 7MPa with every depth increase of 0.25mm.

De-implementation strategy to reduce unnecessary antibiotic prescriptions for ambulatory HIV-infected patients with upper respiratory tract infections in Mozambique: a study protocol of a cluster randomized controlled trial

BackgroundAntibiotics are globally overprescribed for the treatment of upper respiratory tract infections (URTI), especially in persons living with HIV. However, most URTIs are caused by viruses, and antibiotics are not indicated. De-implementation is perceived as an important area of research that can lead to reductions in unnecessary, wasteful, or harmful practices, such as excessive or inappropriate antibiotic use for URTI, through the employment of evidence-based interventions to reduce these practices. Research into strategies that lead to successful de-implementation of unnecessary antibiotic prescriptions within the primary health care setting is limited in Mozambique. In this study, we propose a protocol designed to evaluate the use of a clinical decision support algorithm (CDSA) for promoting the de-implementation of unnecessary antibiotic prescriptions for URTI among ambulatory HIV-infected adult patients in primary healthcare settings.MethodsThis study is a multicenter, two-arm, cluster randomized controlled trial, involving six primary health care facilities in Maputo and Matola municipalities in Mozambique, guided by an innovative implementation science framework, the Dynamic Adaption Process. In total, 380 HIV-infected patients with URTI symptoms will be enrolled, with 190 patients assigned to both the intervention and control arms. For intervention sites, the CDSAs will be posted on either the exam room wall or on the clinician´s exam room desk for ease of reference during clinical visits. Our sample size is powered to detect a reduction in antibiotic use by 15%. We will evaluate the effectiveness and implementation outcomes and examine the effect of multi-level (sites and patients) factors in promoting the de-implementation of unnecessary antibiotic prescriptions. The effectiveness and implementation of our antibiotic de-implementation strategy are the primary outcomes, whereas the clinical endpoints are the secondary outcomes.DiscussionThis research will provide evidence on the effectiveness of the use of the CDSA in promoting the de-implementation of unnecessary antibiotic prescribing in treating acute URTI, among ambulatory HIV-infected patients. Findings will bring evidence for the need to scale up strategies for the de-implementation of unnecessary antibiotic prescription practices in additional healthcare sites within the country.Trial registrationISRCTN, ISRCTN88272350. Registered 16 May 2024, https://www.isrctn.com/ISRCTN88272350

Reconfiguring digital embeddedness in hybrid work: The case of employee experience management platforms

AbstractAs organisations respond to the increasing preference for hybrid work, employee experience management (EXM) platforms are becoming integral to transforming employees' experiences in hybrid workplaces. In this article, we theorise that EXM platforms are implanted into the workflow through digital embeddedness, which is appropriated and reconfigured through the interactions between human and digital subsystems in hybrid work. We adopt the lens of digital/human interaction to explore the reciprocal process of how EXM platforms configure and are reconfigured in hybrid work. Based on a case study of Microsoft Viva, an AI‐based EXM platform, we propose a conceptual model that identifies two dimensions of digital embeddedness: digital/human embeddedness and digital/workplace embeddedness. The study contributes to a theoretical understanding of digital embeddedness as a dynamic process whilst also showing the reconfiguration of hybrid work practices evidences a joint optimization. The study further contributes insights into how hybrid work, which resulted from the enforced remote work during the COVID‐19 pandemic, continues to emerge due to the digital embeddedness of EXM platforms in the flow of hybrid work.

Challenging assumptions: "unveiling meritocracy's reality in neurosurgery".

Meritocracy, a concept revered as the cornerstone of fairness and equal opportunity, is critically examined in the context of neurosurgery. This article challenges the notion that success in this demanding field is solely determined by individual abilities and effort. It reveals that factors such as background, gender, and socioeconomic status significantly influence one's career trajectory. By investigating how these systemic barriers impact admissions to neurosurgical training programs and professional advancement, the paper underscores the complexity of meritocracy in neurosurgery, suggesting that the meritocratic ideal is more nuanced and influenced by external variables than commonly believed. Certain universities deemed elite offer a curriculum divergent from that of their counterparts in low and middle-income countries. Students at these "elite" institutions gain exposure to new technologies and research incentives, which brings us to the realm of research. Remarkably, 75% of articles originating from developed nations account for just 25% of traumatic brain injury cases. This disparity highlights a significant research imbalance, and the common refrain underscores the need to bolster research capabilities in low-income countries. For neurosurgeons in the developing world, engaging in research often becomes a luxury due to multifaceted challenges. Financial barriers, including publication costs and paywalls for accessing articles, pose significant hurdles. Comparing salaries between countries underscores the glaring divide according to "Neurosurgeon Salary" in 2024. Neurosurgeons in the United States receive a median salary of $412,000 dollars per year, compared to $13,200 dollars in Latin America, as of June 2023. Given such incongruities, the prospect of even attending conferences or workshops abroad remains difficult for neurosurgeons from developing nations. Research isn't cast aside due to a lack of interest but due to resource limitations. The present landscape demands reconsideration. We underscore the journey towards a more inclusive and equitable future in neurosurgery as not just a goal, but a dynamic process fuelled by resilience, collaboration, and a commitment to diversity. The narrative promotes a collective endeavour to dismantle barriers and embrace innovation, emphasizing the importance of mentorship, cross-institutional collaboration, and the amplification of underrepresented voices.