Neurodynamical systems have gradually become a popular research topic owing to their broad applications in such fields as optimization, linear and nonlinear programming, associative memory, pattern recognition, and computer vision. In view of some inevitable factors, there have been formed various neurodynamical systems including delayed neural networks, stochastic neural networks, impulsive neural networks, reaction-diffusion neural networks, and fuzzy neural networks. Over the last few decades, considerable attention has been devoted to this research area not only for enriching the theory of differential equations and dynamical systems but also for deeply understanding the dynamic states of neural networks for better modelling the brain. The current special issue puts its emphasis on the study of neurodynamical system theory and applications. Call for papers has been carefully prepared by the guest editors and posted on the journal’s web page, which has received many attentions followed by some submissions among wide topics such as delayed neural systems, stochastic neural systems, impulsive neural systems, reaction-diffusion neural systems, fuzzy neural systems, evolutionary neural systems, mathematical modeling of neural systems, computational neuroscience, neurodynamical optimization and adaptive dynamic programming, cognitive models, pattern recognition, and neural network applications. All manuscripts submitted to this special issue went through a thorough peer-refereeing process. Based on the reviewers’ reports, eleven original research articles are finally accepted. The contents embrace the synchronization of coupled neural networks, the numerical analysis of stochastic delayed partial differential equations, and the stability analysis of delayed impulsive reaction-diffusion neural networks and switched neural networks. It is certainly impossible to provide in this short editorial a more comprehensive description for all articles in this special issue. However, the team of the guest editors believes that the results included reflect some recent trends in research and outline new ideas for future studies of neurodynamical system theory and applications.