The scenario of a single-mode cavity with harmonically modulated frequency is revisited in the presence of strongly detuned qubit or cyclic qutrit. It is found that when the qubit frequency is close to $3\ensuremath{\nu}$ there is a peak in the photon generation rate via four-photon transitions for the modulation frequency $4\ensuremath{\nu}$, where $\ensuremath{\nu}$ is the average cavity frequency. Effective five-photon processes can occur for the modulation frequency $5\ensuremath{\nu}$ in the presence of a cyclic qutrit, and the corresponding transition rates exhibit series of peaks. Closed analytical description is derived for the unitary evolution, and numeric simulations indicate the feasibility of multiphoton dynamical Casimir effect under weak dissipation.