In recent decades, risk of job loss in America after age 50 has been high, potentially causing significant stress during the period preceding retirement. Yet no study has quantified the burden of clinically relevant depressive symptoms attributable to job loss in this age group over this period or identified the most vulnerable populations. Participants aged 50+ in the Health and Retirement Study (recruited 1992-2016) who were employed and scored <5 on the Center for Epidemiologic Studies Depression 8-item scale (CESD-8) at baseline (N=18,571) were followed for depressive symptoms until they first had CESD-8≥5 or died, or through the 2018 survey. Parametric g-formula analyses examined the difference in cumulative risk of having CESD-8≥5 if there had been no involuntary job loss compared to the observed scenario, adjusting for sex, race/ethnicity, age, and dynamic measures of recent marriage end (divorce or widowhood), having a working spouse, assets/debt, and health changes. We estimated that risk of CESD-8≥5 would have been 1.1% (95%CI[0.55,1.37]) lower if no involuntary job loss had occurred; job loss accounted for 11% of the total burden among those who lost a job. Stronger associations were observed for women (1.2% [0.7,1.8] vs. men 0.5% [0.2,1.1]), white respondents (1.0% [0.6,1.5] vs. Black respondents 0.5% [-0.1,1.4]), and those in the lowest quartile of baseline assets (1.1% [0.4,1.9] vs. wealthiest quartile 0.5% [-0.4,0.9]). Involuntary job loss is associated with high depressive symptom burden in older persons, suggesting that screening and intervention soon after job loss may help mitigate depression.