Plateau Duration Research Articles

SN 2013ab: a normal Type IIP supernova in NGC 5669

We present densely-sampled ultraviolet/optical photometric and low-resolution optical spectroscopic observations of the type IIP supernova 2013ab in the nearby ($\sim$24 Mpc) galaxy NGC 5669, from 2 to 190d after explosion. Continuous photometric observations, with the cadence of typically a day to one week, were acquired with the 1-2m class telescopes in the LCOGT network, ARIES telescopes in India and various other telescopes around the globe. The light curve and spectra suggest that the SN is a normal type IIP event with a plateau duration of $ \sim80 $ days with mid plateau absolute visual magnitude of -16.7, although with a steeper decline during the plateau (0.92 mag 100 d$ ^{-1} $ in $ V $ band) relative to other archetypal SNe of similar brightness. The velocity profile of SN 2013ab shows striking resemblance with those of SNe 1999em and 2012aw. Following the Rabinak & Waxman (2011) prescription, the initial temperature evolution of the SN emission allows us to estimate the progenitor radius to be $ \sim $ 800 R$_{\odot}$, indicating that the SN originated from a red supergiant star. The distance to the SN host galaxy is estimated to be 24.3 Mpc from expanding photosphere method (EPM). From our observations, we estimate that 0.064 M$_{\odot}$ of $^{56}$Ni was synthesized in the explosion. General relativistic, radiation hydrodynamical modeling of the SN infers an explosion energy of $ 0.35\times10^{51} $ erg, a progenitor mass (at the time of explosion) of $ \sim9 $ M$_{\odot}$ and an initial radius of $ \sim600 $ R$_{\odot}$.

Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin.

Volume transmission results in phasic and tonic modulatory signals. The actions of tonic dopamine (DA) at type 1 DA receptors (D1Rs) are largely undefined. Here we show that tonic 5nM DA acts at D1Rs to stabilize neuronal output over minutes by enabling activity-dependent regulation of the hyperpolarization activated current (I h). In the presence but not absence of 5nM DA, I h maximal conductance (G max) was adjusted according to changes in slow wave activity in order to maintain spike timing. Our study on the lateral pyloric neuron (LP), which undergoes rhythmic oscillations in membrane potential with depolarized plateaus, demonstrated that incremental, bi-directional changes in plateau duration produced corresponding alterations in LP I hG max when preparations were superfused with saline containing 5nM DA. However, when preparations were superfused with saline alone there was no linear correlation between LP I hGmax and duty cycle. Thus, tonic nM DA modulated the capacity for activity to modulate LP I h G max; this exemplifies metamodulation (modulation of modulation). Pretreatment with the Ca2+-chelator, BAPTA, or the specific PKA inhibitor, PKI, prevented all changes in LP I h in 5nM DA. Calcineurin inhibitors blocked activity-dependent changes enabled by DA and revealed a PKA-mediated, activity-independent enhancement of LP I hG max. These data suggested that tonic 5nM DA produced two simultaneous, PKA-dependent effects: a direct increase in LP I h G max and a priming event that permitted calcineurin regulation of LP I h. The latter produced graded reductions in LP I hG max with increasing duty cycles. We also demonstrated that this metamodulation preserved the timing of LP’s first spike when network output was perturbed with bath-applied 4AP. In sum, 5nM DA permits slow wave activity to provide feedback that maintains spike timing, suggesting that one function of low-level, tonic modulation is to stabilize specific features of a dynamic output.

THE ROLE OF GASOTRANSMITTERS IN REGULATING OF THE FUNCTIONS OF SMOOTH MUSCLES: THE POSSIBLE EFFECTOR SYSTEMS

Influence of gasotransmitters carbon monoxide (CO) and hydrogen sulfide (H 2 S) on the electrical and contractile activities of smooth muscle cells (SMCs) of the guinea pig ureter and rat aorta were studied by methods of double sucrose bridge and mechanography. It has been shown that CO causes a dose-dependent decrease of the contractile response of SMCs of the ureter and rat aorta and also reduces the amplitude and duration of the action potential plateau. Against the background of the action of biologically active substances, agonists α1-adrenergetic and H1-histaminergetic receptors (phenylephrine and histamine, respectively), these effects of CO donor (CORM II) were amplified. The inhibitory effect of CO on the parameters of the contractile and electrical activities of smooth muscles is attenuated by blocking potassium channels of plasma membrane with tetraethylammonium (TEA) or inhibition of soluble guanylate cyclase (ODQ [1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-l-one]). Thus, the effects of carbon monoxide on the electrical and contractile activities of SMCs are associated with an increase potassium conductivity of the membrane or the activation of soluble guanylate cyclase. In experiments with a donor of hydrogen sulfide (NaHS), it was shown, that it has an activating effect on the electrical and contractile activities of smooth muscles of the guinea pig ureter, which is caused by the action of potassium conductivity of the membrane. Activating effect of H 2 S on the contractile properties of SMCs of the guinea pig ureter decreased by blocking ATP-dependent channels with glibenclamide. Analysis of the effect of H 2 S on sodium and calcium conductance of the membrane smooth muscles of the ureter using modified sodium-free and TEA- containing Krebs solution showed that the contribution of potassium conductance is mainly sold at high concentrations (100 and 1000 μmol) donor NaHS. Probably, that the impact of low concentrations of NaHS (10 μmol) on the amplitude of contractions SMCs of the ureter and performed through the activation of the calcium component of the action potential. It was shown, that activating effect of NaHS determined by involving sodium-dependent ion transporters to cAMP-dependent inhibition of potassium conductance membranes of smooth muscles.

Influence of the Cavity Length on the Behavior of Hybrid Fixed-Point Cells Constructed at INRIM

Hybrid cells with double carbon/carbon sheets are used at the Istituto Nazionale di Ricerca Metrologica (INRIM) for the realization of both pure metal fixed points and high-temperature metal–carbon eutectic points. Cells for the Cu and Co–C fixed points have been prepared to be used in the high-temperature fixed-point project of the Comite Consultatif de Thermometrie. The results of the evaluation processes were not completely satisfactory for the INRIM cells because of their low transition temperatures with respect to the best cells, and of a rather large melting range for the Co–C cell. A new design of the cells was devised, and considerable improvements were achieved with respect to the transition temperature, and the plateau shape and duration. As for the Cu point, the duration of the freezing plateaux increased by more than 50 % and the freezing temperature increased by 18 mK. As for the Co–C point, the melting temperature, expressed in terms of the point of inflection of the melting curve, increased by about 70 mK. The melting range of the plateaux, expressed as a difference \((T_{\mathrm{liquidus}} - T_{\mathrm{solid}})\) was reduced from about 180 mK to about 130 mK, with melting times \((t_{\mathrm{liquidus}} - t_{\mathrm{solid}})\) increased by about 50 %, as a consequence of an improvement of flatness and run-off of the plateaux.

Argon Triple-Point Device for Calibration of SPRTs

This paper presents an apparatus for the calibration of long-stem platinum resistance thermometers at the argon triple point $$(T_{90} = 83.8058\,\hbox {K})$$ , designed at the Institute of Low Temperature and Structural Research, Poland (INTiBS). A hermetically sealed cell filled at the Istituto Nazionale di Ricerca Metrologica, Italy with high purity gas (6N) is the main element of this apparatus. The cell is placed in a cryostat fully immersed in liquid nitrogen. A temperature-controlled shield ensures the quasi-adiabatic condition needed for proper realization of the phase transition. A system for correcting the temperature distribution along the thermometer well is also implemented. The cell cooling and argon solidification is carried out by filling the thermometer well with liquid nitrogen. A LabVIEW computer program written at INTiBS automatically controls the triple-point realization process. The duration of a melting plateau in the apparatus lasts for about 24 h. The melting width for $$F$$ between 20 % and 80 % was $${<}0.3$$ mK. The reproducibility of the plateau temperature is better than $${\pm }20\,\upmu \hbox {K}$$ .

Hand-use and tool-use in grasping control

The goal of this study was to elucidate the underlying mechanisms of hand and tool grasping control. We assumed that there is a single principle-governing grasping control irrespective of its effectors and that the degree of prior experience of the effector determines the smoothness of aperture control. Eight participants performed a reach-to-grasp task with four different effectors: index finger and thumb, middle finger and thumb, chopsticks, and a scissor-like tool. Although we employed different effectors with large mechanical variations and different degrees of prior use, maximum grip aperture was scaled as a function of object size and appeared at almost the same timing in all four types of grasping movements. Moreover, reaching time did not substantially differ among grasping conditions. However, plateau duration of the aperture profile differed by effector. Plateau duration was the longest in the unfamiliar scissor-like tool grasping condition. There was no difference between the unfamiliar hand-use grasp with the thumb and the middle finger and the familiar tool-grasp with chopsticks. The familiar hand-use grasp with the thumb and the index finger had the shortest plateau duration. These results supported the idea that there is an effector-independent continuity between hand-use and tool-use in motor control as a function of prior degree of use, rather than the conventionally assumed dichotomy between them.

Constraining properties of GRB magnetar central engines using the observed plateau luminosity and duration correlation

An intrinsic correlation has been identified between the luminosity and duration of plateaus in the X-ray afterglows of Gamma-Ray Bursts (GRBs; Dainotti et al. 2008), suggesting a central engine origin. The magnetar central engine model predicts an observable plateau phase, with plateau durations and luminosities being determined by the magnetic fields and spin periods of the newly formed magnetar. This paper analytically shows that the magnetar central engine model can explain, within the 1$\sigma$ uncertainties, the correlation between plateau luminosity and duration. The observed scatter in the correlation most likely originates in the spread of initial spin periods of the newly formed magnetar and provides an estimate of the maximum spin period of ~35 ms (assuming a constant mass, efficiency and beaming across the GRB sample). Additionally, by combining the observed data and simulations, we show that the magnetar emission is most likely narrowly beamed and has $\lesssim$20% efficiency in conversion of rotational energy from the magnetar into the observed plateau luminosity. The beaming angles and efficiencies obtained by this method are fully consistent with both predicted and observed values. We find that Short GRBs and Short GRBs with Extended Emission lie on the same correlation but are statistically inconsistent with being drawn from the same distribution as Long GRBs, this is consistent with them having a wider beaming angle than Long GRBs.

Self-similar relativistic blast waves with energy injection

A sufficiently powerful astrophysical source with power-law luminosity in time will give rise to a self-similar relativistic blast wave with a reverse shock travelling into the ejecta and a forward shock moving into the surrounding medium. Once energy injection ceases and the last energy is delivered to the shock front, the blast wave will transit into another self-similar stage depending only on the total amount of energy injected. I describe the effect of limited duration energy injection into environments with density depending on radius as a power law, emphasizing optical/X-ray Gamma-ray Burst afterglows as applications. The blast wave during injection is treated analytically, the transition following last energy injection with one-dimensional simulations. Flux equations for synchrotron emission from the forward and reverse shock regions are provided. The reverse shock emission can easily dominate, especially with different magnetizations for both regions. Reverse shock emission is shown to support both the reported X-ray and optical correlations between afterglow plateau duration and end time flux, independently of the luminosity power-law slope. The model is demonstrated by application to bursts 120521A and 090515, and can accommodate their steep post-plateau light-curve slopes.

A di/dt Feedback-Based Active Gate Driver for Smart Switching and Fast Overcurrent Protection of IGBT Modules

This paper presents an active gate driver (AGD) for IGBT modules to improve their overall performance under normal condition as well as fault condition. Specifically, during normal switching transients, a di/dt feedback controlled current source and current sink is introduced together with a push-pull buffer for dynamic gate current control. Compared to a conventional gate drive strategy, the proposed one has the capability of reducing the switching loss, delay time, and Miller plateau duration during turn-on and turn-off transient without sacrificing current and voltage stress. Under overcurrent condition, it provides a fast protection function for IGBT modules based on the evaluation of fault current level through the di/dt feedback signal. Moreover, the AGD features flexible protection modes, which overcomes the interruption of converter operation in the event of momentary short circuits. A step-down converter is built to evaluate the performance of the proposed driving schemes under various conditions, considering variation of turn-on/off gate resistance, current levels, and short-circuit fault types. Experimental results and detailed analysis are presented to verify the feasibility of the proposed approach.

Photometric and spectroscopic properties of Type II-P supernovae

We study a sample of 23 Type II Plateau supernovae (SNe II-P), all observed with the same set of instruments. Analysis of their photometric evolution confirms that their typical plateau duration is 100 days with little scatter, showing a tendency to get shorter for more energetic SNe. The rise time from explosion to plateau does not seem to correlate with luminosity. We analyze their spectra, measuring typical ejecta velocities, and confirm that they follow a well behaved power-law decline. We find indications of high-velocity material in the spectra of six of our SNe. We test different dust extinction correction methods by asking the following -- does the uniformity of the sample increase after the application of a given method? A reasonably behaved underlying distribution should become tighter after correction. No method we tested made a significant improvement.

The prompt–early afterglow connection in gamma-ray bursts: implications for the early afterglow physics

The early X-ray afterglow of gamma-ray bursts revealed by Swift carried many surprises. We focus in this paper on the plateau phase whose origin remains highly debated. We confront several newly discovered correlations between prompt and afterglow quantities (isotropic emitted energy in gamma-rays, luminosity and duration of the plateau) to several models proposed for the origin of plateaus in order to check if they can account for these observed correlations. We first show that the scenario of plateau formation by energy injection into the forward shock leads to an efficiency crisis for the prompt phase and therefore study two possible alternatives: the first one still takes place within the framework of the standard forward shock model but allows for a variation of the microphysics parameters to reduce the radiative efficiency at early times; in the second scenario the early afterglow results from a long-lived reverse shock. Its shape then depends on the distribution of energy as a function of Lorentz factor in the ejecta. In both cases, we first present simple analytical estimates of the plateau luminosity and duration and then compute detailed light curves. In the two considered scenarios we find that plateaus following the observed correlations can be obtained under the condition that specific additional ingredients are included. In the forward shock scenario, the preferred model supposes a wind external medium and a microphysics parameter epsilon_e that first varies as n^{-\nu} (n being the external density), with \nu~1 to get a flat plateau, before staying constant below a critical density n_0. To produce a plateau in the reverse shock scenario the ejecta must contain a tail of low Lorentz factor with a peak of energy deposition at \Gamma >~ 10.

Stochastic time analysis of syllable-referential intervals and simplex onsets

We pursue an analysis of the relation between qualitative syllable parses and their quantitative phonetic consequences. To do this, we express the statistics of a symbolic organization corresponding to a syllable parse in terms of continuous phonetic parameters which quantify the timing of the consonants and vowels that make up syllables: consonantal plateau durations, vowel durations, and their variances. These parameters can be estimated from continuous phonetic data. This enables analysis of the link between symbolic phonological form and the continuous phonetics in which this form is manifest. Pursuing such an analysis, we illustrate the predictions of the syllabic organization corresponding to simplex onsets and derive a number of previously experimentally observed and simulation results. Specifically, we derive not only the canonical phonetic manifestations of simplex onsets but also the result that, under certain conditions we make precise, the phonetic indices of the simplex onset organization change to a range of values characteristic of the complex onset organization. Finally, we explore the behavior of phonetic indices for syllabic organization over progressively increasing sizes of lexical samples, thereby concomitantly diversifying the phonetic context over which these indices are taken.

The Effect of the Rear Cavity Wall Ingot Shape on the Evolution of the Liquid–Solid Interface During Melting for the Eutectic Pt-C

When characterizing high-temperature fixed points, the fraction of the melting time of the regular part of the plateau with respect to the total melting time, is critical. Maximizing the melting duration minimizes the uncertainty associated with the determination of the fixed-point temperature. One factor that affects this quality is the effect of the thermal bridging between the external and internal surfaces of the ingot enclosed by the cell. This paper presents the results of simulations for the eutectic Pt-C, investigating the effects of different ingot shapes on the duration of the melt plateau. It was found that the formation of a thermal bridge from the rear of the blackbody cavity toward the outer surface of the ingot was critical and that its formation could be delayed or suppressed through a proper choice of the ingot shape. The shapes considered included, firstly, the shape of the rear of the cavity, in contact with the ingot, either cone-shaped or dome-shaped, and secondly, the inside rear surface of the cell, in contact with the ingot, being a cone, a convex dome, or flat. The presence of impurities in the alloy was taken into consideration, and its influence in the evolution of the liquid–solid interface compared with that for the pure alloy. The effect of changing the thermal isolation of the cell, at its front side, was also considered. A dome-shaped surface for the rear of the cavity was found to be more favorable for the development of a regular melting front, in conjunction with the segregation of impurities during melting. At the rear of the cell, a flat surface ensures the back wall is the last to experience thermal bridging, resulting in more extended melting plateaus.

Assessment of the effects of intramuscular administration of alfaxalone with and without medetomidine in Horsfield's tortoises (Agrionemys horsfieldii)

ObjectiveTo characterise four different intramuscular (IM) anaesthetic protocols, two with alfaxalone and two with alfaxalone in combination with medetomidine in terrestrial tortoises. Study designBlinded, randomized, cross‐over experimental study. AnimalsNine healthy adult male Horsfield's tortoises (Agrionemys horsfieldii). MethodsEach tortoise was randomly assigned to one of four different protocols: 1) 10 mg kg−1 alfaxalone; 2) 10 mg kg−1 alfaxalone + 0.10 mg kg−1 medetomidine; 3) 20 mg kg−1 alfaxalone; and 4) 20 mg kg−1 alfaxalone + 0.05 mg kg−1 medetomidine. During the experiment, the following variables were recorded: heart rate; respiratory rate; peripheral nociceptive responses; muscle strength; ability to intubate; palpebral, corneal and tap reflexes; and cloacal temperature. ResultsProtocols 1 and 2 resulted in moderate sedation with no analgesia, and moderate to deep sedation with minimal analgesia, respectively. Protocols 3 and 4 resulted in deep sedation or anaesthesia with variable analgesic effect; these two protocols had the longest total anaesthetic time and allowed intubation in 6/9 and 8/9 tortoises respectively. The total anaesthesia/sedation time produced by alfaxalone was significantly increased (p <0.05) by the addition of medetomidine. There were no significant differences regarding time to plateau phase and duration of plateau phase. Baseline heart rate of 53 ± 6 beats minute−1 decreased significantly (p <0.05) with all protocols, and was lower (p <0.05) in protocols 3 and 4. Heart rate increased after atipamezole administration, but the increase was transient. In two tortoises, extreme bradycardia with no cardiac activity for 10 minutes was observed with protocols 3 and 4. Conclusion and clinical relevanceAlfaxalone 10 and 20 mg kg−1 IM can be used for sedation for non‐painful procedures. Alfaxalone in combination with medetomidine can be used for deeper sedation or anaesthesia, but the observed respiratory and cardiovascular depression may limit its use.

An emerging coherent picture of red supergiant supernova explosions

Three lines of evidence indicate that in the most common type of core collapse supernovae, the energy deposited in the ejecta by the exploding core is approximately proportional to the progenitor mass cubed. This results stems from an observed uniformity of light curve plateau duration, a correlation between mass and ejecta velocity, and the known correlation between luminosity and velocity. This result ties in analytical and numerical models together with observations, providing us with clues as to the mechanism via which the explosion of the core deposits a small fraction of its energy into the hurled envelope.

DETERMINATION OF THE INTRINSIC LUMINOSITY TIME CORRELATION IN THE X-RAY AFTERGLOWS OF GAMMA-RAY BURSTS

Gamma-ray bursts (GRBs), which have been observed up to redshifts z approx 9.5 can be good probes of the early universe and have the potential of testing cosmological models. The analysis by Dainotti of GRB Swift afterglow lightcurves with known redshifts and definite X-ray plateau shows an anti-correlation between the rest frame time when the plateau ends (the plateau end time) and the calculated luminosity at that time (or approximately an anti-correlation between plateau duration and luminosity). We present here an update of this correlation with a larger data sample of 101 GRBs with good lightcurves. Since some of this correlation could result from the redshift dependences of these intrinsic parameters, namely their cosmological evolution we use the Efron-Petrosian method to reveal the intrinsic nature of this correlation. We find that a substantial part of the correlation is intrinsic and describe how we recover it and how this can be used to constrain physical models of the plateau emission, whose origin is still unknown. The present result could help clarifing the debated issue about the nature of the plateau emission.

SUPERNOVA EXPLOSIONS OF SUPER-ASYMPTOTIC GIANT BRANCH STARS: MULTICOLOR LIGHT CURVES OF ELECTRON-CAPTURE SUPERNOVAE

An electron-capture supernova (ECSN) is a core-collapse supernova (CCSN) explosion of a super-asymptotic giant branch (SAGB) star with a main-sequence mass $M_{\rm ms}\sim7-9.5M_\odot$. The explosion takes place in accordance with core bounce and subsequent neutrino heating and is a unique example successfully produced by first-principle simulations. This allows us to derive a first self-consistent multicolor light curves of a CCSN. Adopting the explosion properties derived by the first-principle simulation, i.e., the low explosion energy of $1.5\times10^{50}$ erg and the small $^{56}$Ni mass of $2.5\times10^{-3}M_\odot$, we perform a multigroup radiation hydrodynamics calculation of ECSNe and present multicolor light curves of ECSNe of SAGB stars with various envelope mass and hydrogen abundance. We demonstrate that a shock breakout has peak luminosity of $L\sim2\times10^{44}$ erg/s and can evaporate circumstellar dust up to $R\sim10^{17}$ cm for a case of carbon dust, that plateau luminosity and plateau duration of ECSNe are $L\sim10^{42}$ erg/s and $t\sim60-100$ days, respectively, and that a plateau is followed by a tail with a luminosity drop by $\sim4$ mag. The ECSN shows a bright and short plateau that is as bright as typical Type II plateau supernovae, and a faint tail that might be influenced by spin-down luminosity of a newborn pulsar. Furthermore, the theoretical models are compared with ECSN candidates: SN 1054 and SN 2008S. We find that SN 1054 shares the characteristics of the ECSNe. For SN 2008S, we find that its faint plateau requires an ECSN model with a significantly low explosion energy of $E\sim10^{48}$ erg.

SN 2009js AT THE CROSSROADS BETWEEN NORMAL AND SUBLUMINOUS TYPE IIP SUPERNOVAE: OPTICAL AND MID-INFRARED EVOLUTION

We present a study of SN 2009js in NGC 918. Multi-band Kanata optical photometry covering the first ~120 days show the source to be a Type IIP SN. Reddening is dominated by that due to our Galaxy. One-year-post-explosion photometry with the NTT, and a Subaru optical spectrum 16 days post-discovery, both imply a good match with the well-studied subluminous SN 2005cs. The plateau phase luminosity of SN 2009js and its plateau duration are more similar to the intermediate luminosity IIP SN 2008in. Thus, SN 2009js shares characteristics with both subluminous and intermediate luminosity SNe. Its radioactive tail luminosity lies between SN 2005cs and SN 2008in, whereas its quasi-bolometric luminosity decline from peak to plateau (quantified by a newly-defined parameter Delta[logL] measuring adiabatic cooling following shock breakout) is much smaller than both the others. We estimate the ejected mass of 56Ni to be low (~0.007 Msun). The SN explosion energy appears to have been small, similar to SN 2005cs. SN 2009js is the first subluminous SN IIP to be studied in the mid-infrared. It was serendipitously caught by Spitzer at very early times. In addition, it was detected by WISE 105 days later with a significant 4.6 micron flux excess above the photosphere. The infrared excess luminosity relative to the photosphere is clearly smaller than that of SN 2004dj extensively studied in the mid-infrared. The excess may be tentatively assigned to heated dust with mass ~3e-5 Msun, or to CO fundamental emission as a precursor to dust formation.

Calcium dynamics during NMDA‐induced membrane potential oscillations in lamprey spinal neurons – contribution of L‐type calcium channels (CaV1.3)

NMDA receptor-dependent, intrinsic membrane potential oscillations are an important element in the operation of the lamprey locomotor network. They involve a cyclic influx of calcium, leading to an activation of calcium-activated potassium (KCa) channels that in turn contributes to the termination of the depolarized plateau and membrane repolarization. In this study, we have investigated the calcium dynamics in different regions of lamprey spinal neurons during membrane potential oscillations, using confocal calcium imaging in combination with intracellular recordings. Calcium fluctuations were observed in both soma and dendrites, timed to the oscillations. The calcium level increased sharply at the onset of membrane depolarization, to reach its maximum by the end of the plateau. The calcium peak in distal dendrites typically occurred earlier than in the soma during the oscillatory cycle. The L-type calcium channel blocker nimodipine increased the duration of the depolarized plateau phase in most cells tested, whereas the agonist Bay K 8644 decreased plateau duration. Bay K 8644 increased the amplitude of calcium fluctuations, particularly in distal dendrites, whereas nimodipine caused a decrease, suggesting that L-type low-voltage-activated calcium channels are mainly localized in these regions. Our results thus indicate that dendritic CaV1.3-like calcium channels are activated during NMDA-mediated membrane potential oscillations. This calcium influx activates KCa channels involved in plateau termination.

Bacillus anthracis Protective Antigen Kinetics in Inhalation Spore-Challenged Untreated or Levofloxacin/ Raxibacumab-Treated New Zealand White Rabbits

Inhaled Bacillus anthracis spores germinate and the subsequent vegetative growth results in bacteremia and toxin production. Anthrax toxin is tripartite: the lethal factor and edema factor are enzymatic moieties, while the protective antigen (PA) binds to cell receptors and the enzymatic moieties. Antibiotics can control B. anthracis bacteremia, whereas raxibacumab binds PA and blocks lethal toxin effects. This study assessed plasma PA kinetics in rabbits following an inhaled B. anthracis spore challenge. Additionally, at 84 h post-challenge, 42% of challenged rabbits that had survived were treated with either levofloxacin/placebo or levofloxacin/raxibacumab. The profiles were modeled using a modified Gompertz/second exponential growth phase model in untreated rabbits, with added monoexponential PA elimination in treated rabbits. Shorter survival times were related to a higher plateau and a faster increase in PA levels. PA elimination half-lives were 10 and 19 h for the levofloxacin/placebo and levofloxacin/raxibacumab groups, respectively, with the difference attributable to persistent circulating PA-raxibacumab complex. PA kinetics were similar between untreated and treated rabbits, with one exception: treated rabbits had a plateau phase nearly twice as long as that for untreated rabbits. Treated rabbits that succumbed to disease had higher plateau PA levels and shorter plateau duration than surviving treated rabbits.