Background: Regional anesthesia has gained wider popularity over general anesthesia, especially the combination of hayluronidase with local anesthesia in different ophthalmic surgeries aids to increase safety of procedure, less distortion of surgical site, decrease incidence of post-operative strabismus, and limits local anesthetic myotoxicty because of quicker spread. Objective: Studying the effect of hayluronidase as an adjuvant to local anesthesia of the eye on the intra-ocular pressure and its effect on duration of local anesthesia. Patients and Methods: A prospective randomized study was carried out on 40 patients divided into 2 equal groups; group A received local anesthesia without hayaloronidase, while group B received local anesthesia with hayaloronidase. Results: The duration of sensory block in group A was 67.5 min, and in group B was 90 min. The IOP in group A was 27.5 mm Hg, and in group B was 21.5 mm Hg. Conclusion: Combination of hayaloronidase with the local anesthesia mixture helped to decrease the intraocular pressure, thus made the operation easier with less complications, and helped to prolong the post-operative analgesia.