Annotation. The aim of the study is to improve the treatment outcomes of patients with duodenal fistulas. The object of retro- and prospective study were 14 patients with external unformed high-flow duodenal fistulas, who were treated in the Shalimov National Institute of Surgery and Transplantology during 2016–2019. All patients were performed a complex examination, which included general clinical, laboratory, instrumental and statistical research methods. We have developed and patented a minimally invasive method of treatment of duodenal fistulas, which involves endoscopic placement of a nitinol-coated self-healing stent in the area of the defect and VAC therapy from the outer opening of the fistula. Statistical processing of research results was performed using spreadsheets Microsoft® Office Excel (2017) and statistical processing program Statgraphics Professional 16.0.03. Student's test and Wilcoxon-Mann-Whitney test were used. The use of the developed method of treatment allowed reducing the number of postoperative complications by 32%, to reduce the duration of treatment (from 41,16±5,14 to 27,2±4,7 days, p>0.05). The overall mortality in the experimental group decreased by 43% compared with the mortality of the comparison group. Our proposed minimally invasive method of treatment of duodenal fistulas helps to improve the results of treatment of patients, namely to reduce the duration of treatment and reduce the number of complications and mortality rate.