Dual Gold Research Articles

Computational Understanding of Dual Gold and Photoredox-Catalyzed Regioselective Thiosulfonylation of Alkenes.

Herein, a computational work was carried out to gain mechanistic insights into dual gold and photoredox-catalyzed regioselective thiosulfonylation of alkenes with PhSO2SCF3. Computational results suggest that it is more favorable for the complex of Au(I) with PhSO2SCF3 (INT1), instead of an Au(I) catalyst or individual substrates, to quench the excited *[Ru]II photocatalyst in a single-electron oxidative manner to afford [Ru]III. The complexation of the Au(I) catalyst with PhSO2SCF3 could lead to a substantially lowered energy level of the lowest unoccupied molecular orbital, which may be mainly responsible for the feasibility of INT1 in quenching the excited photocatalyst. The resultant single-electron reduced complex, subsequently, is ready to undergo a S-S bond cleavage to form an Au(I)-SCF3 species and a benzenesulfonyl radical. Next, the yielded Au(I)-SCF3 species could undergo single-electron oxidation by [Ru]III to afford an Au(II) intermediate. Subsequently, the binding with an alkyl radical for the formed Au(II) species could occur to further convert to an Au(III) species, from which the final product can be furnished by a reductive elimination step and the Au(I) catalyst is regenerated. Thus, an Au(I)/Au(II)/Au(III)/Au(I) catalytic cycle is suggested to mainly account for the regioselective thiosulfonylation of alkenes.

Ефективність застосування гербіцидів в розсаднику при вирощуванні саджанців плодових культур

The results of research on the effectiveness of the use of soil and contact herbicides when growing one-year seedlings in the second field of the nursery are presented. When growing apple seedlings, a positive result was obtained on average over the years of research with the application of soil pesticides Lumax and Zenkor, especially with additional application during the growing season of contact – Fusilada or Targa super. In some years, a good result was also obtained when Stomp and Devrinol were applied, while in others, the suppression of planting material was noted. Practically similar results were obtained when they were introduced in the process of growing plum seedlings. It is also worth noting Lumax, when applying which the diameter of the stem (by 2-6 mm), the height of the seedlings (by 40-60 cm) were greater than in other options with the optimal number of side branches (4-6 pcs.) and their average length (40-80 cm). Plum seedlings were depressed when Devrinol, Zenkor and Gezagard were applied, and in a separate year, Stompa and Dual Gold. In studies with cherry seedlings, they had active growth when applying soil herbicides Gezagard and Zenkor, as well as when combining the former with contact Fuzilad and Targa Super. Seedlings were significantly suppressed when applying other studied herbicides, especially Dual Gold, both alone and in combination with contact herbicides, while the number of branched seedlings decreased. Most herbicides did not have a negative effect on the biometric indicators of cherry seedlings. slight inhibition of growth and the number of side branches was noted when Stomp and Dual Gold were applied. In advance, it is possible to highlight the application of Devrinol, Zencor and Lumax separately without combining with the application of contact herbicides. Key words: seedlings, apple, plum, cherry, sweet cherry, soil herbicides, contact herbicides, biometric indicators.

Mechanistic understanding of the dual gold and photoredox-catalyzed thiosulfonylation of alkynes and enynes: a DFT study

The detailed mechanisms of dual gold and photoredox-catalyzed thiosulfonylation of alkynes and 1,6-enynes with PhSO2SCF3 were explored via DFT calculations.

Tumor identification via in vivo portable Raman detection of sialic acid with a dual gold nanoprobe system.

A dual gold nanoprobe system was designed for in vivo portable Raman detection of sialic acid (SA) for tumor identification. The dual gold nanoprobe system contained two gold nanoprobes, Au10-DTTC/PEG-PBA and Au40-PEG-SA. Au10-DTTC/PEG-PBA was constructed on a 10 nm gold nanoparticle modified with 3,3'-diethylthia tricarbocyanine iodide (DTTCI) as the Raman reporter and 3-aminophenylboronic acid (APBA) through a thiol PEG succinimidyl carboxymethyl ester (HS-PEG-NHS) linker for specific recognition of SA. Au40-PEG-SA was constructed on a 40 nm gold nanoparticle modified with SA through HS-PEG-NHS. For in vivo detection of SA, Au10-DTTC/PEG-PBA and Au40-PEG-SA were subsequently injected into tumor xenografted mice with optimal interval and retention times. Through the specific recognition between PBA and SA, the conjugates of Au10-DTTC/PEG-PBA and Au40-PEG-SA formed in the tumor region emitted strong SERS signals of DTTC, which could be detected by a portable Raman detector. This work provides a convenient and portable method to detect SA in tumor xenografted mice, which is useful for family-stay identification and clinical cleavage of tumors.

О применении гербицидов напосевах столовой свеклы

Under Shirak region conditions on table beet’s sowing herbicides Dual Gold and Zellek Super in 1,5 and 1 l/ha dosages have been tested. They showed high biological efficacy against certain groups of weeds and increased the crop, which was more in the version with Dual Gold. No residues of them in crop have been detected. It was not revealed essential deviation of contents of main biochemical indices of root - crops from check.

Prediction of acute poisoning in agricultural workers during using pesticides on berry and melon crops

acute pesticide poisoning is a global health problem. According to the WHO, poisoningby chemicals, including chemical plant protection products, is a leading non-communicable disease.Violation of the rules for working with pesticides leads to the occurrence of occupational diseasesamong workers. Therefore, compliance with pesticide regulations and the use of personal protective
 equipment is a very important preventive measure. The purpose of our work: to predict the occur-rence of acute toxic effects in workers who treat berry and melon crops with pesticides. Research
 materials and methods: to assess the probability of acute toxic effects among workers who deal withactive substances and preparations based on them. We calculated three indicators: the coefficient of
 possible inhalation poisoning (DSanPiN 8.8.1.002-98), the selectivity of pesticides by inhalation pes-ticides and the selectivity of pesticides under dermal exposure according to the method of Sergeeva
 S.G. Results: according to the “Hygienic classification of pesticides by degree of danger” DSanPiN8.8.1.002-98 all tested active substances belong to the 4th class of danger according to the coefficientof possible inhalation poisoning, which was less than 0,5. The coefficient of selectivity of the actionof pesticides during inhalation exposure to active substances was in the range of 7,41 – 1000,0.
 For cyprodinil, phenhexamid, azoxystrobin, pyraclostrobin, copper chloride, pendimethalin, S-me-tolachlor, glyphosate, and abamectin, it was less than 100, indicating their relatively low selectivity
 of action. Other studied active substances had a high selectivity of action, since this coefficient was
 more than 100. It was established that all studied drugs have sufficient selectivity of action when in-haled. The coefficient of selectivity for dermal exposure was more than 100 for all the studied active
 substances, except for S-metolachlor and glyphosate. Preparations Trinol, VG, Signum, VG, RidomilGold R 161 WG, VG, Stomp Aqua, SK, Dual Gold 960 EC, KE, Herbolex v.r. have low selectivityof action when entering through the skin, all other pesticides have sufficient selectivity of action. Theobtained data indicate that all the active substances under study are not dangerous (hazard class 4),according to DSanPiN 8.8.1.002-98. Therefore, when working with these substances you need tofollow hygienic regulations.

Dual ligand-capped gold nanoclusters for the smart detection of specific reactive oxygen species.

Quantitative detection of different types of reactive oxygen species (ROS) is vital for understanding the crucial roles of them in biological processes. However, few researches achieved the detection of multiple types of ROS with one probe until now. Given this, we designed and prepared fluorescent gold nanoclusters capped by dual ligand bovine serum albumin and lysozyme (BSA-LYS-AuNCs), which could detect 3 specific types of ROS based on its different fluorescent responses to H2O2, •OH and ClO-, respectively. The limit of detection (LOD) of H2O2, •OH, and ClO- was as low as 0.82μM, 0.45μM, and 0.62μM. Moreover, as an important ROS type, ClO- was detected with high sensitivity and low LOD by BSA-LYS-AuNCs. It was also proved that the crosslinking of protein mainly contributed to the unique fluorescent characteristics of the probe exposing to ClO-. Furthermore, the fluorescent probe achieved the smart detection of hROS (including •OH and ClO-) and wROS (the form of H2O2) in the real sample, which could also been applied specifically to the detection of antioxidants, e.g. ascorbic acid. The gold nanoclusters developedhavehighpotential for the smart detection of multiple ROS in the body fluid of organisms.

CONTROL OF CORN POLLUTION IN THE CONDITIONS OF THE RIGHT-BANK FOREST STEPPE

This article presents the results of studies of the main elements and methods of controlling the development of weeds in corn crops and the identified changes in water and nutrient properties of the soil. The optimal tank mixtures and technological combinations of new soil and insurance herbicides have been determined, which provide a high level of technical efficiency on a wide species spectrum of weeds that clog corn crops. In particular, for farm conditions, the complex nature of the formation of the type of weediness, which changes during the growing season of the crop, was noted. The results of assessments of the dynamics of weed vegetation indicate a gradual increase in cenotic tension due to the gradual transition of dominant species of weeds, such as Chenopodium album L., Amaranthus retroflexus L., Echinochloa crus-galli L., Elytrigia repens (L.) Gould , Sonchus arvensis L, Cirsium arvense L., Convolvulus arvensis L. in the middle tier of sowing with a simultaneous increase in the frequency of their determination by 1.1-1.3 times. It was established that the best growth and development of the total leaf surface of corn plants (2.15-2.26 pcs./m2) was noted on the herbicide agro background and complete removal of weeds, and with natural weediness of the crops - a negative effect on growth processes, size and duration of functioning of leaves (1.14 pcs./m2). According to the research results, the technical efficiency against weeds of the first wave reached 100% when combining soil and insurance herbicides - Dual Gold - 1.5 l/ha (before sowing) + Stellar - 1.25 l/ha + Surfactant Metolate - 1.25 l/ha (by stairs); during the second and subsequent waves of weeds, protection systems that combine vegetative and soil deterrent effects are best controlled (Stellar - 0.8 l/ha + Akris - 1.5 l/ha + Surfactant Metolate - 0.8 l/ha and Kelvin Plus - 0.3 kg/ha + Akris - 1.5 l/ha + PA Hasten - 1 l/ha). The highest yield of corn grain (6.98 t ha-1 and 6.81 t ha-1) was obtained from the combination of soil and insurance preparations Akris (before sowing) + Kelvin Plus and PAR Hasten (after the steps) and Dual Gold (before sowing) + Stellar and surfactant Metolat (by stairs); Akris + Stellar + metolat surfactant (yield - 6.68 t ha-1) was singled out among post-emergence herbicide mixtures; with autonomous use of the preparations Stellar and Kelvin Plus, the yield was 6.35 t ha-1 and 6.22 t ha-1, respectively. The identical economic expediency of using such variants of herbicide application on corn Akris, 1.5 l/ha + Stellar, 0.8 l/ha + Metolat surfactant, 0.8 l/ha and Stellar, 1.25 l/ha + Metolat surfactant, has been confirmed ,1.25 l/ha, which was 43% higher than in the control with natural weeding and 33.2-33.4% higher than in the option of inter-row cultivation with manual weeding.

The influence of herbicides and their combination on the development and yield in maize hybrid Knezha 613

In 2018 and 2019 an experiment was conducted using the block method with 12 herbicides in the experimental field of the Maize Research Institute – Knezha. The studies were performed with a maize hybrid Knezha 613 – group 500-600 by FAO, cultivated without irrigation. We studied 8 systems of herbicides which included 6 soil preparations: Adengo 465 SK (isoxaflutole) at a dose of 350 ml/ha; Merlin Flex 480 SK (isoxaflutole) at a dose of 420 ml/ha; Spectrum (dimetenamid – P) at a dose of 1400 ml/ha; Gardoprim plus gold (S-metolachlor + terbutilazin) at a dose of 4500 ml/ha; Dual Gold 960 EK (S-metolachlor) at a dose of 1500 ml/ha and Stomp NEW 330 EK (pendimetalin) at a dose of 4000 ml/ha. The studies included foliar preparations, applied in a phase fourth-fifths leaf of the crop, after the soil ones: Elumis OD (nicoslfuron + mesotrion) at a dose of 2000 ml/ha; Aminopielik 600 SL (2,4-D amine salt) at a dose of 1200 ml/ha; Lumax (S-metolachlor + terbutilazin + mesotrion) at a dose 3000 ml/ha; Matоn 600 EK (2,4-D ester) at a dose of 1100 ml/ha; Laudis OD (tembotrione) at a dose of 2000 ml/ha. Under the test conditions, the herbicidal system Dual gold 960 EK at a dose of 1500 ml/ha and Elumis OD et a dose of 2000 ml/ha is the most efficient: destroying 94.8% (2018) and 94.4 (2019) of the common weeds.

Cover Feature: Heterobimetallic Gold/Ruthenium Complexes Synthesized via Post‐functionalization and Applied in Dual Photoredox Gold Catalysis (Chem. Eur. J. 57/2022)

Enjoying the sun: The cover illustrates the potential of heterobimetallic AuI/RuII complexes to facilitate the P arylation of H-phosphonates with diazonium salts, while visible light kicks off the dual gold and photoredox catalytic cycle. The underlying structure of the catalysts’ coordinating ligand system is accessible by a novel postfunctionalization approach, and the stereochemistry can be controlled by the order of metal coordination and click reaction. More information can be found in the Research Article by F. Breher and co-workers (DOI: 10.1002/chem.202201856).

Efficacy of herbicides, herbicide combinations and herbicide tank mixtures on lentil (Lens culinaris Medik.)

Abstract. The research was conducted during 2019 - 2021 on pellic vertisol soil type. Under investigation was lentil cultivar Ilina (Lens culinaris Medik.). A total of 23 variants were investigated: untreated control, 8 herbicides – Pendistar 40 SC (pendimethalin), Dual gold 960 EC (S-metolachlor), Lentagran VP (pyridate), Challenge 600 SC (aclonifen), Zencor 600 SC (metribuzin), Wish top (quizalofop-P-ethyl), Zetrola (propaquizafop) and Passat 40 (imazamox), as well as combinations and tank mixtures between them. Soil-applied herbicides were used during the period after sowing before emergence. Foliar-applied herbicides were used during 2-3, 4-5 or 6-7 real leaf stage of the lentil. All of the herbicides, herbicide combinations and herbicide tank-mixtures were applied in a working solution of 300 l/ha. Mixing of foliar-applied herbicides was done in the tank on the sprayer. The combinations of herbicide Lentagran with soil-applied herbicides Pendistar and Dual gold, as well as herbicides Challenge with foliar-applied herbicides Wish top and Zetrola had an additive effect on herbicide efficacy. The herbicides Lentagran and Zencor, as well as their combinations, successfully controlled Clearfield and ExpressSun sunflower self-sown plants in lentil crops. The foliar-applied herbicide Passat controlled all annual and perennial broadleaved and graminaceous weeds and self-sown plants. The use of foliar-applied herbicide Passat and soil-applied herbicide Zencor at a dose of 900 g/ha led to high phytotoxicity in lentil plants – rate 3 according to the scale of EWRS. Double use of Zencor at doses of 600 + 300 g/ha and the combined use of the herbicides Challenge and Zetrola led to low phytotoxicity in lentil – rate 2 according to the scale of EWRS. The highest yields of lentil seeds were obtained by use of herbicide combinations Pendistar 5 l/ha + Lentagran 500 + 500 ml/ha and Pendistar 5 l/ha + Lentagran 1 l/ha. High yields were also obtained when combining Challenge 3 + 1 l/ha with Wish top 1.25 l/ha, as well as by the herbicide combination Challenge 4 l/ha + Wish top 1.25 l/ha.

Regio‐ and Stereoselective Synthesis of Ynenamides through Gold(I)‐Catalyzed Hydroalkynylation of Ynamides

AbstractTransition metal catalysis is a useful tool for C−C bond‐forming reactions. Of special interest is the hydroalkynylation reaction of alkynes, which provides a simple method for the synthesis of enynes representing interesting structural motifs in organic chemistry. So far, there are only a few examples of gold(I)‐catalyzed hydroalkynylation reactions. Herein, we were able to show experimentally that the gold(I)‐catalyzed hydroalkynylation of ynamides leads regio‐ and stereoselectively to the corresponding ynenamides, a rather unknown type of molecule. A wide range of products could be generated with yields up to 90 % and, in contrast to many other gold‐catalyzed alkyne dimerization reactions, alkyl groups are tolerated. Quantum chemical calculations and NMR labelling experiments reveal a mechanism via dual gold catalysis.

Peculiarities of herbicide use on oil flax in different soil and climatic conditions of the Western Ciscaucasia

The article presents the research results on the effect of pre-emergence and foliar herbicide treatments on the oil flax productivity in soil and climatic conditions of unstable and insufficient moistening zones of the Western Ciscaucasia. The pre-emergence application of herbicides Frontier Optima, EC (1.2 l/ha) or Dual Gold, EC (1.6 l/ha) on leached chernozem in the zone of unstable moistening led to an increase in the oil flax yield which exceeds the control with the manual weeding by 0.09 t/ha. The additional foliar treatment of sowings with Tifi, WDG (0.025 kg/ha) decreased the crop yield by 0.29 and 0.23 t/ha, respectively. The highest increase in yield (0.07 t/ha) on leached chernozem in the zone of insufficient moistening was achieved with the pre-emergence application of herbicide Dual Gold, EC (1.6 l/ha).

Гербициды почвенного действия в системе защиты масличного льна от сорняков на юге России

Since there are no pre-emergence herbicides in “The State Catalogue of pesticides and agrochemicals” approved for use in the Russian Federation on oil flax, in 2018–2020, we studied the pre-emergence herbicides on crop sowings in the zone of unstable moistening on leached chernozem (VNIIMK, Kras-nodar) and in the zone of insufficient moistening on ordinary chernozem (Don experimental station of VNIIMK, Rostov region). We observed the decrease in weed infestation in oil flax sowings when we ap-plied pre-emergence herbicides. The highest biological effectiveness was observed in the zone of unstable moistening, when the plants were sprayed with Tifi, WDG (0.025 kg/ha) at the stage of true leaves development of flax on the background of pre-emergence application with Frontier Optima, EC (1.2 l/ha) – 63.2%; in the zone of insufficient moistening – at pre-emergence application with the tank mixture Dual Gold, EC (1.6 l/ha) + Gezagard, SC (3.5 l/ha) – 67.8%. However, we recorded the phytotoxic effect on oil flax at application of the tank mixture Dual Gold, EC (1.6 l/ha) + Gezagard, SC (3.5 l/ha) in the amount of 23.7–35.7% on the EWRC scale (Europe-an Weed Research Council). We established the positive effect of pre-emergence soil herbicides Frontier Optima, EC (1.2 l/ha) and Dual Gold, EC (1.6 l/ha) on the oil flax seed yield and economic indicators of its production. Herbicides Frontier Optima, EC (1.2 l/ha) and Dual Gold, EC (1.6 l/ha) are recommended for inclusion into the list of preparations approved for use on oil flax in the Russian Federation. Crop foliar treatment with herbicide Tifi, WDG (0.025 kg/ha) on the background of pre-emergence application of the preparation Frontier Optima, EC (1.2 l/ha) or Dual Gold, EC (1.6 l/ha) in the zone of unstable moistening led to yield decrease by 0.29 and 0.23 t/ha, respec-tively, it did not affect the oil flax yield in the zone of insufficient moistening.

Author Correction: Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis

Author Correction: Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis

Efficacy of Herbicides, Herbicide Tank Mixtures and Herbicide Combinations on Express Sun Oil-Bearing Sunflower (Helianthus Annuus L.)

During the period 2018-2020 a field experiment has been carried out with the oil-bearing sunflower hybrid P64LЕ121 (Helianthus annuus L.). It is a sulfo tolerant hybrid by ExpressSun technology. A total of 25 variants were investigated. They included untreated control, 2 herbicides applied alone in addition with adjuvant Trend 90, 10 herbicide tank mixtures and 10 herbicide combinations. Soil-applied combined herbicides were performed during after sowing before emergence period of the sunflower. Foliar-applied herbicides were performed during 3-4 leaf sunflower stage. Full control of annual broadleaved weeds in ExpressSun oil-bearing is provided by a single treatment with herbicide Fluence at a dose of 40 g/ha or with herbicide Evorelle express at a dose of 60 g/ha applied during 3-4 leaf sunflower stage. Full controls of perennial broadleaved weeds is provided by two treatments with herbicide Fluence in doses of 20+20 g/ha or with herbicide Evorelle express in doses of 30+30 g/ha, applied during 3-4 leaf and 7-8 leaf sunflower stages. In the presence of annual and perennial broadleaved and graminaceous weeds, it is necessary to apply Fluence and Evorelle express as herbicide tank mixtures together with foliar-applied antigraminaceous herbicides Fusilade forte, Stratos ultra or Targa max. In the absence of perennial graminaceous weeds, it is necessary to apply herbicides Fluence and Evorelle express as herbicide combinations with soil-applied antigraminaceous herbicides Dual gold or Indipen. The highest seed yield is obtained by herbicide tank mixture Fluence + Fusilade forte, followed by herbicide tank mixture Evorelle express + Stratos ultra. High seed yields are also obtained by use of herbicide combinations Indipen + Evorelle express and Dual gold + Fluence.

A ratio fluorescence method based on dual emissive gold nanoclusters for detection of biomolecules and metal ions.

Gold nanoclusters have good biocompatibility and can be easily modified to improve their luminescence properties. In this study, we prepared a new type of dual-emitting gold nanoclusters (d-Au NCs) for discriminative detection of phenylalanine and Fe3+ with high selectivity and sensitivity. The fluorescence sensor which was synthesized without any further assembly or conjugation shows dual-emissions at 430 nm and 600 nm under a single excitation at 350 nm. Phenylalanine can turn on the red emission of the probe, while Fe3+ can turn on its yellow emission and turn off the red emission. By detecting a variety of amino acids and metal ions, d-Au NCs showed good selectivity to phenylalanine and Fe3+. Finally, this method was applied to determine phenylalanine and Fe3+ in lake water, human urine and milk, which has certain application prospects in the field of biology and environment.

Optimization of the elements of onion production technology in an annual crop in the conditions of central Russia

The object of research is onion, cultivated as an annual crop in the Nonchernozem zone of the Russian Federation. The aim of the research is to develop an improved technology for the production of bulb in an annual crop, providing a yield of 70-80 t/ha on alluvial meadow soils of the Nonchernozem zone. Research method - field test. It has been established that the probability of performing each technological operation should be at least 95%. Sowing the seeds, which are previously cleansed from the rot, must be done at an earlier date. The required yield was achieved at N 200 P 160 K 280 + Humic chemical "Rostok" + 10 l/ha BisolbiSan, Azotovit, Phosphatovit biopreparations in equal proportions. The use of the microbiological preparation BisolbiSan in 1% concentration with chemical two-component fungicides (excluding copper-containing ones) increases the immunity of onion plants. In conditions of warm, humid summer, fungicidal treatments of onions are optimal at intervals of 7-10 days from the third decade of June to the end of July. The maximum weed suppression is provided by the post-sowing application of the Stomp Professional + Dual Gold tank mix (3 + 1 l/ha) in combination with the subsequent pre-emergence treatment with Reglon Forte (2 l/ha) and the post-emergence Goal 2E (0.5 l/ha).

Unveiling the complexity of the dual gold(I) catalyzed intermolecular hydroamination of alkynes leading to vinylazoles

The conversion of alkynes into functionalised alkenes catalyzed by Au(NHC) complexes (NHC = N-heterocyclic carbene) is a fundamental and atom-economical transformation yet its mechanistic understanding is limited. In order to shed light on such catalytic reaction mechanisms, computational tools are utilized to gain insights into the gold catalyzed intermolecular hydroamination of internal alkynes. The combination of alkynes and benzotriazole leads to vinylazoles via a solvent free, gold(I) mediated hydroamination. DFT permits an in-depth discussion of single versus dual metal catalysis in this transformation. The role of the triflate anion is studied, being essential for the protodeauration and it helped to clarify the rate determining step, that consists of the gold-tiazolyl nucleophilic attack to the gold-alkyne π-complex.

The EFFICACY OF DUAL GOLD (S-METOLACHLOR) ON WEED BIOMASS (g m-2) AND ON THE GROWTH AND YIELD COMPONENTS OF SUGAR BEET (BETA VULGARIS L.) CV. CALIFORNIA-KWS

Weed infestation is a major problem and matter of concern as it reduces yield as well as quality of many crops including sugar beet. Manual weeding is very tedious, costly, time consuming and most probably non-availability of trained and skillful labor is another issue. Keeping in view these facts, an experiment was performed to evaluate the efficacy of dual gold on the weed biomass (gm-2) and on the growth and yield components of sugar beet (Beta vulgaris L.) cv. California-KWS during 2013-14 and 2014-15. The study was performed using RCBD having five treatments and three replications. The treatments included different application times (pre-emergence application and application after 15, 30 and 45 days after emergence) of dual gold (s-Metolachlor) and a control (weedy check). Data were recorded on fresh and dry weed biomasses (g m-2), number of leaves plant-1, leaf area plant-1 (cm2), leaf and root weights plant-1 (g), sucrose%, TSS%, root and sugar yields (t ha-1). The results showed significant variation among the treatments for all parameters during both years of study. Among the treatments the dual gold (s-Metolachlor) applied as pre-emergence reduced weed fresh and dry biomasses (g m-2) and also enhanced number of leaves plant-1, leaf area (cm2), leaf and root weight plant-1, sucrose%, TSS%, root and sugar yields (t ha-1) during both years. Hence it is concluded that dual gold (s-Metolachlor) applied as pre-emergence is best for eradicating weeds at early stages of growth and hence improving yield and quality of sugar beet under Dera Ismail Khan Conditions.