ObjectivesThe aim of this study was to perform an experimental evaluation of the synergistic effects of laser-texturing and different traditional surface modification approaches to improve the adhesion of glass fiber-reinforced composite (GFRC) posts to resin-matrix cements used in endodontically treated teeth rehabilitation. MethodsOne hundred and ten freshly extracted mandibular single-rooted premolars were endodontically treated and groups of specimens were divided according to the GFRC cementation after different surface treatment, as follow (n = 10): silane-based conditioning (SIL); 9.7 % HF acid-etching (HF); 35 % H2O2 etching (H2O2); grit-blasting (GB); HF plus H2O2 etching (HFH2O2); 6 W Nd:YAG laser-texturing (L6W); 4.5 W Nd:YAG laser-texturing (L4.5W); 3 W Nd:YAG laser-texturing (L3W); 3 W Nd:YAG plus 35 % H2O2 (L3WH2O2); 3 W Nd:YAG plus SIL (L3WSIL); and untreated (C). GFRC posts were cemented into the tooth root canals using a dual-cured resin cement. Then, specimens were cross-sectioned and mechanically assessed by push-out bond strength tests. Specimens were inspected by optical microscopy and scanning electron microscopy (SEM) at magnification from × 30 up to × 2000. The failure mode was recorded by microscopic analyses after the bond strenght tests. ResultsSurface analyses of the GFRC posts showed a rough and retentive morphological aspect with a removal of the outer epoxy matrix layer and exposure of glass fibers after laser-texturing, grit-blasting, or etching under 35 % H2O2. The highest bond strength values at 21.8 MPa was recorded for GFRC posts after laser-texturing on 3W plus silane-based conditioning followed by the group etched with 35 % H2O2 (20.5 MPa). The failure mode was microscopically characterized as cohesive and mixed pathways. The lowest bond strength values around 5 and 9 MPa and adhesive failure were recorded for the untreated GFRC group or specimens etched with HF. ConclusionsThe combination of acidic etching and silane conditioning with laser-texturing at moderate intensity promoted an adequate surface modification of GFRC posts and increased adhesion to a resin-matrix cement. Such combination of physicochemical approaches can enhance the long-term mechanical behavior of the restorative interface at endodontically treated teeth. Clinical relevanceCombining traditional and novel physicochemical approaches can provide promising adhesion pathways for glass fiber-reinforced composite posts to resin-matrix cements. A high mechanical interlocking of the resin-matrix cements and the stable retention of the teeth root intracanal posts can decrease the risks of clinical failures by fracture and detachment of the intraradicular interface.