This article explores the utilization potential of three distinct mine tailings (MT) viz.; red mud (RM), iron tailings (FeT), and zinc tailings (ZT) as geopolymer binders to stabilize the soil for road subgrade application. The strength and durability of soil treated with various MT-based geopolymers are examined through a succession of unconfined compressive strength (UCS), California bearing ratio (CBR) and alternate wetting-drying tests respectively. Furthermore, permeability tests are also conducted to examine the hydraulic response of soil amended with MT-based geopolymers. Finally, leaching study is performed to examine the geo-environmental implications of various geopolymer specimens. The experimental results reveal that the UCS of untreated soil is increased from 0.39 MPa to 5.24 MPa, 5.13 MPa and 3.78 MPa with the use of RM, FeT, and ZT-based geopolymers respectively. The study further shows a 26-fold, 19-fold, and 15.8-fold increase in the soaked CBR values of soil when it is stabilized with RM, FeT, and ZT-based geopolymers respectively. In contrast to untreated soil, soil stabilized with MT-based geopolymers exhibit excellent weathering resistance to alternate wetting-drying cycles showcasing its exceptional durability under challenging environmental conditions. Irrespective of the MT content, curing environment, and the alkali activator concentrations, soil treated with MT-based geopolymers is found to satisfy both the strength (i.e. UCS = 0.75–1.5 MPa and CBR > 5%) as well as durability criteria (i.e. % loss in mass < 10%) specified by Indian Road Congress for subgrade soil. Moreover, the leaching study shows the concentrations of toxic elements (Zn, Cd, Fe, Pb, Ni etc.) to be within the permissible limits specified by USEPA thereby dispelling any environmental concerns associated with the use of MT-based geopolymers.