Dry Eye Syndrome In Patients Research Articles

Androgen Deprivation Therapy and the Risk of Newly Developed Dry Eye Syndrome in Patients with Prostate Cancer: A Nationwide Nested Case-Control Study in the Republic of Korea.

Background: We aimed to evaluate the association between androgen deprivation therapy (ADT) and newly developed dry eye syndrome (DES) in patients with prostate cancer. Methods: A nested case-control study was conducted. From the nationwide claims database of the Republic of Korea, 125,005 patients were included in the final analysis. Cases were defined as those newly diagnosed with DES during follow-up, and 12,654 patients were identified. The cases were matched with controls in a ratio of 1:4. Odds ratios (ORs) for newly developed DES associated with ADT were estimated using conditional logistic regression. Results: After matching, 7499 cases and 29,996 controls were selected. ADT was associated with a reduced risk of newly developed DES in patients with prostate cancer compared to no ADT (OR = 0.875; 95% confidence interval, 0.825-0.927; p < 0.0001). An accumulated dose of ADT < 1 year was associated with a reduced risk of incidental DES (OR = 0.811; 95% CI, 0.751-0.875; p < 0.0001), and a duration of 1-2 years was also associated with a reduced risk (OR = 0.890; 95% CI, 0.802-0.986; p = 0.026). No association was observed with an ADT duration of ≥2 years. Conclusions: The use of ADT, especially for shorter durations (<2 years), was associated with a reduced risk of newly developed DES in S. Korean patients with prostate cancer.

Basics of Diagnosis and Treatment of Dry Eye Syndrome During Refractive Surgery

Given the prevalence of refractive surgery in modern ophthalmological practice, when preparing a patient for this type of surgery, it is important to understand the multifactorial mechanism of the development of dry eye syndrome in this group of patients. Analysis of the literature data made it possible to identify key factors in the disruption of the tear formation process after refractive surgery, which include the intersection of the nerve endings of the cornea, which in turn reduces the frequency of blinking and the distribution of the tear film over the ocular surface, and also causes a violation regarding neurotrophic factors secreted by the nerve endings of the cornea . The presence of a postoperative inflammatory reaction, which has a specific course, manifested in a change in the biochemical properties of the tear, damage to the goblet cells of the conjunctiva during the creation of a vacuum during LASIK and SMILE, leading to a subsequent deficiency of mucin in the tear, changes in the curvature of the cornea caused by laser refractive surgery are factors influencing the development of dry eye syndrome after refractive surgery. When preparing a patient for refractive surgery, to reduce the risk of developing severe forms of dry eye syndrome, including corneal ulceration, it is necessary to take into account a history of systemic diseases and allergic reactions, especially in patients with high myopia. The influence of cosmetic procedures, such as eyelash extensions, eyelid tattooing, blepharoplasty, and the use of botulinum toxin in the periorbital area on the course of the postoperative period during refractive surgery, has been poorly studied. Research in this area opens up a new range of opportunities to reduce the incidence of dry eye syndrome in patients after refractive surgery and improve the quality of life of patients and patient satisfaction with the surgical intervention.

Characteristics of Dry Eye Syndrome in Patients with Mild Graves’ Ophthalmopathy

Characteristics of Dry Eye Syndrome in Patients with Mild Graves’ Ophthalmopathy

Dry eye syndrome associated with traumatic keratitis

Dry eye syndrome (DES) is an urgent problem in healthcare practice worldwide. Various diseases of the eye are of particular importance for the development of this syndrome. A special place among the diseases leading to symptomatic DES with ocular surface lesion belongs to corneal injuries of traumatic origin. The frequency of post-traumatic complications of the eye, especially the cornea, remains high due to its anatomical location. And often these patients are at risk of secondary DES. For the pathogenesis of DES after ke­ratitis, ultrastructural changes in the cells of different corneal layers and the toxic effect on the tear film layers of preservative-containing drugs used in the treatment of keratitis are important. The purpose of the study was to assess the severity of secondary DES in patients after traumatic keratitis and the effectiveness of hyaluronic acid combined with antioxidants in the treatment of this pathology. An ophthalmological examination, functional tests were made, and the Ocular Surface Disease Index was used to evaluate the symptoms and severity of the disease. The criteria for the effectiveness of the therapy with hyaluronic acid in combination with vitamins A and E four times a day were: reduction of corneal syndrome, increase in the tear film break-up time, a decrease in subjective discomfort. Clinical observation of patients with DES after traumatic keratitis showed that the use of hyaluronic acid can result in a significant reduction or complete disappearance of subjective symptoms of the disease, sustained improvement in vision and increased stability of the tear film. The use of these eye drops makes it possible to reach compliance and shorten the treatment period.

Frequency of dry eye syndrome in patients with multiple sclerosis: A cross-sectional case-control study

Introduction: Demyelination of the nerve fibers of the central nervous system is a main pathology of multiple sclerosis (MS), in which inflammation plays a major role. Studies have shown that inflammation is the leading cause of dry eye disorder. To investigate the association between inflammation and both diseases, we aimed to estimate the prevalence of dry eye syndrome (DES) in MS patients and its correlation with the severity of the disease and disability status. Methods: We enrolled 100 MS patients randomly and 100 healthy controls. DES was evaluated by Dry Eye questionnaire and Scoring System (DESS), tear break-up time (TBUT), tear meniscus height (TMH), and Schirmer 1 &amp; 2 tests in subjects. Furthermore, the leading disability in MS was assessed by a clinician (neurology professor) using the related questionnaire (Expanded Disability Status Scale). Results: According to the TBUT, THM, and Schirmer tests, the number of subjects with abnormal results was significantly higher in the MS group than in the control group. The severity of DES measured by the DESS was also higher in the MS group compared to control group. Also, there was a significant relationship between increasing disability and abnormal dry eye tests, especially in MS patients with EDSS scores&gt;4. Conclusion: The present study highlights the importance of considering dry eye disorder in MS patients as a possible consequence of inflammation. Also, our results suggested a significant relationship between dry eye disorder and the EDSS scores.

Complex therapy of the evaporative form of dry eye syndrome in patients after keratorefractive surgery

Introduction. Meibomian gland dysfunction (MGD) is considered as the leading cause of the evaporative dry eye syndrome (DES). At the same time the standard methods of DES treatment often allow to achieve only a short-term effect and the search of alternative methods to achieve remission for a longer period is required.Aim. To evaluate the effectiveness of a combined treatment of DES with MGD using transdermal Intense Pulsed Light (IPL) method combined with preservative-free sodium hyaluronate 0.18% eyedrops.Materials and methods. The study involved 60 patients (120 eyes) after refractive surgery (femtoLASIK) with DES and MGD aged 20 to 40 years with a follow-up period of 3 months. The patients were divided into two groups: main (30 patients) and control (30 patients). Patients of both groups were administered a preservative-free form of 0.18% sodium hyaluronate four times a day for 3 months. All studied patients underwent standard examination methods, indicators of DES were assessed along with an objective valuation of tear film parameters and the meibomian glands condition by mean of digital biomicroscopy using a MediWorks slit lamp before surgery and 7 days, 1, 2 and 3 months after refractive surgery.Results and discussion. A comparative analysis of therapy effectiveness in the main and control groups showed that OSDI scores (ocular surface disease index), non-invasive tear breakup time (NITBUT) and meibomian gland function improved after treatment in both groups, but in the main group (IPL) positive dynamics of indicators were more pronounced with a cumulative increase of effectiveness after subsequent sessions.Conclusion. A course of IPL therapy in combination with a course of sodium hyaluronate 0.18% for dry eye syndrome due to MGD reduces the time, allows for longer-term results of therapy and promotes earlier elimination of discomfort.

CHARACTERISTICS OF ACQUIRED OBSTRUCTION OF LACRIMAL PATHWAYS IN PATIENTS WITH CHRONIC TYPE 2 DIABETES AND COMBINED CONSERVATIVE AND SURGICAL TREATMENT INVOLVING ENT SPECIALISTS

Pathological changes in the lacrimal system such as dry eye syndrome in patients with diabetes are well described in modern literature, but no sufficient attention is paid to the problem of the lacrimal system in this group of patients. Currently, the established protocol for treating chronic dacryocystitis involves collaborative endoscopic endonasal dacryocystorhinostomy conducted by ophthalmic surgeons and ENT specialists. However, in patients with type 2 diabetes, there is a need to investigate the clinical effectiveness of this surgical approach.&#x0D; Purpose of this study is to evaluate the effectiveness of conservative and surgical treatment in patients with chronic dacryocystitis depending on the presence of type 2 diabetes and to determine the features of the postoperative period.&#x0D; Materials and methods. The study included 30 patients with chronic dacryocystitis and type 2 diabetes (main group) and 30 patients with chronic dacryocystitis without diabetes (control group), who underwent endoscopic endonasal dacryocystorhinostomy according to the standard technique. The results of the operation were evaluated in 2 months, 6 months and 2 years following the surgical interventions.&#x0D; Endoscopic endonasal dacryocystorhinostomy was considered as an effective technique for restoring unobstructed lacrimal drainage when it lead to the alleviation of tearing, and preventing re-infection of the lacrimal sac. Alongside conventional ophthalmological examinations, the assessment involved nasopharyngeal and lacrimal suction tests, reflux tests, lacrimal duct lavage, lacrimal canal probing, computer tomography, and endoscopic examination of the nasal cavity.&#x0D; Results and discussion. The effectiveness of surgical treatment in 2 months after the operation in patients of the main group (70% of patients) was 1.3 times, after 6 months (63.3% of patients) was 1.4 times, and in the remote period in 2 years (50% of patients) was 1.6 times lower than in patients of the control group (р&lt;0.05). Analyzing the presence of the main symptoms of chronic dacryocystitis in the dynamics of observation, it was noted that after endoscopic endonasal dacryocystorhinostomy the most frequent symptom was lacrimation, but its frequency in patients of the main group after 2 months (30% of patients) was 4.5 times, after 6 months (36.7% of patients) - 2.8 times, after 2 years (50% of patients) - 2.5 times higher than in patients of the control group (р&lt;0.05 ).&#x0D; The efficacy of surgical treatment's in 2 month following the operation in the main group patients (70%) was 1.3 times, after 6 months (63.3%) was 1.4 times, and in the long-term, 2 years post-operation (50%), was 1.6 times lower than in the control group patients (p&lt;0.05). Analyzing the dynamics of chronic dacryocystitis symptoms during observation, it was observed that following endoscopic endonasal dacryocystorhinostomy, lacrimation emerged as the most common symptom. However, its frequency in the main group patients was notably higher after 2 months (30%), being 4.5 times, after 6 months (36.7%) it was 2.8 times higher, and after 2 years (50%) it was 2.5 times higher compared to the control group (p&lt;0.05).&#x0D; Conclusions. In patients with type 2 diabetes, the clinical effectiveness of conservative and surgical treatment for chronic dacryocystitis is lower than in patients without diabetes, and the postoperative period has its own characteristics.

Assessing the prevalence and impact of dry eye syndrome in patients with migraine: A cross-sectional study

Assessing the prevalence and impact of dry eye syndrome in patients with migraine: A cross-sectional study

Study on relationship between intraocular pressure and hyperthyroidism

Thyroid-associated ophthalmopathy (TAO) represents a persistent autoimmune inflammatory condition impacting various ocular components, including orbital fat (OF), extraocular muscles (EOMs), the eyeball, and associated eye structures. This disorder is closely associated with autoimmune thyroid pathology. A body of research has indicated an elevated susceptibility to heightened intraocular pressure (IOP) and glaucoma among individuals with thyroid-related ailments. Nonetheless, certain studies have expressed reservations about affirming these conclusions. Furthermore, there exists a diversity of viewpoints regarding the optimal approaches for managing elevated IOP in TAO patients afflicted with ocular hypertensionA prospective research investigation was undertaken within the Department of Ophthalmology at a Tertiary Care Teaching Hospital, spanning a duration of 12 months. The techniques employed for the diagnosis of open-angle glaucoma (OAG) have been comprehensively outlined. Goldmann applanation tonometry was utilized to determine intraocular pressure (IOP). Employing a Zeiss FF3 fundus camera, a series of dilated stereoscopic 300-color retinal and optic disc images were captured. The evaluation of optic disc photographs was conducted by one of two evaluators, both of whom remained masked to the study's particulars, employing a customized protocol. In order to ascertain optic disc dimensions, adjustments for camera magnification were performed, accounting for the spherical equivalent refraction of each individual eye.A total of 90 patients were examined. Of the 90 cases, male preponderance was noted. Among 90 patients, 20 (22.2%) were hyperthyroid, 61 (67.8%) were hypothyroid, and 9 (10%) patients were euthyroid. In our study shows the frequency of different symptoms among the study group. Most of the patients came with complaint itching of (27.8%). The second most common symptom was foreign body sensation (21.1%). In this study shows the different types of signs among these two groups. In hyperthyroid lid, retraction was more common (12%). In hypothyroid lid, edema was more common (18.5%). Frequency of dry eye syndrome in patients with TD was present; 29 (26.4%) patients had dry eye disease. Among 90 patients, proptosis was present in 4 patients had proptosis. Most of the patients were myopic.Our results imply the potential link between intraocular pressure (IOP) and thyroid-related disorders, particularly in individuals undergoing thyroxine treatment. Conducting further comprehensive investigations to explore and substantiate this prospective association is advisable.

Современные аспекты этиопатогенеза и диагностики синдрома сухого глаза у пациентов рефракционного профиля

Modern literature materials on the main aspects of etiopathogenesis and diagnosis of dry eye syndrome in patients who plan to undergo keratorefractive surgery are presented. There are etiopathogenetic aspects of the development of induced dry eye syndrome after keratorefractive surgery. This requires examination of the ocular surface before and after surgery. There is a phasing in performing diagnostic screening of the xerosis of the ocular surface. A comprehensive diagnostic approach to the examination’s state of the ocular surface, which consists of subjective and objective data, the results of laboratory research methods, creates a holistic view of the homeostasis of the ocular surface in refractive profile patients. This diagnostic profile will determine the choice of optimal refractive surgery technology, patient management tactics and features of the course of the postoperative period. Key words: tear film, ocular surface, dry eye syndrome, refractive surgery

Predictive significance of genetic analysis of the development of dry eye disease of different origin

The aim of the study was to determine the prognostic significance of a panel of polymorphic gene markers in the development of dry eye syndrome in patients with primary Sjögren's syndrome and rheumatoid arthritis over a five-year follow-up period. Patients with a verified diagnosis of PSS and RA without signs of DED were examined (n=35 and n=42, respectively). The control group included 82 volunteers without AID and DED. The observation period was 5 years. Every year all study subjects underwent an ophthalmological clinical and functional examination. Dry eye disease had developed in groups of patients with AID with predisposing genotypes of polymorphic markers of the genes THBS1, MUC1, TRIM21, STAT4, PTPN22. The peak of DED development in these patients was in the third year of the follow-up. As a result of ROC analysis, it was found that the sensitivity and specificity of determining the predisposing genotypes of polymorphic markers of the THBS1, MUC1, TRIM21, STAT4, PTPN22 genes was 68 and 87%, respectively (p<0.0001). Genetic research methods are essential for minimally invasive early diagnosis of dry eye disease, and can subsequently become the basis for a personalized approach to its treatment.

Dry Eye Syndrome in Patients of Diabetes with and without Diabetic Retinopathy

Background: The present study was done to assess dry eye syndrome in patients with and without diabetic retinopathy. We compared symptoms and signs of dry eye syndrome in patients with and without retinopathy&#x0D; Methods: The study was conducted on cases of Type 2 diabetes mellitus with age ?35 years. The study participants were divided into two distinct groups. First group consists of diabetic patients with clinical evidence of diabetic retinopathy and second group with no evidence of diabetic retinopathy. 50 patients were enrolled in each of the above two groups after written informed consent.&#x0D; Results: All Signs of dry eye disorder were found more commonly in patients with diabetic retinopathy(42.00%) as compared to those without diabetic retinopathy(18.00%).&#x0D; Conclusion: Dry eye syndrome was positively correlated with the presence of diabetic retinopathy in this study. Any diabetic patient complaining of dry eye symptoms should be screened for diabetic retinopathy.&#x0D; Keywords: Dry eye, Diabetes, Retinopathy

Dry eye syndrome in patients with allergic eye disease

Antihistamines favors the Meibomian gland dysfunction (MGD), this being the main cause of dry eye syndrome (DES); moreover, chronic inflammation in allergic eye disease (AED) can generate DES over time and both pathologies can damage the ocular surface.

Dry eye syndrome in patients with cardiovascular pathology

Dry eye syndrome in patients with cardiovascular pathology

The Presence of Dry Eye Syndrome in Patients with Fibromyalgia: A Cross-sectional Controlled Study

Our aim is to investigate the presence of dry eye in fibromyalgia (FM) patients with using a self-reported questionnaire and objective tests. This study included 20 patients who were newly diagnosed FM and 20 healthy controls. Both groups were evaluated with ocular surface disease scale (OSDI), non-anesthetized Schirmer-I test, meibography, tear meniscus assessment, fluorescein tear break time (FBUT), non-invasive tear break time (NITBUT) and corneal fluorescein staining (CFS) tests. OSDI questions were significantly higher, FBUT values were significantly lower and FBUT values were significantly correlated with OSDI in FM patients. (p&amp;lt;0.05, p=0.007). There was no significant difference in other parameters.In this context, it was observed in this study that FM patients had significantly more ocular discomfort than healthy controls. Early recognition of comorbidities by physicians ensures the success of FM treatment with comorbidities.

Комплексное лечение синдрома сухого глаза у пациентов с синдромом Шегрена путем применения препарата бесконсервантных капель, содержащих гиалуронат натрия 0,4 % и комплекса нутрицевтиков

The aim. To increase the effectiveness of treatment of dry eye syndrome in patients with Sjogren’s syndrome with preservative-free drops which contain 0.4 % sodium hyaluronate and nutraceutical complexes nutraceuticals. Materials and methods. The study was conducted on the basis of the Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine. The study included 64 patients aged 34 to 58 years (128 eyes) with dry eye syndrome accompanied by Sjogren’s syndrome. Examination of patients included: assessment of complaints, visometry, refractometry, bacterial culture of the conjunctiva and nasopharynx, biomicroscopy, ophthalmoscopy, Schirmer and Norn tests, assessment of "comfort of application of drops" on the questionnaire. This study is an extension of the study previously conducted at the premises of the Filatov Institute of Eye Diseases and Tissue Therapy of The National Academy of Medical Sciences of Ukraine on the effectiveness of preservative-free eye drops containing 0.4 % hyaluronic acid in the treatment of Sjogren’s syndrome. Results. Prior to the appointment of comprehensive treatment with instillations, the Norn test showed 6.55 s (SD 1.57) with a minimum of 3 s, a maximum of 9 s, and a median of 6.5 s. After 3 months of treatment the Norn test score in the 1st group averaged 14.66 (SD 1.07) vs. 13.86 (SD 1.07) in the 2nd group, but the difference was not statistically significant (p=1.0). The mean number of required instillations per day was 4.1 (SD 1.04) in the 1st group and 5.27 (SD 1.11) in the 2nd group. Conclusion. Instillations of preservative-free drops containing sodium hyaluronate 0.4 % (in a bottle with an innovative ophthalmic squeeze dispenser (OSD)) in combination with a nutraceutical complex in the treatment of dry eye syndrome in patients with Sjogren’s syndrome is effective and allows achieving a stable and long-term effect. Keywords: Sjogren’s syndrome, hyaluronic acid, nutraceuticals, artificial tear, Schirmer test, Norn test, dry eye syndrome, tear film.

Risk of Dry Eye Syndrome in Patients with Orbital Fracture: A Nationwide Population-Based Cohort Study.

This study aimed to investigate whether orbital fracture increases the risk of dry eye syndrome (DES) and identified the profile of prognostic factors. We studied a cohort from the Taiwan National Health Insurance Research Database (NHIRD). Overall, 46,179 and 184,716 participants were enrolled in the study and control groups, respectively. Each patient in the case group was age- and gender-matched to four individuals without orbital fracture that served as the control group. Cox proportional hazards analysis regression was used to estimate the risks of incident DES. During the follow-up period, the case group was more likely to develop incident DES (0.17%) than the control group (0.11%) (p = 0.001). Multivariate Cox regression analysis demonstrated that the case group had a 4.917-fold increased risk of DES compared to the controls. In the stratified age group, orbital fracture had the highest impact on patients aged 18–29 years. Furthermore, patients with orbital roof fracture have a greater risk of developing DES. Regardless of whether having received surgery or not, the patients with orbital fracture have higher risks of DES. Our study demonstrated that orbital fracture increases the risk of developing subsequent DES. Early recognition by thorough examinations with raised awareness in the clinical setting could preserve visual function and prevent further complications.

Ocular surface changes in Graves' ophthalmopathy.

Many patients with Graves' ophthalmopathy (GO) suffer from dry eye syndrome (DES), and this is one of the most common reasons of eye discomfort in patients with GO. The prevalence of DES in patients with GO is significantly higher than normal subjects. The ocular surface changes involving changes in tears, cornea, conjunctiva and glands occur in GO patients. However, the mechanism of how DES occurs in GO still remains unclear. In this review, the ocular surface changes were illustrated and analyzed the reasons for high prevalence of DES in GO patients.

Pengaruh HbA1c Terhadap Sindroma Mata Kering Pada Pasien Diabetes Mellitus di Surabaya

&lt;p&gt;&lt;strong&gt;Abstract&lt;/strong&gt;&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes mellitus is a public health problem experienced by many countries and becomes a serious problem, affecting health in the world. Various complications of DM related to the surface of the eye is dry eye syndrome. Dry eye syndrome is an eye disorder with symptoms of discomfort, pain, dryness and foreign body sensation in the eye. The level of glycosylated hemoglobin (HbA1c) is one indicator of DM and it is stated that the prevalence of dry eye syndrome is significantly higher in DM sufferers than in healthy individuals. The Aim of this study to know the effect of HbA1c on dry eye syndrome in patients with diabetes mellitus &lt;strong&gt;Method :&lt;/strong&gt;. This study used a cross sectional method and the sampling method used was purposive sampling. Samples taken as many as 34 people are patients with diabetes mellitus aged 18-55 years who have HbA1c results seen from medical records at the Public Health Center Jagir Surabaya. The research data was taken using the Dry Eye Questionnaire (DEQ), interviews and Schirmer Test I. The research data was then analyzed using a contingency test.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Result: &lt;/strong&gt;The significance value of the HbA1c test with the Schirmer I Test showed p = 0.026; that’s means a significant effect between HbA1c levels on dry eye syndrome with the Schirmer I Test and the significance value of the HbA1c test with the DEQ questionnaire shows p &amp;lt;0.001; that’s means a significant effect between HbA1c levels on dry eye syndrome and DEQ questionnaire, performed on patients with diabetes mellitus in Jagir Health Center, Surabaya City&lt;/p&gt;&lt;pre&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;There is an influence of HbA1c levels on dry eye syndrome&lt;/pre&gt;&lt;p&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;em&gt;K&lt;/em&gt;&lt;em&gt;ey Word&lt;/em&gt;&lt;em&gt; : D&lt;/em&gt;&lt;em&gt;ry Eye&lt;/em&gt;&lt;em&gt;, &lt;/em&gt;&lt;em&gt;Dry Eye Questionnaire, HbA1c&lt;/em&gt;&lt;em&gt;, &lt;/em&gt;&lt;em&gt;Diabetes Mellitus&lt;/em&gt;&lt;em&gt;.&lt;/em&gt;&lt;/p&gt;&lt;em&gt;&lt;/em&gt;

Evaluation of Dry Eye Syndrome in Patients With Familial Mediterranean Fever: A Cross-sectional Study

Objective. It has been reported that some autoimmune diseases are associated with dry eye syndrome. There are limited studies that relates dry eye syndrome in patients with Familial Mediterranean fever (FMF). The aim of this study is to evaluate the relationship between dry eye syndrome in patients with FMF comparing with healthy controls. Methods. Prospective cross-sectional study was carried out in departments of physical medicine and rehabilitation and ophthalmology clinics in a tertiary public institution with a sample of 46 participants including 23 FMF patients and 23 healthy controls. Detailed eye examination was performed in all cases and indicators of xerophthalmia were assessed by Schirmer-I test, tear break-up time (TBUT) and ocular surface disease index (OSDI). In patient group; results of FMF gene analysis, acute phase reactants, concomitant diseases and number of FMF attacks were noted. Results. The average Schirmer-I test results for right-eye were recorded as 14.74±8.38 for the FMF group and 13.09±10.54 for the healthy group; the TBUT scores were 14.69±5.32 in FMF group and 15±6.45 in the healthy group; and OSDI scores were 9.04±2.75 and 10.86±1.77 in the FMF group and the healthy control, respectively. There were no statistically significant differences between FMF and control groups in terms of Schirmer-I, TBUT, and OSDI scores (all p＞0.05). No correlation was identified between acute phase reactants and the OSDI, TBUT and Schirmer-I tests for right-eye (all p＞0.05). Conclusion. This study identified no correlation between dry eye and FMF. Ocular pathology is rare and infrequently reported in FMF. (J Rheum Dis 2020;27:270-276)