Drinking Group Research Articles

Feasibility of introducing effective alcohol harms reduction strategies in a low regulation region: A qualitative study from Hong Kong

To counter the harms of excessive alcohol use, the World Health Organization (WHO) outlined a series of alcohol policy recommendations, including the most cost-effective “Best Buys”. This study aims to obtain key stakeholder views on feasibility of implementing various publicly endorsed alcohol policies in Hong Kong, a relatively low alcohol consumption region with few extant alcohol regulations. Between 2019 and 2021, we conducted semi-structured interviews with stakeholders involved in alcohol policy adoption and implementation. Interviewees included hospitality/alcohol sales workers (n = 13) and government officers (n = 4). The stakeholders noted that although WHO advocacy facilitated local policy considerations, the adoption of stringent measures was challenged by low political priority due to the low visibility of harms. For implementing strategies, the stakeholders cited alignment with social norms as a major facilitator, whereas law enforcement difficulties and resistance from industry/business sectors were viewed as major obstacles. There was a general belief that population-level alcohol policies would be effective for certain groups of drinkers but would also harm the local economy and detract from Hong Kong's image as a “world city”. Hong Kong may not be ready to adopt a wide range of highly restrictive population-level alcohol policies. Local governments should carefully consider contextual factors when following international recommendations.

Association of serum phthalates exposure with incident type 2 diabetes risk in Chinese population: A nested case-control study

Prospective epidemiological evidence was lacking on the association of phthalates (PAEs) exposure with incident type 2 diabetes mellitus (T2DM) risk. In present nested case-control study, we identified 1006 T2DM cases and matched 1006 controls based on Dongfeng-Tongji cohort study, and 6 PAEs were detected in baseline serum. The conditional logistic regression model, Bayesian kernel machine regression (BKMR) model and Quantile-based g-computation were applied to evaluate the associations of determined PAEs, either as individuals or as a mixture, with incident T2DM risk. Subgroup analysis was conducted to identify the potential sensitive population of PAEs effects on T2DM. After multiple adjustment, no statistically significant association was observed between single or mixture of PAEs and incident T2DM risk in the whole population. However, serum levels of Di-n-butyl phthalate (DnBP) [OR= 2.06; 95% CI: (1.11–3.96)], Σdibutyl phthalate (ΣDBP) [OR= 1.96; 95% CI: (1.06–3.76)], and Σlow-molecular- weight phthalate (ΣLMW) [OR= 2.27; 95% CI: (1.17–4.57)] were significantly associated with T2DM in current drinker group. Moreover, significant potential interactions were observed among Di-iso-butyl phthalate (DiBP), DnBP, Butyl-benzyl phthalate (BBP), ΣDBP, and ΣLMW with drinking status on T2DM risk (P for interaction = 0.036, 0.005, 0.049. 0.010, and 0.005). We did not find significant associations between serum PAEs levels and T2DM in the whole population. However, current alcohol drinkers expose to higher levels of DnBP, ΣDBP, and ΣLMW had higher risk of T2DM.

Changes in alcohol consumption habits and risk of atrial fibrillation: a nationwide population-based study.

Heavy alcohol consumption is an established risk factor for atrial fibrillation (AF). However, the association between habitual changes in heavy habitual drinkers and incident AF remains unclear. The aim of this study was to evaluate whether absolute abstinence or reduced drinking decreases incident AF in heavy habitual drinkers. Atrial fibrillation-free participants with heavy alcohol consumption registered in the Korean National Health Insurance Service database between 2005 and 2008 were enrolled. Habitual changes in alcohol consumption between 2009 and 2012 were classified as sustained heavy drinking, reduced drinking, and absolute abstinence. The primary outcome measure was new-onset AF during the follow-up. To minimize the effect of confounding variables on outcome events, inverse probability of treatment weighting (IPTW) analysis was performed. Overall, 19 425 participants were evaluated. The absolute abstinence group showed a 63% lower incidence of AF (IPTW hazard ratio: 0.379, 95% confidence interval: 0.169-0.853) than did the sustained heavy drinking group. Subgroup analysis identified that abstinence significantly reduced incident AF in participants with normal body mass index and without hypertension, diabetes, dyslipidaemia, heart failure, stroke, chronic kidney disease, or coronary artery disease (all P-value <0.05). There was no statistical difference in incident AF in participants with reduced drinking compared with sustained heavy alcohol group. Absolute abstinence could reduce the incidence of AF in heavy alcohol drinkers. Comprehensive clinical measures and public health policies are warranted to motivate alcohol abstinence in heavy drinkers.

Affective imagery boosts the reward related delta power in hazardous drinkers.

The Reward Positivity (RewP) is an event-related potential component with a delta band spectral representation that is elicited by reward receipt. Evidence suggests that RewP is modulated by both reward probability as well as affective valuation ("liking"). Here we determined whether RewP is a marker of enhanced hedonic salience of alcohol images in hazardous drinkers. We recruited 54 participants (Hazardous Drinkers=28, Control=26) who completed a reinforcement learning task with affective versus alcohol imagery during feedback. The learning task used images of puppies vs. alcohol paired with reinforcing feedback. Both groups rated categories of affective images (puppies, scenery, babies, neutral) similarly, but the hazardous drinking group rated alcohol significantly higher. There were no group differences in performance or in RewP amplitudes, even as a function of alcohol imagery. Contrary to prior findings, we did not observe a significant correlation between alcohol image rating and alcohol-specific RewP amplitude, although we did observe this relationship with the alcohol-specific delta band spectral representation of RewP. Within hazardous drinking group, there was significant correlation between hazardous drinking (AUDIT score) and alcohol-specific RewP indicating an inter-individual influence of drinking habits on affect specific RewP. These findings suggest a domain-specific enhancement of reward responsiveness in hazardous drinkers.

Non-alcoholic beer reduces flexibility of ideas: Randomized control trial study in Japan

This study examined whether non-alcoholic beverages enhanced individuals’ creativity. Participants were randomly allocated to either the non-alcoholic drink group or the water group. They completed the pre-session creativity task and then drank non-alcoholic drinks or water during the drinking session. Thereafter, they completed the post-session creativity task. Two experiments were performed in the study. The results of Experiment 1 (non-alcoholic drink: n = 18; water: n = 17), wherein participants had little experience with alcohol consumption and the sample size was small, show that non-alcoholic beverages did not have any effect. The results of Experiment 2, (non-alcoholic beer: n = 68; water: n = 65), which was conducted among participants with a long intake history and a sufficient number of samples (the required sample size was calculated to be 128), showed that flexibility was higher in the water group than in the non-alcoholic beer group. A previous study showed that alcohol consumption reduced flexibility. Therefore, classical conditioning may have caused non-alcoholic beverages to produce a conditioned response of reduced flexibility, a response similar to the effect of alcoholic beverages.

A new statistical model for binge drinking pattern classification in college-student populations.

Binge drinking (BD) among students is a frequent alcohol consumption pattern that produces adverse consequences. A widely discussed difficulty in the scientific community is defining and characterizing BD patterns. This study aimed to find homogenous drinking groups and then provide a new tool, based on a model that includes several key factors of BD, to assess the severity of BD regardless of the individual's gender. Using the learning sample (N1 = 1,271), a K-means clustering algorithm and a partial proportional odds model (PPOM) were used to isolate drinking and behavioral key factors, create homogenous groups of drinkers, and estimate the probability of belonging to these groups. Robustness of our findings were evaluated with Two validations samples (N2 = 2,310, N3 = 120) of French university students (aged 18-25 years) were anonymously investigated via demographic and alcohol consumption questionnaires (AUDIT, AUQ, Alcohol Purchase Task for behavioral economic indices). The K-means revealed four homogeneous groups, based on drinking profiles: low-risk, hazardous, binge, and high-intensity BD. The PPOM generated the probability of each participant, self-identified as either male or female, to belong to one of these groups. Our results were confirmed in two validation samples, and we observed differences between the 4 drinking groups in terms of consumption consequences and behavioral economic demand indices. Our model reveals a progressive severity in the drinking pattern and its consequences and may better characterize binge drinking among university student samples. This model provides a new tool for assessing the severity of binge drinking and illustrates that frequency of drinking behavior and particularly drunkenness are central features of a binge drinking model.

FAM13A polymorphisms are associated with a specific susceptibility to clinical progression of oral cancer in alcohol drinkers

BackgroundSingle nucleotide polymorphism (SNP) is a genetic variation that occurs when a single nucleotide base in the DNA sequence varies between individuals and is present in at least 1% of the population. Genetic variants in FAM13A are associated with different types of chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and lung cancer. However, there is little literature on the association of FAM13A genotypes with oral cancer. Therefore, this project will explore the correlation between the FAM13A genotype and the formation of oral cancer.MethodsIn this project, we will examine the presence of gene polymorphisms gene polymorphisms of rs1059122, rs3017895, rs3756050, and rs7657817 in the FAM13A gene exon, and combine the expression of these genes to try to clarify the impact of the FAM13A gene polymorphism on oral cancer. First, four loci (rs1059122, rs3017895, rs3756050, and rs7657817) of the FAM13A SNP were genotyped using TaqMan allelic discrimination.ResultsBy estimating OR and AOR, FAM13A exhibited different genotypic variables in four SNPs that were not statistically significant between controls and patients with oral cancer. The results of the general analysis showed that different distributions of allelic types did not affect clinical stage, tumour size, lymph node invasion, distant metastasis, and pathological differentiation status. However, in the alcohol drinking group specifically, patients with the rs3017895 SNP G genotype had a 3.17-fold (95% CI, 1.102–9.116; p = 0.032) increase in the well differentiated state of cells compared to patients with the A allele.ConclusionsOur results suggested that the SNP rs3017895 FAM13A could contribute to oral cancer. More sample studies are needed in the future to confirm our results and more functional studies are needed to investigate their relevant roles in the development of oral cancer.

Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest.

Habitual coffee consumers justify their life choices by arguing that they become more alert and increase motor and cognitive performance and efficiency; however, these subjective impressions still do not have a neurobiological correlation. Using functional connectivity approaches to study resting-state fMRI data in a group of habitual coffee drinkers, we herein show that coffee consumption decreased connectivity of the posterior default mode network (DMN) and between the somatosensory/motor networks and the prefrontal cortex, while the connectivity in nodes of the higher visual and the right executive control network (RECN) is increased after drinking coffee; data also show that caffeine intake only replicated the impact of coffee on the posterior DMN, thus disentangling the neurochemical effects of caffeine from the experience of having a coffee.

1542-P: Commercially Available Aspartame-Based Sweetener Damages Morphology of Major Organs Both in Normal and Type 2 Diabetic Rats

Non-nutritive sweeteners (NNS) such as aspartame have become highly popular as sugar substitutes for diabetics. Majority of studies have reported controversial results and used aspartame in its pure form, which is not consumed by people practically. Hence, the present study was aimed at investigating the effects of commercially available aspartame-based sweetener on diabetes related parameters and its associated complications in both normal and type 2 diabetic rats. Seven-week-old male Sprague-Dawley rats were randomly divided into four groups, namely: Normal Control (NC), Toxicological Aspartame (TASP), Diabetic Control (DBC) and Diabetic Aspartame (DASP). Type 2 diabetes was induced experimentally in the DBC and DASP groups only and animals with non-fasting blood glucose levels &amp;gt;300 mg/dL were considered as diabetic. During 13 weeks experimental period, the control groups received normal drinking water, whilst TASP and DASP groups were given aspartame-containing NNS solutions, ad libitum, at concentrations equivalent to the sweetness of 20% and 10% sucrose solution, respectively. Treatment with toxicological aspartame resulted in significantly reduced serum fructosamine and creatinine levels in normal rats, when brain, heart, liver, kidney and pancreatic tissue morphologies were significantly damaged in both normal and diabetic rats. The data of this study suggest that although aspartame-based NNS may not have higher degree of detrimental effects on diabetes associated parameters, the significantly damaged morphology of the major organ tissues as well as deterioration of related serum biomarkers both in normal and diabetic conditions raises a concern of its use as a NNS in various food and food products. Disclosure S.N.Dlamini: None. S.Islam: None. Funding South African Sugar Association (Project 233)

Association of serum uric acid with risk of stroke in US adults: A cross-sectional study from NHANES 1999–2020

Background and aimsThe validity of high uric acid levels as an independent cause of stroke remains controversial, and the association between its low concentration and stroke is unclear. This study determines how different serum uric acid (SUA) levels are associated with stroke risk. MethodsThis cross-sectional study used continuous National Health and Nutrition Examination Survey data in the United States during 1999–2020. The SUA levels of 6.0, 6.8, and 9.0 mg/dL were all considered as cut-off points. Restricted cubic spline interpolation and logistic regression models were used to evaluate the different associations. Subgroup analyses and sensitivity analyses were conducted to evaluate the influence of multiple factors on the outcomes. ResultsThe study included 23,413 participants aged ≥ 20 years. A J-shaped curve existed between SUA and stroke risk, and the risk of stroke was positively correlated with SUA levels in the overall population. Subgroup analysis of all adults in the SUA 6.8–9.0 mg/dL group showed that stroke risk for non-Hispanic white, obese, ex-smoker, and heavy drinking groups was increased, but for the other Hispanic group was reduced. In the SUA < 6.0 mg/dL group, stroke risk for ex-smoker, heavy drinkers, and no chronic kidney disease groups was increased. ConclusionOur findings indicate a J-shaped relationship between SUA levels and stroke risk. Low and high SUA levels increased stroke risk for different populations, except in the other Hispanic population. Early SUA management is highly significant for stroke prevention in high-risk populations.

Стан глутатіонової системи головного мозку щурів за умов споживання енергетичного напою

The paper presents the results of studies of the energy drink influence on the state of the glutathione system of the rat brain. Energy tonics belong to a group of drinks containing a large number of active components that are able to stimulate the central nervous system of a person and to increase physical performance, as well as to affect circadian rhythms, extending the period of wakefulness. Literary sources also indicate the negative impact of energy drinks on certain functional systems of the human body. The study was carried out on white rats of the Wistar line weighing 180–200 g, which were on a standard vivarium diet under regulated microclimate parameters (humidity, lighting and temperature regime). All experiments on animals were conducted in compliance with the requirements of the European Convention for the Protection of Vertebrate Animals Used for Experimental and Scientific Purposes (Strasbourg, 1986). A non-inhalation method of anesthesia was used to collect the necessary material, namely intramuscular injection of sodium thiopental at the rate of 60 mg/kg. The experimental animals were divided into 5 groups according to the logical criterion of sample formation: 1st (control group) — rats received drinking water; 2nd — the animals received an energy drink for a month, the material was collected on the 1st day after the end of energy drink consumption; 3rd — animals that received an energy drink for a month, the material was collected on the 10th day after the end of the experiment; 4th — the animals received an energy drink for a month, the material was collected on the 20th day after the end of the experiment; 5th — the rats received an energy drink for a month, the material was collected on the 30th day after the end of the experiment. Determination of the activity of enzymes of the glutathione system (glutathione reductase, glutathione peroxidase and glutathione transferase) and the enzyme of the pentose phosphate pathway (glucose-6-phosphate dehydrogenase) was performed using the enzymatic method. The consumption of an energy drink by experimental groups of animals leads to changes in the activity of enzymes of the glutathione system: an increase in the activity of glutathione reductase in the 2nd, 4th, 5th groups, at the same time as a decrease in the activity of this enzyme in representatives of the 3rd group of animals, the activity of glutathione peroxidase increased in the 4th, 5th and decreased in 2nd and 3rd groups, an increase in glutathione transferase activity was observed in all experimental animals. The activity of the enzyme glucose-6-phosphate dehydrogenase increased in 2.3 and decreased in 4.5 studied groups. The obtained results demonstrated a significant influence of the energy drink on the state of antioxidant protection of the brain tissues of experimental animals, in particular on the state of the glutathione system. The interpretation of enzyme activity indicators proves that energy group drinks can lead to further violations of the ability to maintain the stability of the body’s internal environment.

Association Between Alcohol Expectancy and Drinking Behaviors in Summer Vacation and Last Year Among College Students.

Drinking in summer vacation, as an important part of college students' drinking behavior, has rarely been studied. At present, there is no research to explore the association between alcohol expectancy and college students' drinking behavior during the summer vacation. A total of 487 college students were selected from three universities in Chongqing from July 30, 2017, to August 30, 2017, by cluster sampling. The electronic questionnaires were distributed to complete the anonymous survey related to drinking. The questionnaire on drinking mainly included baseline characteristics, influencing factors related to drinking, drinking behavior in the last year and summer vacation, and alcohol expectancy. Independent sample t-test and one-way ANOVA were used for multi-factor analysis. Multi-level logistic regression analysis and ordered logistic regression analysis were used for multivariate analysis. The past drinking rate in the study group was 86.24%. In the past year, the drinking rate and binge drinking rate of college students were 63.24% and 23.20%. In summer drinking, these two indicators were 29.57% and 8.42%, respectively. About 92.50% of the moderate and heavy drinking groups among college students had drinking behavior during the summer vacation. The average negative expectancy among college students was 3.26 ± 0.87 while the average positive expectancy was 2.63 ± 0.66. In drinking last year, positive expectancy was a risk factor for occasional and light drinking compared with those of non-drinkers (P<0.05). In summer vacation drinking, compared with those of non-drinkers, negative expectancy was a protective factor for occasional drinking (OR: 1.847, 95% CI: 1.293-2.638), negative expectancy and positive expectancy were both influencing factors for light drinking (P<0.05). The drinking rate in the study group was at a high level in the past. The association between alcohol expectancy and drinking behavior among college students would be different according to the period and amount of drinking.

0305 Use of Sleep Medication Increases with Greater Severity of Hazardous Alcohol Use

Abstract Introduction Hazardous alcohol use correlates with greater insomnia, potentially leading to increased use of sleep medications. However, combining sleep medications with alcohol can yield serious and even fatal health consequences. We examined the relationship between alcohol use and sleep medication use during the first year of the COVID-19 pandemic and hypothesized that greater alcohol use would correlate with increased use of sleep medication. Methods N=3,930 English-speaking adults from across the U.S. (Mage=37.2, SD=12.4) completed the Pittsburgh Sleep Quality Index (PSQI) and the Alcohol Use Disorders Identification Test (AUDIT) at one of four timepoints (April, July, and October of 2020 and in January of 2021). Individual use of sleep aids was measured by ranking them from 0 (none) to 2 (once or twice a week or more). Additionally, alcohol use was ranked from 0-3 where a higher score indicated higher alcohol dependence. Results Alcohol use was modestly but positively correlated with sleep medication use (r = 0.183, p&amp;lt; 0.001). A chi-square analysis showed that the proportion of people reporting heavy use of sleep medications increased among those reporting greater severity of hazardous alcohol use (p&amp;lt; 0.001). Specifically, 21.8% of those in the non-hazardous drinking category reported heavy use of sleep medications, while 25.3% of those in the hazardous drinking group described heavy sleep medication use. For those meeting criteria for probable alcohol dependence, 39.7% reported heavy sleep medication use, and 57.3% meeting criteria for severe alcohol dependence reported heavy sleep medication use. Conclusion We found that individuals who scored higher on alcohol use scored higher on sleep medication use, consistent with our hypothesis. These results show that during the COVID-19 pandemic, hazardous alcohol use and sleep medication use were significantly associated. Such findings are concerning, because when combined, alcohol and sleep medications can lead to serious health consequences, including impaired neurocognitive functioning, sleep disruption, parasomnias, risk of overdose, and even death. Given the potential severe risks associated with this behavior, increased clinical assessment, monitoring, and counseling about the dangers of mixing sleep medication with alcohol is warranted. Further work should identify the causal direction and potential mediating factors driving these associations. Support (if any)

Identifying and describing trajectories of alcohol use frequency and binge drinking frequency among those age 15-30 in a national cohort of U.S. adolescents: a group-based trajectory modeling approach.

Analyzing long-term trajectories of alcohol use has the potential to strengthen policy and intervention priorities and timing. We identified and described trajectories of alcohol use and binge drinking frequency from mid-adolescence to early adulthood and measured the association of the role of early drinking initiation with trajectory membership. Longitudinal cohort study SETTING: United States PARTICIPANTS: The National Longitudinal Survey of Youth 1997 is a nationally representative cohort of youth age 12-16 at baseline. The analytic sample included individuals who participated in >2 annual interviews between age 15 and 30 (n=8,809). Participants self-reported the number of days in the past 30 days they: (1) drank alcohol and (2) binge drank [>5 drinks in one occasion]. We used group-based trajectory modeling to identify distinct trajectories from age 15-30 of past 30-day drinking and past 30-day binge drinking. Using multinomial logistic regression, we evaluated associations between early drinking initiation (≤14 years) and key demographics with trajectory membership. We identified 5 past 30-day drinking groups: late-escalating (16.0%), moderate-frequency (19.0%), high-frequency (11.1%), low-frequency (35.4%) and no/infrequent (18.4%). Early drinking initiation (versus later) was associated with higher odds of membership in the moderate (adjusted multinomial odds ratio [aMOR] = 4.32; 95% confidence interval [CI]: 3.65, 5.12) and high-frequency groups (aMOR = 4.17; 95%CI: 3.50, 4.97) than in the no/infrequent comparator trajectory. We identified 5 groups with distinct binge drinking frequency patterns: later escalating (9.9%), high-frequency (3.9%), low frequency (28.7%), earlier onset (9.5%), and no/infrequent (48.0%). Early initiation was associated with increased odds of membership in earlier onset and high-frequency groups compared with the no/infrequent group. For both outcomes additional differences in probability of group membership were identified by gender, racial identity, parental factors (religiosity, high school completion), and household characteristics (household size, income, and region of residence). Youth in the United States appear to follow heterogeneous drinking and binge drinking trajectories from adolescence into adulthood. These may include higher-use trajectories as well as trajectories with different escalation timing (e.g., earlier vs. later). Early initiation of drinking may increase risk of membership in higher- and earlier-use trajectory groups.

A comprehensive evaluation of the longitudinal association between alcohol consumption and a measure of inflammation: Multiverse and vibration of effects analyses

BackgroundModerate alcohol consumption appears to be associated with reduced inflammation. Determining whether this association is robust to common variations in research parameters has wide-reaching implications for our understanding of disease aetiology and public health policy. We aimed to conduct comprehensive multiverse and vibration of effects analyses evaluating the associations between alcohol consumption and a measure of inflammation. MethodsA secondary analysis of the 1970 British Birth Cohort Study was performed, using data from 1970 through 2016. Measurements of alcohol consumption were taken in early/mid-adulthood (ages 34 and 42), and level of inflammation marker high-sensitivity C-reactive protein (hsCRP) at age 46. Multiverse analyses were applied to comparisons of low-to-moderate consumption and consumption above various international drinking guidelines with an ‘abstinent’ reference. Research parameters of interest related to: definitions of drinking and reference groups; alcohol consumption measurement year; outcome variable transformation; and breadth of covariate adjustment. After identifying various analytic options within these parameters and running the analysis over each unique option combination, specification curve plots, volcano plots, effect ranges, and variance decomposition metrics were used to assess consistency of results. ResultsA total of 3101 individuals were included in the final analyses, with primary analyses limited to those where occasional consumers served as reference. All combinations of research specifications resulted in lower levels of inflammation amongst low-to-moderate consumers compared to occasional consumers (1st percentile effect: −0.21; 99th percentile effect: −0.04). Estimates comparing above-guidelines drinking with occasional consumers were less definitive (1st percentile effect: −0.26; 99th percentile effect: 0.43). ConclusionsThe association between low-to-moderate drinking and lower hsCRP levels is largely robust to common variations in researcher-defined parameters, warranting further research to establish whether this relationship is causal. The association between above-guidelines drinking and hsCRP levels is less definitive.

COMPARISON BETWEEN SPORTS DRINK AND COCONUT WATER ON CARDIOVASCULAR ENDURANCE PERFORMANCE AMONG FOOTBALL PLAYERS

A sports drink is a drink containing electrolytes and glucose, meanwhile coconut drink is known as a natural source of sports drink. Both drinks have the benefit of restoring energy and electrolyte, especially when ingested during strenuous physical activity that requires maximum endurance performance. The purpose of this study was to compare the effects of sports drinks and coconut drinks in enhancing cardiovascular endurance performance among UiTM football players. A total of 24 male participants representing Universiti Teknologi MARA Football Club (UiTM FC) were recruited. Participants were randomly assigned into three groups that are isotonic drink group (IDG) (n=8), the coconut drink group (CDG) (n=8), and the control group (n=8). Cardiovascular endurance performance was determined based on bleep test results at the pre-test and post-test. The intervention was conducted by giving a different type of drink according to the assigned group. IDG received 100 plus isotonic drink, CDG received a Vita Coco drink and CG were only given plain water. After the end of the pre-test session, the participants were given 2-hour to rest, and drinks were given according to their group. After 2-hour of rest, the participants continue with the post-test. The level of VO2 max was measured by an equation based on the bleep test results. The result shows there was a significant increment in pre-post-test VO2 max level within all groups, showing improvement in the mean level of VO2 max at post-test. The mean of pre-post-test VO2 max for the three respective groups was IDG 47.53 ± 6.32 to 49.46 ± 5.88 ml/kg/min, CDG 47.01 ± 3.45 to 48.81 ± 3.29 ml/kg/min and CG 47.06 ± 3.11 to 47.91 ± 3.43 ml/kg/min. However, there was no significant difference (p=0.276) between groups and pre-post-test VO2 max level. Looking at between groups effect, there was no significant effect (p=0.900) between these three groups and their VO2 max level. In conclusion, there was a significant positive change in the participant's pre-post-test VO2 max level for all three groups across two different periods at the pre-test and post-test. This suggests ingesting drinks between exercises substantially improved football players' cardiovascular endurance performance. However, there was no significant difference in the participants' cardiovascular endurance performance between the three groups. This indicates the type of drink does not influence the cardiovascular endurance performance among these football players.

Differences in Next-Day Adverse Effects and Impact on Mood of an Evening of Heavy Alcohol Consumption between Hangover-Sensitive Drinkers and Hangover-Resistant Drinkers.

The combination of negative mental and physical symptoms which can be experienced after a single episode of alcohol consumption, starting when blood alcohol concentration (BAC) approaches zero, are collectively referred to as the alcohol hangover. Previous research revealed that 10 to 20% of drinkers claim not to experience next-day hangovers. Past studies were usually limited to single timepoint assessments. The aim of the current semi-naturalistic study was to compare the next-day effects of an evening of alcohol consumption of self-reported hangover-resistant drinkers (n = 14) with those of a group of self-reported hangover-sensitive drinkers (n = 15) at hourly timepoint throughout the day (09:30 until 15:30). Assessments of 23 hangover symptoms, mood (Profiles of Mood States-Short Form), and daytime sleepiness (Karolinska Sleepiness Scale) were made hourly after both an alcohol day and an alcohol-free control day. Additional morning assessments were made for mood (State-Trait Anxiety Inventory-Y, Beck's Depression Inventory-II), risk-taking behavior (RT-18), past night sleep (Groningen Sleep Quality Scale), alcohol consumption, and activities during the test days. No significant differences were found regarding the amount of alcohol consumed and the total sleep time of the two groups. The hangover-sensitive group reported having a hangover as well as the presence of a variety of hangover-related symptoms, which were most severe in the morning and then gradually decreased during the day. The most frequently reported and most severe symptoms were sleepiness and fatigue, concentration problems, and headache. In contrast, the hangover-resistant group reported the absence of a hangover and the presence and severity of next-day symptoms did not significantly differ from the control day, except for increased fatigue and reduced vigor. The next-day effects on sleepiness-related complaints and vigor were significantly more pronounced among hangover-sensitive drinkers compared to hangover-resistant drinkers. In conclusion, contrary to hangover-resistant drinkers, hangover-sensitive drinkers report a variety of hangover symptoms that gradually ease during the day, but are still present in the afternoon.

Commentary on Brennan et al.: Pros and cons of minimum unit price for alcohol.

Commentary on Brennan et al.: Pros and cons of minimum unit price for alcohol.

أثر سیاسة تحریر سعر الصرف واختلاف المنطقة الدیموجرافیة على نمط الاستهلاك الغذائى فى مصر

The results of study showed that all food groups except non-alcoholic and alcoholic group, are necessary for consumer, elasticity coefficient ranged between 0.670 for fish group, 0.391 for oils and fats group, and difference in time period (exchange rate liberalization) has a statistically significant impact on average propensity consume, and marginal propensity consume for each cereals and bread, dairy, cheese and eggs, oils and fats, vegetables, sugar and sugary foods, and these groups mostly consider sources of energy food for consumer, except dairy, cheese, eggs, vegetables, which indicate the consumer's tendency to energy food at expense building food (animal protein), perhaps due to changes in real income individual as a result of application policy exchange rate liberalization and its direction for cheaper foods expense building food, which affects negatively on nutritional status for consumer. Also, region (urban, rural) has statistically significant impact on average and marginal propensity of these groups, which may be due to decrease of employment opportunities in rural areas compared to urban, also decrease of agricultural income, which is the main source of income in rural, and consequent difference in the food pattern consumer in rural compared to consumer in urban, and non-provision necessary food needs. Group of food and drink, and other food products not classified under another item, and groups of non-alcoholic and alcoholic drinks, after addition dummy variable to second and third equation showed statistically significant effect of difference in time period that reflects impact of exchange rate policy on these groups

Assessing the association of coffee consumption on the relationship of chronic pain with depression and anxiety

ABSTRACT Background A bidirectional relationship between chronic pain (CP) and mental disorders has been reported, and coffee was believed to be associated with both. However, the association of coffee in this bidirectional relationship remains unclear. We aim to analyze the association of coffee consumption on the relationship of CP with depression and anxiety. Methods A total of 376,813 participants from UK Biobank were included. We collected data on anxiety, depression and CP from objects of our study population. The association of coffee consumption on the relationship of CP with depression and anxiety was assessed through logistic/linear regression models. Moreover, seemingly unrelated estimation test (SUEST) was used to compare whether the coefficients differed in two different groups. Results We observed significant associations of coffee consumption in the interaction of CP with depression and anxiety, such as the association of multisite chronic pain (MCP) on self-reported depression (βcoffee = 0.421, βnon-coffee = 0.488, PSUEST = 0.001), and the association of MCP on generalized anxiety disorder-7 (GAD-7) scores (βcoffee = 0.561, βnon-coffee = 0.678, PSUEST = 0.004) were significantly different between coffee drinking and non-coffee drinking groups. Furthermore, in analysis stratified by gender, we found headache (βmale = 0.392, βfemale = 0.214, PSUEST = 0.022) and hip pain (βmale = 0.480, βfemale = 0.191, PSUEST = 0.021) had significant associations with self-reported depression between males and females groups in coffee drinkers. Conclusions Our results suggested that coffee consumption has a significant association on the relationship of CP with depression and anxiety.