Alaska’s North Slope is especially vulnerable to climatic change because higher latitudes are subject to positive snow- and sea ice-atmosphere feedbacks under warming conditions and because the dynamics of frozen seascapes and landscapes are tightly determined by thermal regime. Shifts in timing and magnitude of freeze–thaw processes are observed to have or expected to have non-linear, threshold-crossing impacts on sea ice, landforms, and biota. Observed changes in North Slope surface air temperatures and precipitation were non-monotonic over the last century, but have trended upward for the last several decades. These changes are linked to hemispheric climate dynamics, reflected in North Pacific and Arctic Oscillation circulation indices. Projected anthropogenic climate changes—with the possibility of continued warming, increased storm frequency and intensity, and decreased insulating snow cover—portend an uncertain future for this domain. Current or foreseen physical system shifts include: (1) declining seasonal and permanent sea ice extent and character, (2) rapid coastal erosion due to storm exposure over a longer near-shore ice-free season, (3) deeper soil active layer over warmer permafrost, along with altered thermokarst processes—contributing to thaw lake expansion, surface drainage re-organization, and hillslope instability. Biogeophysical responses encompass (1) modified surface-atmosphere energy balance from snow cover, vegetation, and hydrologic change and (2) shifted soil and wetland biogeochemical dynamics, including accelerated carbon efflux. Climate-driven plant community shifts on the North Slope result from the interplay of climate, vegetation response, and landscape processes. Some transitions involve stabilizing, others destabilizing plant-permafrost feedbacks. Impacts on caribou, migratory avifauna, and freshwater biota are through direct effects of climate on organism physiology and reproductive biology and indirectly through disruption of habitat mosaics (including along migratory routes) and shifts in competition and trophic linkages. The North Slope’s physical and biological vulnerabilities to shifting climate and observed leading indicators of change are compelling reasons for land managers to consider climatic instability as a threat in conjunction with other known stressors while seeking strategies for protection of this domain’s natural heritage and ecosystem services.