Wireless Capsule Endoscopy is a state-of-the-art technology for medical diagnoses of gastrointestinal diseases. The amount of data produced by an endoscopic capsule camera is huge. These vast amounts of data are not practical to be saved internally due to power consumption and the available size. So, this data must be transmitted wirelessly outside the human body for further processing. The data should be compressed and transmitted efficiently in the domain of power consumption. In this paper, a new approach in the design and implementation of a low complexity, multiplier-less compression algorithm is proposed. Statistical analysis of capsule endoscopy images improved the performance of traditional lossless techniques, like Huffman coding and DPCM coding. Furthermore the Huffman implementation based on simple logic gates and without the use of memory tables increases more the speed and reduce the power consumption of the proposed system. Further analysis and comparison with existing state-of-the-art methods proved that the proposed method has better performance.