Fragment ions produced after the ionization of the acetic acid dimer (CH3COOH)2 in a near-infrared intense femtosecond laser field were measured using time-of-flight mass spectrometry. The two-body Coulomb explosion (CE) process (CH3COOH)22+→2CH3COOH+ with a kinetic energy release of 3.4eV, similar to the case of (HCOOH)22+ (Hoshina et al., 2012), was identified. The two-body CE of (CH3COOH)22+ was induced when the laser polarization direction was perpendicular to the C⋯C intermolecular axis in contrast to the case of (HCOOH)22+. The preferential configurations may be those that deform dimer structures close to dimer dications during the double-ionization process.