This paper discusses the establishment of the biological effectiveness of agricultural products used for sunflower of domestic varieties and foreign hybrids. The scheme of the experiment presented in 20192021 provided for the inclusion in the technology of cultivation of two non-root subcortures of plants with agro-products of various spectrum of action. The paper identifies the most effective agricultural products for their targeted inclusion in the cultivation technologies of specific varieties and hybrids of the sunflower. The most acceptable hybrids of sunflower for cultivation in the Voronezh Region have been selected. Experimental studies were carried out during a three-factor stationary experiment in the field of the Voronezh Federal Agrarian Research Center named after V.V. Dokuchaev. The conducted studies have shown that the Voronezh variety 638 is significantly inferior in its productivity to the hybrids of foreign selection of the Limagrain company (LG5478, LG50270, LG5377). The effectiveness of various agricultural products when used in the cultivation technology of sunflower varieties and hybrids was not the same. Polydon Amino Mix proved to be the best product. The increase in yield from double application with foliar top dressing was 0,80 t/ha. Agro-products Aquadon-Micro (0,58 t/ha) and ZSS (ZSB) 0,41 t/ha were somewhat inferior to Polydon Amino Mix in their effectiveness. The most responsive to agricultural products were hybrids LG5478 and P64LL125.