Event Abstract Back to Event Effects of D1- and D2-Type Dopamine Receptor Blockade on Firing Rate and Synchrony in the Dorsolateral and Dorsomedial Striatum John Burkhardt1* and Rui M. Costa1 1 Instituto Gulbenkian de Ciencia, Portugal Dopamine is known to be essential for the normal function of the dorsal striatum. We have previously shown that dopamine blockade results in alterations in both neuronal firing rate and population synchrony in the dorsal striatum, and these alterations may be partially dissociable into D1-receptor-mediated and D2-receptor- mediated effects, with D1 receptors primarily mediating synchrony and D2 receptors primarily mediating rate. Since D1- and D2-type receptors show an approximately inverse distribution gradient, with D2-type receptors showing the highest concentration in the dorsolateral striatum (DLS) and lowest in the dorsomedial striatum (DMS), we sought to examine whether the rate and synchrony effects resulting from dopamine blockade manifest differentially in these regions. Mice were chronically implanted with multielectrode arrays in the DLS and DMS, and the effects of blocking both D1 and D2 receptor types, or D1 or D2 alone, on spontaneous locomotion, individual neuron firing rate, mean population rate, and synchrony were investigated in striatal medium spiny neurons. Mice were injected intraperitoneally with a D1 antagonist (SCH-23390, 0.4 mg/kg i.p.), a D2 antagonist (raclopride, 2.0 mg/kg i.p.), or both concurrently. All treatments significantly reduced spontaneous locomotion. In vivo recordings were performed for 30 minutes prior to and 60 minutes subsequent to dopamine receptor blockade or saline administration. Firing rate effects were generally similar between DLS and DMS, though there is some suggestion that rate changes in the dorsolateral segment may not be completely dopamine-mediated. Synchrony effects varied in a complex manner between the two regions, and suggested inherent differences in the regions' basal states. These results suggest at least a partial mechanism for some of the functional heterogeneity observed in the dorsal striatum. Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Poster Presentation Citation: Burkhardt J and Costa RM (2009). Effects of D1- and D2-Type Dopamine Receptor Blockade on Firing Rate and Synchrony in the Dorsolateral and Dorsomedial Striatum. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.119 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Aug 2009; Published Online: 11 Aug 2009. * Correspondence: John Burkhardt, Instituto Gulbenkian de Ciencia, Oeiras, Portugal, john.m.burkhardt@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers John Burkhardt Rui M Costa Google John Burkhardt Rui M Costa Google Scholar John Burkhardt Rui M Costa PubMed John Burkhardt Rui M Costa Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.