Indonesia's foreign policy should provide maximum protection to domestic interests, including the MSME sector. MSMEs as the spearhead of the people's economy need to be protected optimally in global trade competition. Indonesia's international trade competition is often defeated by global interests which are suspected of carrying out practices prohibited by international agreements (WTO), so that normally they are sometimes constrained by these agreements. A complex approach is needed to provide a comprehensive view, in this case viewed through the Pancasila economy to ensure and determine the size of domestic interests, so that it has strong arguments in protecting Indonesia's trade interests. This study uses a normative legal method that specifically examines matters relating to legal documents through statutory, conceptual and case approaches. This research has resulted that legal protection has actually been provided by the state through several laws and regulations, but sometimes the arguments for state or domestic interests have not been fulfilled. Foreign policy based on Pancasila as the foundation of the state illustrates that a populist economic system is based on kinship and people's sovereignty to support the improvement of the populist economy.