The present study was conducted on 42 dogs with a histopathological diagnosis of skin neoplasia presented in the Shiraz University Veterinary Clinic from April 2012 to December 2017. All cases were reviewed, excluding the mammary gland neoplasms. The histopathological type, prevalence, sex, age, breed and site distribution of the neoplasms were described. In addition, previous studies on canine skin tumors from other geographic regions were evaluated and compared with the results of the present study. Fifteen different histopathological types of tumor were diagnosed. The prevalence of epithelial, mesenchymal, melanocytic and lymphohistiocytic tumors was 61.9%, 35.7%, 2.4% and 0%, respectively. Th e three most common tumors were sebaceous gland adenoma (21.42%), squamous cell carcinoma (11.9%), and lipoma (11.9%). The incidences of these tumors were more than other researches. Although there is no obvious explanation for these geographical differences, the possible reasons may be the geographical locations, environmental infl uences, and the study population and breed. Terriers were the most common type of the dogs in this study (34.4%). The present findings about the dogs age and various skin tumors and the anatomical locations indicates that there is no signifi cant variation in these important parameters among the Iranian dogs and dogs from other parts of the world.