Doctors Of Other Specialties Research Articles

Hair shaft аbnormalities: a literature review

Hair shaft defects, which are the result of both congenital and acquired pathologies, are usually accompanied by a violation of their physical characteristics and a change in appearance. Hair becomes dull, dry, not elastic, poorly styled, broken. Determining the presence of hair fragility formed the basis for the classification of heterogeneous abnormalities of the hair shaft and their division into two groups.
 The similarity of clinical symptoms and the impossibility of visual verification of the diagnosis dictate the need for additional research methods (dermatoscopy, microscopy, histology), the results of which will help to correctly diagnose. Knowledge of the nuances of the clinical picture, the main dermatoscopic and microscopic markers, the distinctive features of the course of various anomalies of the hair rods expands the capabilities of practicing trichologists, cosmetologists, dermatovenerologists and doctors of other specialties in the field of diagnosis, therapy and prevention of structural hair changes.
 The literature review presents the main clinical, dermatoscopic, microscopic and histological signs of various disorders of hair shafts.

Diagnosis of patients with facial neuropathy by practicing neurologists: online survey

Introduction. Diagnosis of patients with facial neuropathy (FN) is challenging because different sources of medical information off er a wide variety of approaches. Aim. Analysis of the features of diagnosing patients with FN by practicing neurologists. Material and methods. Anonymous online survey of neurologists adhering to the principles of evidence-based medicine (n = 172, work experience — 6 [3; 11] years), including 10 questions. Results. In 56.4% of cases, doctors diagnose patients with FN in accordance with “foreign” guidelines, however, older specialists still prefer Russian sources, and doctors with little work experience prefer the experience of colleagues (p = 0.018). Scales of assessment of facial muscles function are used by 28.5% of specialists, the description method is used by 95.9%. The content of the clinical protocol varies considerably. A highly significant correlation was observed: the lower the muscle is located on the face, the less often its function is assessed (r = –0.938, p < 0.000). Less than 1/3 of doctors use tests to assess the function of the facial muscles of the lower third of the face. Doctors significantly more often focus on the manifestations of the disease (decrease in the strength and tone of facial muscles, lagophthalmos, hyperacusis) than on the complications of FN (increased muscle tone on the healthy or affected side, synkinesis, post-paralytic hemispasm), p < 0.000. Magnetic resonance imaging is prescribed by more than 70% of specialists, computed tomography — by 25%, stimulation electroneuromyography — by 38,4% (in 1/4 of cases only on the affected side of the face). More than 95% of neurologists refer patients for consultations to doctors of other specialties, mainly to an otorhinolaryngologist (58.7%) and an ophthalmologist (56.9%), and only 23.2% to surgical specialists. About 2/3 of doctors refer patients for rehabilitation, however, there is no clinical protocol for the rehabilitation of this pathology. Conclusion. The study showed a greater adherence of the interviewed Russian specialists to evidence-based medicine, as well as a high degree of inter-expert variability of opinions, which dictates the necessity of the development of Russian guidelines.

ПРОФЕССИОНАЛЬНЫЕ НАВЫКИ И ПРОФИЛЬ СПЕЦИАЛИСТА В ОБЛАСТИ МЕДИЦИНСКОЙ МИКРОБИОЛОГИИ (ОБЗОР ЛИТЕРАТУРЫ)

The article discusses the profile and professional skills of a specialist in the field of medical microbiology. The recent trend towards the centralization of microbiological laboratories in order to increase the level of funding, equipment, increase the range of studies performed and to standardize all stages of laboratory diagnostics (preanalytical, analytical and postanalytical) requires a revision of the qualification requirements for medical personnel. The authors raise the issue of a professional standard in the field of medical microbiology and analyze changes in the professional tasks of a medical microbiologist from the period of approval of the first curriculum in medical microbiology to the current stage in the development of laboratory diagnostics of infectious diseases. The basic competencies, obligatory knowledge and skills of a specialist in the field of medical microbiology are discussed, these are necessary for the implementation of job functions in the field of high-technological research methods using the genome of pathogens and microbial communities. The profile of a specialist is considered in terms of interaction with doctors of other specialties for the effective decision of medical problems in antimicrobial therapy and the prevention of infectious diseases. The search for literature sources was carried out using the Scopus, Web of Science, MedLine, Cochrane Library, EMBASE, GlobalHealth, CyberLeninka, and RSCI databases. The study showed that the professional skills of a medical microbiologist should be evaluated together with the specialist’s personal characteristics, which become necessary for graduates’ successful certification in higher medical educational institutions

Медико-социальная характеристика медицинской активности пациентов с болезнями системы кровообращения

INTRODUCTION: The course and outcomes of the disease, including diseases of the circulatory system, are greatly influenced not only by the quality of medical care, but also by the attitude of patients to their health, as well as their medical activity. AIM: To study the age characteristics of the medical activity of patients with diseases of the circulatory system, taking into account gender and marital status. MATERIALS AND METHODS: On the basis of the Vinogradov City Clinical Hospital, Moscow, using a specially designed questionnaire, 582 patients hospitalized in the cardiological and neurological departments of the hospital for diseases of the circulatory system were interviewed. In the mathematical processing of the obtained data, the methods of variation statistics were used. RESULTS: Only 28.9% of the respondents answered that they regularly see a doctor for diseases of the circulatory system. Women were more active than men in terms of compliance with the dispensary observation schedule and the frequency of consultations with doctors of other specialties. According to the data obtained, 62.4% of the respondents considered it necessary to establish schools for the chronically ill and their family members, but only 17.4% of the respondents attended a school for a patient with diseases of the circulatory system. It was found that 86.1% of the surveyed patients with diseases of the circulatory system kept self-monitoring diaries: 68.7 per 100 respondents monitored blood pressure, 46 — blood sugar level and 33.6 — body weight. At the same time, married men are more likely to keep self-monitoring diaries for blood pressure, blood sugar levels and body weight. The timeliness of seeking medical care is the most important criterion that characterizes the medical activity of patients and largely determines the outcome of treatment and the cost of it. The conducted sociological study revealed a rather high medical activity of patients with diseases of the circulatory system, as well as its significant differences in a number of positions in age, gender, and marriage and family aspects. CONCLUSION: The identified features of the self-preserving behavior of patients with diseases of the circulatory system should be taken into account when providing them with therapeutic and preventive care.

СРАВНИТЕЛЬНЫЙ АНАЛИЗ ПРИМЕНЯЕМЫХ МЕТОДОВ ФИЗИОТЕРАПЕВТИЧЕСКОГО ЛЕЧЕНИЯ ГЛОССАЛГИИ

Glossalgia is a chronic disease, the main manifestation of which is pain, characterized by burning and tingling, and, most often, not accompanied by lesions of the oral mucosa and tongue. According to most researchers, the disease is considered polyetiological, as it occurs against the background of concomitant pathologies of various systems and organs, such as damage to the central and peripheral nervous system, disruption of the gastrointestinal tract, endocrine disorders (diabetes mellitus, menopause), diseases of the cardiovascular and circulatory system, as well as the presence of inflammatory and traumatic factors in the oral cavity (traumatization of the oral mucosa by elements of dentures, sharp edges of teeth, dysfunction of the temporomandibular joint). The article is devoted to a comparative analysis of approaches in the treatment of glossalgia by a dentist over the past few years: treatment tactics, what is their effectiveness and what does not lead to positive results with a high proportion of relapses. The topic of glossalgia treatment is relevant, because it is widespread and concerns not only dentists, but also doctors of other specialties: neuropathologists, endocrinologists, therapists, gastroenterologists, psychiatrists. To date, there are many research works of domestic and foreign authors who have devoted their works to this disease. Currently, there are many methods aimed at symptomatic elimination or weakening of paresthesia through medications and instrumental methods of treatment. However, they do not always give a stable therapeutic effect and often their use is accompanied by a number of adverse reactions in the body. The approach to therapy should consist in the complex and systematic use of therapeutic agents, consisting of measures to eliminate pathological foci, medications, physiotherapy, massage, spa treatment of concomitant somatic diseases, compliance with the regime of work and rest and creating a psychologically favorable atmosphere in the environment. To achieve the greatest effectiveness in treatment, the patient should be examined not only by a dentist, but also by doctors of other profiles. In the course of the study, an analysis of the physiotherapeutic methods of treatment of glossalgia was carried out, using tabular and graphic images, in order to identify the most effective treatment tactics within the framework of a dental appointment.

Features of cerebral circulation in patients with chronic migraine

The relevance of differential diagnosis and treatment of primary and secondary headaches remains an important problem for physicians of various specialties. Migraine is a maladaptive disease, which necessitates further study of new pathogenetic mechanisms, symptomatic treatment improvement of migraine, as well as the development of more effective non-drug and drug methods for preventing migraine attacks. It is also important to determine the predictors of the chronic migraine development, which will prevent the episodic migraine transformation into a chronic form. The team of authors conducted a study to assess the degree of cerebral circulatory disorders in patients suffering from chronic migraine. The obtained results of the study made it possible to improve the diagnosis of both chronic and episodic migraine, to clarify the pathogenetic mechanisms of the formation of migraine attacks and the transformation possibility into chronic migraine. Practical recommendations have been developed to improve the effectiveness of ongoing symptomatic and preventive treatment, which improves patient’s quality of life. This article will be useful for doctors – neurologists, algologists, cephalgologists, GPs, doctors of functional and radiation diagnostics and doctors of other specialties, both for beginners and with experience

Chronic and opportunistic infections in patients with immuno-inflammatory rheumatic diseases: screening and prevention issues (based on the materials of the EULAR recommendations)

At the present stage of development of rheumatology, much attention is paid to the problem of comorbid infections, which have a significant impact on mortality and mortality, especially in immuno-inflammatory rheumatic diseases (IIRD). The active introduction into clinical practice of innovative drugs, the action of which is aimed at specific components of the pathogenesis of IIRD, has led to an increase in the risk of developing infections of various nature and localization, including chronic and opportunistic (COI). This article analyzes the recommendations for screening and prevention of COI in adult patients with acute respiratory infections, proposed in November 2022 by experts of the European Alliance of Rheumatology Associations (EULAR). It is noted that these recommendations should be considered through the prism of national guidelines that take into account regional risk factors, features of the course, diagnosis, therapy and prevention of СOI. At the same time, it seems absolutely justified to periodically review screening and preventive procedures as new scientific data accumulate. Despite the importance of a multidisciplinary approach and the need for close cooperation with doctors of other specialties, the EULAR working group emphasizes the central role of a rheumatologist in the management of patients with HOI that occur against the background of IIRD and are associated with the received anti-rheumatic therapy.

Прогнозування перебігу розсіяного склерозу на підставі клінічних особливостей дебюту у пацієнтів Полтавської області

The purpose of the study was to demonstrate the importance of studying variants of the debut of multiple sclerosis, to reveal the dependence of the rate of progression on the clinical picture of the debut of multiple sclerosis by examining patients and retrospective analysis of clinical data. Materials and methods. The study analyzed 60 cases of relapsing-remitting and secondary-progressive multiple sclerosis in patients who were undergoing inpatient treatment in the neurological department of the communal enterprise “M. V. Sklifosovskyi Poltava Regional Clinical Hospital of the Poltava Regional Council” from 2019 to 2021. Complaints, anamnestic data, results of a complex clinical and neurological examination of patients with multiple sclerosis at the onset and throughout the course of the disease were studied. The diagnosis was established according to Mac-Donald criteria. The severity of clinical manifestations was assessed using the Extended Disability Scale. Results and discussion. The rate of disease progression was assessed retrospectively. The ratio of the number of the Extended Disability Scale points at this moment to the duration of the disease in years was studied. In the group of patients with a monosymptomatic debut, the rate of progression was: 0.64 in women, 1.2 in men. In patients with an acute polysymptomatic onset, the values of the rate of progression were 0.7 and 2.1, respectively. As a result of the retrospective analysis, several options for the onset of multiple sclerosis were identified: monosymptomatic, polysymptomatic, patients with a radiologically isolated syndrome, and patients with a characteristic clinical picture, but without pathological changes on magnetic resonance imaging. One of the most frequent clinical manifestations of the debut in patients in the Poltava region was sensitive disorders. It is worth noting that special attention should be paid to the study of vibration sensitivity. When collecting anamnestic data, it is necessary to clarify the presence of Lhermitte syndrome. The rate of progression of multiple sclerosis was found to be higher in male patients with polysymptomatic onset and motor disturbances, between the first symptoms (patient complaints) and the diagnosis of multiple sclerosis from 3 months to several years. Conclusion. The presented research results can be useful for neurologists, general practitioners, radiologists and doctors of other specialties for early diagnosis, prescribing pathogenetic treatment of multiple sclerosis and predicting its course. Prospects for further research are related to the monitoring of clinical observations of multiple sclerosis with the aim of improving diagnostic, therapeutic and rehabilitation measures

Modern aspects of diagnosis and treatment of cognitive impairments (literature review)

Cognitive impairments (CI) are among the most common types of neurological disorders that occur in the practice of both neurologists and doctors of other specialties. The article discusses the modern principles of CI classification according to severity, their clinical signs, diagnostic criteria, and the most important approaches to managing patients with dementia and non-dementia CI. A review of current publications on the treatment of mild CI syndrome (MIS) and dementia was carried out, it was shown that the treatment should be comprehensive and include nondrug methods (regular physical activity, cognitive training), correction of all vascular risk factors, as well as drug treatment aimed at improvement of cognitive functions. At the same time, the strategy for choosing drug therapy for CI is determined by the degree of their severity. The importance of early detection of CI is due to the fact that timely diagnosis of these disorders expands the potential for secondary prevention and therapeutic intervention, which can delay or even prevent the onset of professional and social maladjustment due to the development of dementia. The possibilities of modern neuroprotective and symptomatic therapy of CI, the place of akatinol memantine in the treatment of CI syndrome and dementia are shown. Modern data on the use of this drug in various nosological variants of diseases with MCI syndrome and dementia of varying severity are presented.

Outpatient treatment of pneumonia in a setting with and without an infectious disease doctor

To compare the outpatient treatment of community acquired pneumonia (CAP) by infectious disease doctors (IDDs) and doctors of other specialties (nIDDs). We retrospectively identified 600 outpatients with CAP: 300 treated by IDDs and 300 by nIDDs in two tertiary hospitals during 2019. The two groups were compared in terms of adherence to guidelines, antibiotic group prescription, frequency of combined treatment, and treatment duration. IDDs prescribed significantly more first-line treatment (P<0.001) and alternative treatment (P=0.008). NIDDs prescribed more reasonable (P<0.001) and unnecessary (P=0.002) second-line treatment, and inadequate treatment (P=0.004). IDDs significantly more frequently prescribed amoxicillin (P<0.001) for typical and doxycycline (P=0.045) for atypical CAP, while nIDDs significantly more frequently prescribed amoxicillin-clavulanate (P<0.001) for typical and fluoroquinolones for both typical (P<0.001) and atypical (P<0.001) CAP. No significant differences were found in the frequency of combined treatment, which exceeded 50% in both groups, or in treatment duration. Outpatient treatment of CAP in the absence of IDDs meant more broad-spectrum antibiotic prescription and more disregard for national guidelines. Our results highlight the need for antibiotic stewardship, especially in settings with no IDDs.

A patient with connective tissue dysplasia at a cosmetologist's appointment: features of diagnosis and management

Patients with various manifestations of involutional skin changes often come to an appointment with a cosmetologist and a dermatologist. Among such patients, a group can be distinguished who have premature aging, or rather more pronounced signs of facial aging, in comparison with their peers. Сonnective tissue dysplasia are often found in this group of patients.&#x0D; An example of a patient with connective tissue dysplasia, with multiple organ disorders, with skin manifestations of dysplasia is presented. Tactics of managing such patients, diagnostic features and possible errors in the management of patients with connective tissue dysplasia are analyzed. Particular attention should be paid to the joint management of such patients with doctors of other specialties, respectively, the organ systems involved and recommendations for patients with connective tissue dysplasia regarding lifestyle.

Benigna paroksizmalna poziciona vrtoglavica - put od smernica do svakodnevne kliničke prakse

BPPV is characterized by short periodic episodes of vertigo caused by changes in head position and abnormal stimulation of the cupula of one of the three semicircular canals in the inner ear, most commonly, the posterior. It represents the vertigo that is most often encountered in clinical practice. This narrative review aimed to indicate the latest guidelines and to provide an overview of the most important information related to the timely diagnosis and treatment of patients with this form of vertigo. We discussed the etiology and pathophysiology of the disease, the clinical picture, the paths of making the correct diagnosis, and the most effective types of treatment. A brief overview of the results of the research conducted in our country on the familiarity of clinicians with the guidelines and their application is also given. To avoid late diagnosis, delay in treatment, and additional costs of diagnostic procedures and examinations, it is necessary to formulate a strategy at the national level and constantly educate medical students, general practitioners, as well as doctors of other specialties about this disorder and its treatment methods.

КЛІНІЧНА ФАРМАКОЛОГІЯ: ІСТОРІЯ, СУЧАСНИЙ СТАН ТА ПЕРСПЕКТИВИ

The rapid development of clinical pharmacology took place in the second half of the twentieth century, and it was important that clinical pharmacologists realized the influence of drug metabolism in interpersonal differences in response to drugs; the study of genetically determined features of their pharmacokinetics was started. At present, clinical pharmacology is considered in three main aspects - education, research and health. The question of effective and safe use of drugs is not only before pharmacologists, but also before doctors of other specialties and pharmacists. Technological advances are aimed at the development of patient-centered clinical pharmacology and personalized medicine. It is necessary to integrate the efforts of different fundamental and clinical disciplines to train specialists who will solve the growing problems of multimorbidity and polypharmacy. Among the promising areas are to improve the visibility of the specialty, its clinical and economic value for health care in general and for every citizen.

Myocardial muscular bridge, issues of diagnosis, treatment and medical rehabilitation on the example of a specific clinical case

The myocardial muscular bridge is one of the underes-timated, in clinical practice, congenital anomalies of the coronary arteries, which can have a significant impact on the clinical course, prognosis and outcomes of coronary heart disease, and in some cases can cause sudden car-diac death, including at a young age. The purpose of the article, once again, to draw the attention of practitioners, cardiologists, therapists, general practitioners, doctors of physical rehabilitation medicine and doctors of oth-er specialties to this topic on a specific clinical example. The article summarizes the historical aspects of the topic, diag nostic issues, classification, treatment approaches and features of medical rehabilitation. A clinical case of a patient with a myocardial bridge of HRQ with a char-acteristic clinical picture and reliable instrumental confir-mation was also presented

Modifiable risk factors for the development and progression of periodontal tissue diseases

In this review, an analysis of modifiable risk factors for the development and progression of periodontal tissue diseases was carried out. The review highlights the data on the relationship of periodontal infection, tobacco smoking, diabetes mellitus, cardiovascular disease, drug-induced periodontal tissue damage, stress, and obesity with the risk of developing and progression of periodontal tissue diseases. A rather detailed analysis of the mechanisms of pathogenic influence of the microflora of the oral cavity, including in the subgingival plaque, was carried out. The mechanisms of the pathological effect of smoking on the state of periodontal tissues are described. Data on the effect of periodontal treatment on glycemic control in patients with diabetes mellitus are presented. The article emphasizes the importance of the presence of periodontal diseases as a risk factor for cardiovascular and cerebrovascular diseases, describes the mechanisms of the mutual influence of cardiovascular pathology and the inflammatory process in the periodontium. In addition, the article presents the possibilities of the iatrogenic effect of systemic drugs on the state of periodontal tissues. The data on the influence of stress loads on the development of dental diseases are presented. The review article describes in detail the mechanisms of influence of overweight and obesity on the risks of development and progression of periodontal tissue diseases. Based on the results of the scientific research publications presented in the article, it can be stated that not only the dentist, but also doctors of other specialties need to work to change the modifiable risk factors for the development and progression of periodontal diseases.

A Cross-Sectional Study about Knowledge, Attitude, and Practices among Primary Health Care Physicians in Jazan Province, Saudi Arabia, Regarding Rome IV Criteria for Diagnosis of Irritable Bowel Syndrome.

Background and objectives: Most individuals with irritable bowel syndrome (IBS) are diagnosed by primary health care (PHC) physicians. However, a significant percentage of patients remain undiagnosed or misdiagnosed owing to the lack of knowledge or a systematic strategy regarding the use of ROME IV criteria for the diagnosis of IBS. Thus, in this study, we aimed to assess the knowledge, attitude, and practices among primary health care physicians in Jazan Province, Saudi Arabia, regarding ROME IV criteria for the diagnosis of IBS. Methods: A cross-sectional study was conducted using a pretested self-administered questionnaire that determines participants' sociodemographic data and measures knowledge about ROME IV criteria, targeting PHC physicians in Jazan Province, Saudi Arabia. Data were analyzed using the Statistical Package for Social Sciences (SPSS) v.23. Results: We included 200 participants, and the majority of participants in our study (approximately 78%) were aware of the ROME IV diagnostic criteria for IBS; this awareness was associated with age, nationality, specialty, and classification. The participants' mean level of knowledge was 4.30 (out of 6). However, knowledge was higher among Saudi and family medicine doctors in this study, as compared to non-Saudi and doctors of other specialties. More than two-thirds of participants who were aware of ROME IV criteria thought that they are sufficient to diagnose IBS; however, only 47.5% of physicians reported using ROME IV frequently in their daily practice. Conclusions: Most of the participants of this study are aware of ROME IV criteria, and better knowledge was noted among Saudi and family medicine physicians. About 70% thought that ROME IV criteria are effective enough to diagnose IBS, and only about half of the participants use ROME IV criteria in their practice. Therefore, due to its high prevalence in the region, further efforts are required to disseminate basic knowledge and improve attitudes and practices related to ROME IV criteria among PHC physicians of all specialties.

Clinical and expert assessment of the state of dental prostheses in patients with complaints of intolerance

BACKGROUND: The phenomenon of intolerance to denture structural materials is a multidisciplinary medical issue that necessitates close cooperation between dentists and doctors of other specialties. Criteria for clinical and expert assessment of denture condition are proposed, which will help develop tactics and algorithms for examining patients with intolerance symptoms. Hence, the differential diagnosis of this pathology will be improved, which will increase the effectiveness of dental orthopedic treatment and significantly reduce the number of complaints.&#x0D; AIM: To analyze clinical and expert assessment of denture conditions in patients with complaints of intolerance to dental orthopedic structural materials&#x0D; MATERIAL AND METHODS: We conducted a survey of 486 people with complaints of intolerance at the age of 45 to 89 years with fixed dentures from 2020 to 2022 (174 males and 312 females). All patients, depending on age, were divided into three groups. The denture condition and the time of manufacture were assessed.&#x0D; RESULTS: The examination revealed that the use of dentures ranged from 1 month to 37 years. The analysis of the state of metal-ceramic, ceramic, and prostheses made of zirconium dioxide revealed that orthopedic dental treatment using these structural materials is the most optimal.&#x0D; CONCLUSION: The elderly had the most inconsistent dentures, which is reflected in the number of those who applied with this pathology. Compliance with denture operating conditions and the use of modern structural materials significantly reduces the number of complaints about intolerance phenomena.

АКРОМЕГАЛІЯ: АКТУАЛЬНІ ПРОБЛЕМИ В УКРАЇНІ

In Ukraine, primary diagnosis of orphan diseases is extremely low. In general, this is explained by the insufficient awareness of primary care doctors, the difficulties of diagnosing acromegaly (АМ). The majority of patients seek help at the stage of development of a bright clinical picture of AM. That is why family doctors and doctors of other specialties (therapists, dentists, endocrinologists, neurosurgeons, orthopedists, cardiologists) need to be highly informed in order to suspect and diagnose the disease in time.

OBSERVATION OF A CLINICAL CASE OF TREATMENT OF A PATIENT WITH FILARIASIS

Summary. According to WHO data, about 4.5 million people are affected by parasitic diseases. In the last decade, the attention of clinicians has been drawn to parasitic diseases caused by helminth larvae of animals that are not characteristic of humans. Filariasis is the only transmissible human helminthosis in Ukraine. Despite the fact that there is an opinion that helminthiasis has become “forgotten diseases” in modern conditions, there is a tendency to underestimate their medical and social importance all over the world. In confirmation of the above, the article describes the case of treatment of a patient with filariasis. This clinical example demonstrates that this topic is relevant not only for effectionist doctors, but also for doctors of other specialties. Helminthiasis is often the last point in the chain of differential diagnostic thinking of the doctor. The urgency of the problem is due primarily to the significant prevalence, the pronounced negative impact on the human body, the polymorphism of clinical manifestations, which complicates the differential diagnosis of diseases, the lack of sterile immunity and specific methods of prevention.

ЛЕКАРСТВЕННЫЕ ПОРАЖЕНИЯ ПЕЧЕНИ - СОВРЕМЕННЫЙ ВЗГЛЯД НА АКТУАЛЬНУЮ ПРОБЛЕМУ

Abstract. Introduction. The high prevalence, variability of clinical manifestations, limited knowledge about the mechanisms of toxicity, the complexity of diagnosis makes drug-induced liver injury one of the unsolved problems in clinical medicine. The expansion of the pharmaceutical market, the growth in the number of uncontrolled medications put forward drug-induced liver damage in a number of urgent problems not only for hepatologists, but also for doctors of other specialties. Aim. Review of current scientific publications devoted to the study of drug-induced liver damage. Material and methods. A search and subsequent analysis of scientific publications devoted to the study of the issue of diagnosis and treatment of drug-induced liver lesions, published on the databases: Unpaywall, PubMed, eLibrary, CyberLeninka, MedLine, was carried out. Results and discussion. The article presents up-to-date data on the pathogenesis of occurrence, classification features, principles of diagnosis and treatment of drug-induced liver lesions. Pharmaceuticals that most commonly cause drug-induced liver injury are listed. Conclusion. Drug-induced liver injury covers a wide range of clinical conditions, ranging from mild abnormalities in biochemical parameters to acute liver failure. The vast majority of adverse liver reactions occur from 5-90 days after the last dose of inducer drugs. Many scientific papers have been devoted to the study of drug-induced liver injury, but clinical practitioners still have many unresolved issues related to the correct diagnosis and treatment of drug-induced liver injury. This is facilitated primarily by the uncontrolled prescription and intake of pharmaceuticals, the «fashion» for biologically active additives, which in its outcome forms the development of polypharmacy and, accordingly, the potentiation of hepatotoxicity of drugs.