In order to accelerate the development of advanced manufacturing, promote in-depth integration of the Internet, big data, artificial intelligence and the real economy, and foster new growth areas and new drivers in such areas as high-end and medium consumption, innovation-driven development, green and low-carbon development, sharing economy, modern supply chain and human capital services. Computer Academy of Guangdong, Association of Computing Education in Chinese Universities, and Zhuhai Ton-Bridge Medical Technology together with AEIC Academic Exchange Information Center, hosted the 2021 Guangdong-Hong Kong-Macao Greater Bay Area Artificial Intelligence and Big Data Forum (AIBDF 2021) in Zhuhai, China during September 24 to 26, 2021.This conference focused on artificial intelligence, big data and medical and big health AI science, aimed to provide a platform for experts and scholars, engineers and researchers to share scientific research results and cutting-edge technologies, understand academic development trends, broaden research ideas, strengthen academic research and discussion, and promote cooperation in the industrialization of academic achievements.About 300 participants from academic, high-education institutes and other organizations took part in the conference. The conference model was divided into two sessions, including oral presentations and keynote speeches. In the first part, some scholars, whose submissions were selected as the excellent papers, were given 15 minutes to perform their oral presentations one by one. Then in the second part, keynote speakers were each allocated 30-45 minutes to hold their speeches. We were very honored to have Prof. Guoqiang Han, from South China University of Technology as our Conference Chairman.In the keynote presentation part, we invited 16 professors as our keynote speakers. The first keynote speaker, Prof. Junlong Chen, Distinguished Chair Professor, Doctoral Supervisor, Dean of School of Computer Science and Engineering, from South University of Technology. The others keynote speakers as follow: Prof. Guoliang Chen, Parallel algorithms, high performance computing experts; Prof. Anhui Liang, the director of the interdisciplinary research center of optical fiber communication and bio-optics, Shandong University of Science and Technology; Prof. Weijia Jia, from International College of Beijing Normal University-Hong Kong Baptist University; Prof. Zhengtian Fang, from La Trobe University in Australia; Prof. Yutong Lu, from Sun Yat-sen University; Prof. Young Liang, from Macau University of Science and Technology; Prof. Nong Xiao, from Sun Yat-sen University; Prof. Xiaofeng Zhu, from University of Electronic Science and Technology of China; Prof. Jianxin Wang, from Central South University; Prof. Xuan Wang, from Harbin Institute of Technology institute; Prof. Guoqiang Zhong, a member of ACM, IEEE, IAPR and China computer society; Prof. Bing Shi, a member of IEEE, ACM and CCF; Assoc. Prof. Chunjiang Duanmu, from Zhejiang Normal University; Prof. Yang Yue, from Nankai University; Prof. Na Li, from Xi’dian University.The proceedings present a selection of high-quality papers submitted to the conference by researchers from universities, research institutes, and industry. All papers were subjected to peer-review by conference committee members and international reviewers. The papers were selected based on their quality and their relevance to the conference. The proceedings present recent advances in the fields of Direction of Big data, Direction of Artificial Intelligence, Direction of Medical and health care and others related research.I would like to express special gratitude to members of the conference committee and organizers of the conference. I would also like to thank the reviewers for their valuable time and advice which helped in improving the quality of the papers selected for presentation at the conference and for publication in the proceedings. Finally, I want to thank the authors, the members of the organizing committee, the reviewers, the chairpersons, sponsors, and all other conference participants for their support of AIBDF 2021.The Committee of AIBDF 2021List of Committee member are available in this pdf.