Aims: The cough affects adversely the comfort of patient and process during fiberoptic bronchoscopy. Various studies have been made to prevent cough during bronchoscopy. However, there is no any medication that usage of it becomes definite. The influence of usage codeine in bronchoscopy premedication in addition to the midazolam on the comfort of patient and physicians is examined. Methods: 96 patients made bronchoscopy for various indications were included to the study. The study was carried out as a prospective, placebo-controlled and double-blind. The patients were divided into two groups. Group 1 (n = 48) 20 mg fenocodeine tablets divided into 4 doses were administered one day before process. Group 2 (n = 48) the placebo tablets divided four dose were administered one day before process. Both of two groups were administered midazolam before procedure. Topical anesthesia was administered as needed during the operation and its doses were recorded. Two questionnaire form that examined the level of comfort of patients and physicians, the amount of secretion and the severity of cough with a visual analogue scale (VAS) were prepared and they were immediately completed after procedure. Results: In both groups, any complication wasn’t occurred that require to terminate the process. In the scala evaluated by patients given fenocodein, the amount of cough was statistically significantly low (p = 0.026). In the scale evaluated by doctors, the amount of secretion was lower (p = 0.02). Comfort level of doctor was found significantly higher in Group 2 (p = 0.02). Conclusion: It was determined that the amount of secretion and cough had decreased and the level of comfort had increased when fenocodeine was given with midazolam prior to bronchoscopy