You have accessJournal of UrologyInfertility: Epidemiology & Evaluation I (MP21)1 Sep 2021MP21-18 IT'S NOT ABOUT TIME: DOES ABSTINENCE ALTER SEMINAL OXIDATIVE STRESS OR DNA FRAGMENTATION RATES? Kevin Campbell, John Sullivan, Oscar Velazquez, and Larry Lipshultz Kevin CampbellKevin Campbell More articles by this author , John SullivanJohn Sullivan More articles by this author , Oscar VelazquezOscar Velazquez More articles by this author , and Larry LipshultzLarry Lipshultz More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002006.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Seminal oxidative stress and DNA fragmentation have been associated with male infertility, poor embryo development, and recurrent miscarriage. Oxidative stress can be measured using the static oxidation-reduction potential (ORP) as well as chemiluminescence assays for reactive oxygen species (ROS). Studies have independently shown ORP and ROS values to be respectively increased in semen samples of abnormal quality compared to those of normal samples. Additionally, semen parameters have been shown to change reflecting the number of days of abstinence (DOA) prior to a patient providing a semen sample. Since many fertility patients travel a long distance or are not counseled about the number of days abstinence before collecting, we designed this study to evaluate the relationship between number of days of abstinence, oxidative stress, DNA fragmentation, and age of patients. METHODS: Semen samples from a high-volume men’s fertility clinic were retrospectively evaluated for DOA, DNA fragmentation, and oxidative stress quantified by ROS or ORP. DOA samples were then stratified by DNA damage percentage and ROS/ORP for association. RESULTS: A total of 857 semen samples were identified by those with patient DOA, including 818 with ROS values, 199 with ORP, and 857 with DNA damage testing. DOA showed no significant correlation when stratified by ROS (R2=0.003, p=0.4523), ORP (R2=0.001, p 0.595), or DNA damage (R2=0.001, p=0.461). CONCLUSIONS: A patient’s DOA prior to providing a semen sample does not correlate with DNA damage percentage or oxidative stress measured by ORP or ROS. Therefore, these more analytically complicated tests may be done at any visit, regardless of the day’s abstinence. Consequently, these results can be ready for the patient’s subsequent visit, at which time a DOA controlled sample can be obtained for better determination of abstinence-related sperm density and motility. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e353-e353 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kevin Campbell More articles by this author John Sullivan More articles by this author Oscar Velazquez More articles by this author Larry Lipshultz More articles by this author Expand All Advertisement Loading ...