15126 Background: Chemotherapy significantly improves survival in comparison to best supportive care in patients with metastatic gastric cancer. In patients for whom a three-drug-combination is considered as the treatment of choice, ECF (epirubicin, cisplatin and 5-FU as a continuous infusion) should be regarded as standard of care. Continuous 5-FU infusion may be replaced by oral fluoropyrimidines. Here, we aimed to evaluate treatment with epirubicin and cisplatin combined with oral UFT with leucovorin (ECU), replacing intravenous 5-FU infusion Methods: Fifty-three patients (17 female, 36 male) with metastatic gastric carcinoma received epirubicin, cisplatin, and oral UFT plus leucovorin in two outpatient chemotherapy clinics, in Istanbul. Epirubicin 50 mg/m2 and cisplatin 60 mg/m2 were administered on day 1; and UFT 300 mg/m2/day was administered in conjunction with oral calcium folinate at a fixed dose of either 45 or 90 mg/day in divided daily doses for 21 days continuously. The treatment was repeated every 3 weeks. The patients were evaluated radiologically for response after each three-cycle period. Age, gender, ECOG performance score (PS), primary cancer localization, and presence of primary curative surgery were analyzed for prognostic factors. Results: Median follow-up was 6 (range 1–12) months. Median age was 57 years (range 27–76). Patients received a median of three courses of treatment (range: 1–6). Over 86% of the patients had PS =1, whereas remaining 13% had PS 2. Forty-three percent of the patients were undergone curative surgery at the time of cancer diagnosis, while 57% presented as metastatic disease. The most frequent site of metastases was liver (42%). Twenty-five percent of the patients showed partial responses, while none showed a complete response. Over 28% of the patients had stable disease resulting in a tumor control rate of 53%, and 47% had progressive disease. Median TTP and OS were 6 and 8.6 months, respectively. In univariate analysis; having PS =1, and presence of primary curative surgery were independent prognostic factors (p:0.042, and p:0.019, respectively) Conclusion: ECU regimen has a significant activity in metastatic gastric cancer. It does not require an infusion pump and intravenous catheter. No significant financial relationships to disclose.