Diversification Opportunities Research Articles

Morphological characterization of shallot (Allium cepa L. var. aggregatum) segregating populations obtained from natural-outcrossing in Ethiopial-outcrossing in Ethiopia

Shallot is a vegetable and condiment crop widely used in Ethiopia and globally. However, absence of improved and adaptable varieties has been the major cause of low productivity. Narrow genetic base of local shallot germplasm owing to vegetative reproduction of the crop, among others, has been the root cause of low productivity. Nevertheless, some plants within the germplasm were observed bolting and producing viable seeds, presenting an opportunity for genetic diversification. Consequently, a germplasm enhancement program was initiated using these naturally outcrossing genotypes where about eighty-one genotypes were generated. The present study was thus undertaken with the objective of characterizing, classifying, and selecting the eighty-one genotypes for future breeding activities. The genotypes were planted in 9x9 simple lattice design with two replications at Debre Zeit Agricultural Research Center (Ethiopia) during the dry (irrigated) season of 2021. The genotypes were evaluated for fifteen growth, yield, and quality traits. Significant variations were observed among the genotypes in terms of bulb yield, bulb height and diameter, total soluble solids, bolting percentage, and bulb skin color. Bulb yield of the genotypes ranged from 31.33 t/ha in DZSHT-79-1A to 9.63 t//ha in DZSHT-45-1A-1. DZSHT-51-2 (207.93 g) was the highest yielder per plant whereas DZSHT-065-6/90 (74.51 g) was the lowest yielder. DZSHT-14-2-1/90 had the thickest bulb (44.69 mm) significantly thicker than twenty two genotypes which had bulb diameter ranging from 28.92 mm to 20.29 mm. DZSHT-81-1/90 was a genotype with the longest bulb height (52.33 mm) while DZSHT-147-1C was a genotype with the shortest bulb (33.12 mm). DZSHT-307-1/90 had the highest TSS (16.78°Brix) significantly differing from DZSHT-002/07 which had the lowest TSS (11.17 °Brix). Dry matter of the genotypes ranged from 12.00% to 22.79%. DZSHT-004/07, DZSHT-111-2-1, DZSHT-41-2B and DZSHT-72-2 had DM% greater than 20% which coupled with greater than 14 °Brix could make them suitable for dehydrated shallots. Among the 81 genotypes characterized 4 (4.9%), 7 (8.6%), 13 (16.1%), 28 (34.6%) and 29 (35.8%) were yellow, golden, light red, red and dark red in colour, respectively. Fifteen of the genotypes had at least 50% bolting plants whereas twenty nine of the genotypes had less than 25% bolting. The results revealed that seven principal components explained approximately 76% of the observed variation. Cluster analysis grouped the genotypes into seven clusters, with the majority falling into three clusters. The study successfully identified genotypes with diverse and important traits and availed both the genotypes and the information for future breeding programs. These genotypes could be used for the development of improved hybrid and open pollinated shallot varieties with higher yield, quality and pest resistance/tolerance attributes.

Machine learning-based uncertainty analysis in power system planning: Insights and pathways for decarbonization

This study performs an extensive uncertainty analysis of decarbonization pathways for the Canadian power system. By leveraging machine learning (ML) techniques, we represent complexities and nonlinear behaviors of the power system, which are challenging to observe using traditional modeling methods due to computational limitations. We further utilize K-means clustering and statistical methods to identify correlations, investigate the effects of uncertainty in key parameters (capital costs, demand, and carbon tax), and identify opportunities for diversification of the power generation mix. Key findings include the increased flexibility of gas combined cycle (generation mean 4.8 TWh, installed capacity mean 4.8 GW) over gas simple cycle (generation mean 22.3 GWh, 0 installed capacity) in response to carbon tax, highlighting its role in a low-carbon future. Variations in solar and wind deployment rates, influenced by capacity factors and location-specific costs, underscore the necessity of a flexible grid system. This analysis reveals important correlations between renewable deployment, and transmission expansion and gas combined cycle reliance. The results also highlight minimal sensitivity of hydroelectric power generation (∼ 43 % of scenarios) to changes in input parameters. The novelty of our work lies in proposing a comprehensive approach which uses ML techniques to go beyond the capabilities of existing models, specifically by performing extensive uncertainty analysis and provides key insights into system behavior, causative factors, and an expanded breadth of potential pathways. Taken together, this proposed approach lays a foundation for strategic planning and policy formulation.

Reverting Woodlots to Crop Fields in the Southern Highlands of Tanzania

For some decades, woodlots have been a salient feature of the agricultural landscapes of Mount Rungwe and Uporoto Highlands in the Southern Highlands of Tanzania. Their proliferation amidst socioeconomic conditions and innovation in farming practices influence production choices, and consequently, land use changes. Recently, farmers are reverting prevailing woodlots into crop fields, particularly, Irish potatoes. We investigate this process in order to examine the determinants of the reversion and the implications to agricultural development and people’s livelihoods. The findings come from a survey of smallholders of woodlots in four villages around Mount Rungwe and Uporoto Highlands. Data were collected through structured and in-depth interviews, discussions with focused groups at village levels, review of documents and direct field observation. Time lag for woodlots, safeguarding households’ food security, lack of agricultural support services, high rental market, and emergence of other fruit trees are determinants of the reversion. The reversion has implications for farmers’ decreased access to reliable source of fuelwood as well as opportunity for livelihood diversification.

Portfolio diversification opportunities in traditional energy and alternative/renewable energy ETF segments

"This study evaluates the diversification benefits of investing in traditional and alternative/renewable energy Exchange Traded Funds (ETFs) using the VAR-ADCC-GARCH model to analyze yields, correlations, and volatilities. The results demonstrate that alternative/renewable energy ETFs not only offer higher average returns but also significantly reduce portfolio risk compared to traditional energy ETFs. The research underscores the distinct investment dynamics between the two ETF segments, highlighting the advantages of incorporating renewable energy assets into diversified portfolios. These findings support the inclusion of environmentally-conscious investment strategies that effectively balance risk and return, emphasizing their importance for investors aiming to optimize their portfolios in line with sustainable practices. Keywords: portfolio diversification, ETFs, traditional energy, renewable energy, VAR-ADCC-GARCH Model JEL classification: G11, C58, A100, A110"

Does CEA or EUA matter for major commodity markets? Fresh evidence from the analysis of information spillovers and portfolio diversification

PurposeThis study conducts a comparative analysis of the diversification effects of China's national carbon market (CEA) and the EU ETS Phase IV (EUA) within major commodity markets.Design/methodology/approachThe study employs the TVP-VAR extension of the spillover index framework to scrutinize the information spillovers among the energy, agriculture, metal, and carbon markets. Subsequently, the study explores practical applications of these findings, emphasizing how investors can harness insights from information spillovers to refine their investment strategies.FindingsFirst, the CEA provide ample opportunities for portfolio diversification between the energy, agriculture, and metal markets, a desirable feature that the EUA does not possess. Second, a portfolio comprising exclusively energy and carbon assets often exhibits the highest Sharpe ratio. Nevertheless, the inclusion of agricultural and metal commodities in a carbon-oriented portfolio may potentially compromise its performance. Finally, our results underscore the pronounced advantage of minimum spillover portfolios; particularly those that designed minimize net pairwise volatility spillover, in the context of China's national carbon market.Originality/valueThis study addresses the previously unexplored intersection of information spillovers and portfolio diversification in major commodity markets, with an emphasis on the role of CEA.

“Safer to plant corn and beans”? Navigating the challenges and opportunities of agricultural diversification in the U.S. Corn Belt

AbstractAgricultural diversification in the Midwestern Corn Belt has the potential to improve socioeconomic and environmental outcomes by buffering farmers from environmental and economic shocks and improving soil, water, and air quality. However, complex barriers related to agricultural markets, individual behavior, social norms, and government policy constrain diversification in this region. This study examines farmer perspectives regarding the challenges and opportunities for both corn and soybean production and agricultural diversification strategies. We analyze data from 20 focus groups with 100 participants conducted in Indiana, Illinois, and Iowa through a combined inductive and deductive approach, drawing upon interpretive grounded theory. Our results suggest that when identifying challenges and opportunities, participants center economics and market considerations, particularly income, productivity, and market access. These themes are emphasized both as benefits of the current corn-soybean system, as well as challenges for diversification. Additionally, logistical, resource and behavioral hurdles– including the comparative difficulty and time required to diversify, and constraints in accessing land, labor, and technical support– are emphasized by participants as key barriers to diversification. Agricultural policies shape these challenges, enhancing the comparative advantage and decreasing the risk of producing corn and soybeans as compared to diversified products. Meanwhile, alternative marketing arrangements, farmer networks, family relationships, and improved soil health are highlighted as important opportunities for diversification. We contextualize our findings within the theories of reasoned action and diffusion of innovation, and explore their implications for farmer engagement, markets, and agricultural policy, and the development of additional resources for business and technical support.

Do rotations and intercrops matter? Opportunities for intensification and diversification of maize-based cropping systems in Zambia

ContextRealizing the double-edged goals of food security and crop diversification require knowledge of crop yield response to different agricultural practices and the extent to which such response is context dependent. This is particularly important in Southern Africa where cropping systems are dominated by maize and smallholders use few external inputs. ObjectiveThe objectives of this study were (1) to evaluate the performance of cropping systems with different levels of legume diversification and intensification on maize productivity across the main agroecological zones and farming systems of Zambia, and (2) to establish the minimum land required to reach maize self-sufficiency at household level with the different cropping systems tested. MethodsSix maize-based cropping systems, comprising maize monocropping, maize-legume rotations and intercrops under ‘conventional’ tillage and conservation agriculture, were evaluated across 40 farms in contrasting agro-ecological zones and farming systems of Zambia. A household survey was conducted in the same communities hosting the on-farm trials to quantify the share of households with enough maize cultivated area to benefit from the tested cropping systems. ResultsMaize yield measured in the on-farm trials ranged, on average, between 3.6 and 5.4 t ha−1, which was greater than mean maize yields reported by farmers not hosting on-farm trials during the same growing seasons and in the same sites. Our results showed a clear positive effect of legume rotation on maize yield in Eastern province only, where cropping systems including groundnut as rotation crop yielded between 1.0 and 2.0 t ha−1 more maize than other cropping systems. Pigeon pea intercrops and Gliricidia hedgerows, crop residue management, and tillage practice had no significant effect on maize yield in any of the provinces. Finally, nearly 35, 50, and 70% of surveyed farms in Northern, Eastern, and Southern province would have enough land to achieve the same level of maize production obtained on their farm with the yields, and associated area requirements, of the maize-legume rotations tested in the on-farm trials. ConclusionLegume rotations can increase maize productivity on land abundant farms in high potential maize production areas of Southern Africa, whereas legume intercrops have benefits at cropping systems level and should be targeted to land constrained farms. SignificanceThe study contributes to better understand the niche for diversified maize-based cropping systems with legume rotations and intercrops in Southern Africa, along with their impacts on maize productivity at the field level and their land requirements at the farm level.

International Portfolio Diversification Benefits: An Empirical Investigation of the 28 European Stock Markets During the Period 2014–2024

Abstract This study investigates the benefits of international diversification in the stock markets of the 28 European countries (the EU and the UK) over two five-year periods: a stable period from 2014 to 2019 and a turbulent period from 2019 to 2024. The analysis draws on the Markowitz mean-variance, Sharpe reward-to-variability, and naive diversification models, based on which different investment strategies were developed and implemented. We find that actively managed portfolios perform significantly better than naively diversified portfolios. The analyzed markets exhibit positive short-term associations, with an average correlation coefficient of 0.29 in the first period and 0.46 in the second period. However, these markets do not show long-term cointegration. Recent crises have reduced diversification benefits, yet significant opportunities for diversification remain. Diversification benefits are almost halved in the second period: average single-market standard deviation can be reduced by 60.5% with investments in 20-indices portfolios in the stable period, and only by 33.7% with the same portfolio size in the turbulent period.

Volatility Spillover from the Chinese Stock Market to the G20 Stock Markets in the Wake of the Pandemic COVID-19

We analyze the volatility spillover effect from the Chinese stock market to different stock markets in the G20 countries. We employ dynamic conditional correlation and vector autoregression (VAR) to analyze adjusted daily closing stock indices extending from 1st October 2019 to 30th June 2020. The result reveals that there is short-run volatility in sample stock return except Australia and South Korea. Similarly, there is long-term volatility persistence in sample countries’ stock exchange except Australia, Saudi Arabia, Russia, and France. However, Australia is only the country where there is no short- and long-run information transmission derived from China. Therefore, there is a portfolio diversification opportunity in this country during COVID-19. Overall, this paper shows significant interdependencies between the Chinese and the G20 markets which furnish momentous implications to the stakeholders of markets.

Asymmetric connectedness and investment strategies between commodities and Islamic banks: Evidence from gulf cooperative council (GCC) markets

The study uses the data of thirteen Islamic Banks (IB) in the GCC region and sixteen commodities that include soft agriculture, energy, industry, and precious metal commodities. Murabaha transactions makes up most of the revenues of the Islamic banks, whereas commodities set up the biggest portion of the assets among Murabaha transactions, therefore commodities and IB revenues are expected to comove. Interestingly, empirical findings suggest that most of the Islamic banks and commodities are not significantly affected by the shocks from other markets. We further observe that negative shocks have a higher impact on market connectedness among used assets compared to the positive returns and find a significant role of risk variables in explaining the magnitude of spillover between used assets. We perform robustness of our results in sub-samples periods during Shale Oil Revolution, Global Financial Crisis, and the COVID-19. Additionally, the multivariate portfolio analysis shows some risk reduction properties of the majority of the used assets. The performance evaluation measures demonstrate that weights selected based on dynamic connectedness network presents diversification opportunities. These findings help investors and portfolio managers to remain alert to the movements of the risk factors and calibrate there hedging and portfolio management strategies by taking long and short positions as incorporation of Islamic banks and commodities in the GCC region in a portfolio could yield risk reduction benefits and profitability.

Is there a time-varying nexus between stock market liquidity and informational efficiency? – A cross-regional evidence

PurposeThis study aims to measure the degree of volatility comovement between stock market liquidity and informational efficiency across Asia, Europe, North-South America, Africa, and the Pacific Ocean over three decades. In particular, the authors analyze the extent of the time-varying nexus between different aspects of stock market liquidity and multifractal scaling properties of the stock return series across various regions and diversified market conditions. This study further investigates several factors altering the degree of dynamic conditional correlations (DCCs) between the efficiency and liquidity of the domestic stock markets.Design/methodology/approachThe study measures five aspects of stock market liquidity – tightness, depth, breadth, immediacy, and adjusted immediacy. The authors evaluate the multifractal scaling properties of the stock return series to measure the level of stock market efficiency across the regions and diversified market conditions. The study uses the dynamic conditional correlation-multivariate generalized autoregressive conditional heteroscedasticity framework to quantify the degree of volatility comovement between liquidity and efficiency over the period.FindingsThe study finds the presence of stronger volatility comovement between inefficiency and illiquidity due to the price impact characteristics of the stock markets irrespective of different regions and diversified market conditions. The extent of time-variation increased following the shock periods, indicating the significant role of the financial crisis in increasing the volatility comovement between inefficiency and illiquidity. The highest degree of time-varying correlation is observed in the developed stock markets of Northwestern and Northern Europe compared to the regional and emerging counterparts. On the other hand, weak DCCs are observed in the emerging stock markets of Europe.Originality/valueThe output of the present study assists investors in identifying diversification opportunities across the regions. Additionally, the study has significant implications for market regulators, aiding in predicting future troughs and peaks. The prediction, in turn, helps formulate capital market development plans during dynamic economic situations.

Do socially responsible indices outperform conventional indices? Evidence from before and after the onset of Covid‐19

AbstractAccording to traditional portfolio theories constraints, restrictions, and screens applied in portfolio selection reduces the diversification opportunities which can impact financial performance. Is this true in the case of socially responsible investment (SRI)? To answer this, present study analyzes the performance of Socially Responsible (SR) indices in comparison to conventional indices in an emerging economy. The uniqueness of the study is that it analyses the performance of Shariah, ESG, and thematic indices in a single study. Further, the study measures the impact of Covid‐19 on them. Comparative performance evaluation was conducted by using absolute return analysis and risk‐adjusted measures namely, Sharpe ratio, Treynor ratio, tracking error, information ratio, capital asset pricing model (CAPM), Fama–French three‐factor, and Carhart's four‐factor models. The Structural break was identified, hence analysis was conducted for the total period (January 2017–March 2023) and two sub‐periods, that is, pre and post‐Covid‐19 period. No significant difference was found between the returns of SR indices and conventional indices as against the benchmark index on the basis of absolute return analysis. Sharpe ratio and Treynor ratio both were having negative values for all the SR and conventional indices. Tracking error for all the SR and Conventional indices were very low. The CAPM and both multi‐factor models univocally pointed toward the underperformance of all the SR (except S&P BSE 100 ESG index which had equal performance) and both conventional indices against the benchmark index. Noteworthy point is that only Shariah indices gave the highest returns during post‐Covid period. This research will help in deepening the SRI in the capital market. Companies should increase their ESG scores and make efforts to be listed on the SR indices. Policymakers should announce some kind of rebates, or recognition for star‐performing companies in the field of sustainability to encourage other companies to adopt SR practices in their business operations. The novelty of the current study is that it adds to the socially responsible literature by analyzing the performance of Shariah, ESG, and Thematic indices and conventional indices in a single study in the fastest‐growing economy of India and analyses the impact of Covid‐19 on this performance.

Challenges and Opportunities of Livelihood Diversification in Ethiopia: A Review Article

Diversifying sources of income has been recognized as a crucial approach to alleviate poverty, mitigate food insecurity, and enhance the overall well-being of rural residents in Ethiopia. This review outlines the key challenges and opportunities associated with livelihood diversification in the country. The study identifies several primary constraints that hinder livelihood diversification, including inadequate infrastructure development, scarcity of arable land, limited access to credit services, gender disparities, and poor rural-urban linkages. However, it also highlights potential avenues for sustainable livelihoods through diversification, such as the promotion of sustainable land management practices, adoption of climate-resilient agricultural strategies, and the provision of training and capacity building programs. To facilitate successful livelihood diversification, the review emphasizes the urgency of investing in infrastructure development and ensuring access to credit services. Moreover, it underscores the importance of promoting gender equality to mitigate the challenges faced by women in diversifying their livelihoods. Encouraging sustainable land management practices, implementing climate-resilient agricultural strategies, and providing comprehensive training and capacity building programs are identified as critical measures to support diversification efforts in Ethiopia effectively. The review offers evidence-based policy recommendations to inform government agencies, non-governmental organizations (NGOs), and other stakeholders on effective strategies that can enhance livelihood diversification in the country, while also ensuring inclusivity and sustainability. The significance of livelihood diversification within Ethiopia's development agenda cannot be overstated, and it is imperative for stakeholders to act in addressing the identified challenges and capitalizing on the opportunities presented by diversification. By doing so, they can contribute to poverty reduction and sustainable development in the country. However, it is essential to note that further research is necessary to explore the efficacy of livelihood diversification strategies in different contexts and identify additional opportunities and challenges that may arise.

Estimating growout production costs of commercial‐scale marine finfish production in southern tier US states

AbstractIncreased interest in marine fish farming in the United States has led to a need for fundamental economic information on production of candidate species for commercialization in various production systems. Funding for the project targeted those species with potential for production in southern tier states in the United States. Sufficient technical data were found to develop comprehensive budget analyses to estimate growout production costs for four scales of production for each of 10 species with potential for production in ponds, 13 in recirculating aquaculture systems (RAS), and five in net pens. The choice of species/production system scenarios was based on evidence of successful production on farms or in research. Estimation of production costs with enterprise budgets can provide useful guidance to identify the types of improved efficiencies that have the greatest effect on economic viability even when commercial farm data are not available. Commercial farm data were used where available, but for most species, data were available only from studies conducted under research conditions. Per‐kg costs of production were lowest for net pen production, followed by ponds, with production costs in RAS two to five times greater than in ponds or net pens. Ponds and net pens generally exhibited greater efficiency of use of capital assets across species than did RAS that resulted in lower percentages of fixed costs and lower annual costs per kg of fish produced. All five species evaluated for net pen production were estimated to be profitable, including redfish, Sciaenops ocellatus (also known as red drum), striped bass, Morone saxatilis, cobia, Rachycentron canadum, red snapper, Lutjanus campechanus, and seriolids (generic budget for almaco jack, Seriola rivoliana, California yellowtail, Seriola lalandi, and greater amberjack, Seriola dumerili), four in ponds (redfish, hybrid drum, ♀Pogonias cromis × ♂Sciaenops ocellatus, black sea bass, Centropristis striata, and cobia), but none of the RAS scenarios showed profitability at average yields (kg/cubic meter) reported in the literature. Comprehensive data on growout production of marine finfish species in the United States is generally lacking, and there is a strong need for production trials conducted under near‐commercial conditions with an endpoint of market‐sized fish. Production trials should be conducted in ponds (≥0.1 ha), net pens, and RAS tanks of a size that simulate commercial production conditions. Adequate production trial databases would provide opportunities to develop economic optimization models that would provide useful guidance for prospective producers. Average yields (kg/cubic meter) in RAS will need to be much greater than currently reported in the research literature for RAS production to be economically sustainable. Net pen production appears to be profitable in the United States, but effective permitting procedures are not in place. Providing research support for the US redfish sector that has developed effective production and marketing models could serve as a foundation for developing additional species and offer opportunities for diversification on marine finfish farms.

Energy transition and sustainable development in Malaysia: Steering towards a greener future

In the evolving landscape of global energy dynamics, Malaysia stands as a pivotal example of a nation actively transitioning towards renewable energy and sustainable development. This paper provides a comprehensive analysis of Malaysia's energy sector transformation, underpinned by the government's commitment to reducing carbon emissions and mitigating the impacts of climate change. The objective of this research is to delve into the intricacies, opportunities, and challenges of steering Malaysia towards a greener future, with a particular focus on the shift from reliance on fossil fuels to the adoption of renewable energy sources such as solar, wind, and biomass. Employing a mixed-method approach, this study synthesizes existing literature, policy documents, and case studies to examine the current state and historical context of energy use in Malaysia, analyze government initiatives and policy frameworks, explore technological advancements, and assess the environmental and socioeconomic impacts of the energy transition. Results indicate that despite facing challenges such as financial investment, technological advancement, and public acceptance, collaborative efforts between the government, private sector, and communities have led to significant progress in promoting renewable energy. The paper concludes that Malaysia's energy transition represents a critical step towards achieving a balance between economic growth and environmental preservation, setting a precedent for sustainable development in the Southeast Asian region. This transition is not only essential for climate change mitigation but also presents opportunities for economic diversification, energy security, and social inclusivity. The study ultimately calls for continued innovation, supportive policies, and international cooperation to overcome remaining barriers and fully realize the potential of renewable energy in Malaysia.

Valorization of cocoa pod side streams improves nutritional and sustainability aspects of chocolate

Chocolate production faces nutritional, environmental and socio-economic challenges present in the conventional cocoa value chain. Here we developed an approach that addresses these challenges by repurposing the often-discarded pectin-rich cocoa pod endocarp and converting it into a gel. This is done using cocoa pulp juice concentrate to replace traditional sugar from sugar beets. Although swelling of fibres, proteins and starches can limit gel incorporation, our proposed chocolate formulation contains up to 20 wt% gel. It also has comparable sweet taste as traditional chocolate while offering improved nutritional value with higher fibre and reduced saturated fatty acid content. A cradle-to-factory life cycle assessment shows that large-scale production of this chocolate could reduce land use and global warming potential compared with average European dark chocolate production. The process also provides opportunities for diversification of farmers’ income and technology transfer, offering potential socio-economic benefits for cocoa-producing regions.

Evaluating the Efficiency of Alternative Investment Vehicles in Modern Portfolio

Abstract: The evolving global economic landscape has prompted investors to diversify their portfolios beyond traditional stocks and bonds, leading to the increasing prominence of alternative investments. This study examines the role and effectiveness of alternative investment options, such as private equity, hedge funds, real estate, and commodities, in modern investment portfolios. These non-traditional assets offer unique opportunities for risk management, diversification, and potential growth, making them appealing choices for investors seeking to enhance their portfolio's performance and stability. The research highlights the key factors driving the growing appeal of alternative investments, including their ability to provide diversification benefits by spreading risk across a range of assets with low correlation to traditional market indices. Additionally, these investments present opportunities for increased returns, particularly in low-interest rate environments, and enable investors to access emerging markets and industries, broadening their investment horizons

Quantile spillovers and connectedness between oil shocks and stock markets of the largest oil producers and consumers

This study explores the connectedness between major oil-producing and consuming countries' stock markets (United States, China, Russia, India) and different oil shocks categorized as demand, supply, and risk shocks, following Ready's (2018) framework. Employing a quantile-based connectedness approach and quantile cross-spectral dependence, our analysis spans from July 02, 2007 to May 31, 2023, encompassing diverse market conditions and events. These methodologies help identify interdependence patterns in extreme market scenarios at different time intervals. Key findings show variations in how these stock markets respond to oil shocks, depending on market conditions and quantiles. Demand-related shocks have the most significant spillover effects on the United States, Russia, and India, while risk-related shocks dominate as transmitters of shocks to the United States, China, and India in median quantiles. Market interconnectedness strengthens during extreme market conditions, reflecting historical events. Additionally, bearish markets offer diversification opportunities between these countries and crude oil. This study emphasizes the need for tailored investment strategies, monitoring global oil demand trends, dynamic portfolio management, crude oil inclusion in portfolios, and proactive responses to market players and geopolitical events. These insights benefit investors and policymakers seeking to optimize strategies in the interconnected global financial landscape.

Beyond N-Alkylation: Synthesis, Structure, and Function of N-Amino Peptides.

The growing list of physiologically important protein-protein interactions (PPIs) has amplified the need for compounds to target topologically complex biomolecular surfaces. In contrast to small molecules, peptide and protein mimics can exhibit three-dimensional shape complementarity across a large area and thus have the potential to significantly expand the "druggable" proteome. Strategies to stabilize canonical protein secondary structures without sacrificing side-chain content are particularly useful in the design of peptide-based chemical probes and therapeutics.Substitution of the backbone amide in peptides represents a subtle chemical modification with profound effects on conformation and stability. Studies focused on N-alkylation have already led to broad-ranging applications in peptidomimetic design. Inspired by nonribosomal peptide natural products harboring amide N-oxidations, we envisioned that main-chain hydrazide and hydroxamate bonds would impose distinct conformational preferences and offer unique opportunities for backbone diversification. This Account describes our exploration of peptide N-amination as a strategy for stabilizing canonical protein folds and for the structure-based design of soluble amyloid mimics.We developed a general synthetic protocol to access N-amino peptides (NAPs) on solid support. In an effort to stabilize β-strand conformation, we designed stitched peptidomimetics featuring covalent tethering of the backbone N-amino substituent to the preceding residue side chain. Using a combination of NMR, X-ray crystallography, and molecular dynamics simulations, we discovered that backbone N-amination alone could significantly stabilize β-hairpin conformation in multiple models of folding. Our studies revealed that the amide NH2 substituent in NAPs participates in cooperative noncovalent interactions that promote β-sheet secondary structure. In contrast to Cα-substituted α-hydrazino acids, we found that N-aminoglycine and its N'-alkylated derivatives instead stabilize polyproline II (PPII) conformation. The reactivity of hydrazides also allows for late-stage peptide macrocyclization, affording novel covalent surrogates of side-chain-backbone H-bonds.The pronounced β-sheet propensity of Cα-substituted α-hydrazino acids prompted us to target amyloidogenic proteins using NAP-based β-strand mimics. Backbone N-amination was found to render aggregation-prone lead sequences soluble and resistant to proteolysis. Inhibitors of Aβ and tau identified through N-amino scanning blocked protein aggregation and the formation of mature fibrils in vitro. We further identified NAP-based single-strand and cross-β tau mimics capable of inhibiting the prion-like cellular seeding activity of recombinant and patient-derived tau fibrils.Our studies establish backbone N-amination as a valuable addition to the peptido- and proteomimetic tool kit. α-Hydrazino acids show particular promise as minimalist β-strand mimics that retain side-chain information. Late-stage derivatization of hydrazides also provides facile entry into libraries of backbone-edited peptides. We anticipate that NAPs will thus find applications in the development of optimally constrained folds and modulators of PPIs.

Empowerment of SMEs And Entrepreneurial Ecosystems: a Qualitative Study on Diversifying Pattaya's Economy

Purpose: This qualitative study aims to explore how small and medium-sized enterprises (SMEs) and entrepreneurial ecosystems in Pattaya, Thailand, can empower the local economy to diversify beyond its traditional reliance on the tourism sector. It underscores the imperative of economic diversification for tourism-centric economies, especially in light of vulnerabilities exposed by global disruptions such as the COVID-19 pandemic. Method/Design/Approach: Employing a qualitative research design, the study utilizes in-depth interviews, focus groups, and participatory research methods with local entrepreneurs and stakeholders. This approach facilitates a comprehensive understanding of the experiences, strategies, and perceptions of those directly involved in Pattaya's SMEs and entrepreneurial ecosystems. Results and Conclusion: The research findings highlight a significant trend towards digital innovation and a reorientation towards local markets among Pattaya's SMEs. It uncovers the necessity for substantial investments in technology and digital infrastructure to enhance economic resilience and adaptability. Furthermore, the study accentuates the pivotal role of government in fostering an enabling environment through regulatory reforms, financial incentives, and infrastructure enhancements. The importance of educational initiatives in nurturing entrepreneurial skills and the critical involvement of the private sector and international organizations in supporting economic diversification efforts are also detailed. The conclusion posits that a collaborative, multi-stakeholder approach is vital for the sustainable economic development of Pattaya, moving beyond its traditional tourism-focused model. Originality/Value: This study contributes original insights into the challenges and opportunities for economic diversification in tourism-dependent economies, with a particular focus on Pattaya, Thailand. It offers valuable practical recommendations for SMEs, policymakers, and other stakeholders. Moreover, it underscores the importance of embracing digital transformation and fostering an entrepreneurial ecosystem as key strategies for achieving sustainable economic growth and resilience against global disruptions.