Fishers' are first-line observers of changes in the Sundarbans region and are among the first to be affected by the changes that occurred. In the Sundarbans fishers' communities, transformations of society have always been a part of life. In contrast, environmental changes were always interim and reversible, allowing them to understand and identify with the Sundarbans ecosystems as food and life providers. In this study, fishers' observations on climate change impacts and their livelihoods were compiled and analysed using a structured questionnaire in accordance with the tenets of grounded theory. The observations of fishers from the region of the Sundarbans demonstrated a rise in the frequency of extreme weather events caused by rising temperatures and changes in the weather pattern. Physical components such as rainfall, coastal erosion, sea-level rise, siltation alterations in fish species distribution ranges, and migratory spawning behaviours were also affected by changes in the region's weather and climate. As salinity levels rose, the diversity and productivity of river ecosystems were affected, particularly in the most vulnerable areas. As a result, river freshwater flow decreased over time. A high rate of siltation in rivers and river mouths was considered another major concern that led to seasonal flooding due to its low freshwater upstream flow rate. The Sundarbans region provides a vast array of resources for diversifying fishers' livelihoods, but climate change is diminishing these alternatives due to more frequent catastrophic events. Specifically, climate change limits the resilience of fishers' communities, restricting opportunities for diversification or forcing them to leave their homes or villages. Climate change generated an environment that was generally unfavourable for all fishing communities. In order to survive in an unfavourable environment, the social well-being of fishers (mostly women and children) was negatively impacted by a variety of challenges, including disease, lack of potable water, malnutrition, sanitary difficulties, lack of electricity, lack of food and clothing, lack of proper medical care, and so on. To evaluate the effects of climate change on fisheries in the study area, the biodiversity, abundance, and production of most freshwater species are drastically reduced due to the destruction of spawning grounds, a transition in the spawning season, and the obstruction of fish migration. The findings of this study show that the climate and livelihood conditions of fishers in the Sundarbans region have changed significantly over the past few decades. Regardless of GOs and NGOs taking the required steps, proper implementation of interdisciplinary adaptive policy and regular monitoring in the Sundarbans fisher's community in Bangladesh could effectively reduce climate change impacts and improve livelihood conditions. Asian J. Med. Biol. Res. 2022, 8 (2), 103-114
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