Background & Aim: Post the COVID-19 pandemic, there has been an observable escalation in the propensity of nurses to resign from their positions, which exerts substantial pressure on healthcare systems worldwide. Perceived Organizational Support has been acknowledged as a pivotal factor in the retention of nursing personnel after the pandemic. This study aims to provide valuable insights into the intricate interplay between Perceived Organizational Support, Psychological Well-being, Organizational Commitment, and Nurses’ Intention to Stay in Vietnamese healthcare. Methods & Materials: This study adopted a cross-sectional quantitative design using a structured questionnaire to collect data from diverse professionals in Vietnam through an online platform. Data analysis was conducted using PLS-SEM on a robust dataset of 302 valid observations. A hybrid sampling method combining convenience and snowball techniques was employed. The questionnaire was disseminated via Google Forms during March and April 2024, allowing for an insightful examination of the research phenomena within Vietnam's unique sociocultural context. Results: The study showed a significant positive impact of Perceived Organizational Support on Psychological Well-being, Organizational Commitment, and Nurses’ Intention to Stay. Perceived Organizational Support directly affects Nurses’ Intention to Stay, and Psychological Well-being emerges as a strong determinant of Nurses’ Intention to Stay and a mediator between Perceived Organizational Support and Nurses’ Intention to Stay. Conclusion: Healthcare managers play a key role in promoting Nurses’ Intention to Stay by increasing Organizational Support, promoting Psychological Well-being, and enhancing Organizational Commitment. These strategies are critical to maintaining stability within the healthcare organization, addressing nursing turnover, and maintaining a resilient workforce.