Anchored stabilizing piles (ASPs) are widely used as excavation support systems in slope anti-seismic reinforcement engineering. In this study, a set of centrifuge contrast tests were designed and used to explore the influence of the anchor angle on the seismic response of the system to further deepen the research on the seismic response of ASPs. To this end, the effects of two anchor cable arrangement angles on the slope seismic response, lateral dynamic earth pressure, anchor cable axial force, and pile dynamic moment were compared and analyzed. The results show that changing the angle of anchor cable arrangement can reduce the degree of seismic damage to the slope and the settlement of the slope top (up to a maximum reduction of 77%) and, to some extent, reduce the amplification of acceleration inside the slope. Under seismic action, the different angles of anchor cables do not change the distribution of seismic earth pressure and peak dynamic bending moment but can significantly affect their magnitude and growth rate. The appropriate arrangement angle of the anchor cable can effectively slow the growth of the internal force of the anchor cable and reduce the risk of anchor cable failure. The anchor cable is not the main load-bearing component in an ASP but the primary component that limits pile displacement. Overall, this study can provide a detailed data foundation for subsequent centrifuge comparative tests and parameter analysis.