Particle Diameter Distribution Research Articles

PVP/aprepitant microcapsules produced by supercritical antisolvent process

The supercritical antisolvent (SAS) process was a green alternative to improve the low bioavailability of insoluble drugs. However, it is difficult for SAS process to industrialize with limited production capacity. A coaxial annular nozzle was used to prepare the microcapsules of aprepitant (APR) and polyvinylpyrrolidone (PVP) by SAS with N, N-Dimethylformamide (DMF) as solvent. Meanwhile, the effects of polymer/drug ratio, operating pressure, operating temperature and overall concentration on particles morphology, mean particle diameter and size distribution were analyzed. Microcapsules with mean diameters ranging from 2.04 μm and 9.84 μm were successfully produced. The morphology, particle size, thermal behavior, crystallinity, drug content, drug dissolution and residual amount of DMF of samples were analyzed. The results revealed that the APR drug dissolution of the microcapsules by SAS process was faster than the unprocessed APR. Furthermore, the drug powder collected every hour is in the kilogram level, verifying the possibility to scale up the production of pharmaceuticals employing the SAS process from an industrial point of view.

Using enzymatic synthesis of hydroxyapatite as a technique to develop materials for biomedical applications

Composite materials based on gels and hydroxyapatite could provide promising characteristics for biomedical materials because of biocompatibility, osteointegration, and easy implementation. In this research, enzymatic synthesis of hydroxyapatite was studied as a technique for tissue engineering and scaffolds creation. The hydroxyapatite crystals were synthesized using this method and characterized with X-ray diffraction, electron microscopy, IR and Raman spectroscopy and analytical methods. As a result, a material with assumed composition of Ca10−x(HPO4)x(PO4)6−x(OH)2−x/CaHPO4/CaCO3 was obtained by enzymatic synthesis. The dynamics of size evolution, texture and crystallinity of the solid phase as a function of deposition time were also investigated. Afterwards, this method was used for gel mineralization with hydrogels such as agarose, alginate, gelatin, and polyacrylamide. Hydroxyapatite crystals obtained inside and above the hydrogels were analyzed with X-ray diffraction and electron microscopy. The particle diameter distribution functions were used to evaluate the mineralization in different gels. The shape and size of mineral inclusions depend on the density of the hydrogel grid. The localization of the formed solid phase depends on the nature of the gel and the concentration of alkaline phosphatase inside it. The results provide an opportunity to control the morphology of calcium phosphate particles produced during mineralization, which is important for the creation of biomedical materials with specified and reproducible characteristics.

Моделирование эрозионного износа титанового сплава высокоскоростным потоком частиц

Introduction. Predicting solid particle erosion (SPE) in gaseous flow and managing its intensity is still a relevant problem in mechanical engineering. It requires the development of a general modeling methodology, which also depends upon many special cases studying various physical processes. Such studies should also include verification analysis, process parameters and model sensitivity studies. Mainly computational fluid dynamics and finite element analysis (and mesh-free methods such as smooth particle hydrodynamics or similar) are used to simulate the erosion process. Papers focused on CFD simulation of solid particle erosion of metal alloys are widely presented, but most of it is associated with relatively low or medium particle velocities (< 100–150 m/s) and is close to uniform diameter distribution. This paper presents a CFD study of Ti6Al4V titanium alloy SPE at relatively high particle velocities and sufficiently non-uniform unimodal particle diameter distribution. The paper also studies the turbulence model influence and particle shape effect which appears as a “shape factor” coefficient in the particle drag model. Methods. The heterogenous flow simulation was based on the Reynolds-averaged Navier-Stokes formulation, where the particles, according to Euler-Lagrange formulation, were simulated as mathematical points with corresponding properties. The influence of turbulence models, such as k-epsilon standard, RNG k-epsilon, and a relatively new Generalized equation k-omega (GEKO) model and its coefficients were also studied. Oka and DNV erosion models were also compared based on the general sample mass loss and more specific erosion intensity profile criterions. The simulation results were compared to the lab-scale experimental results. Results and discussion. It is shown that neither erosion intensity profile or sample mass loss do not depend upon the turbulence model choice or GEKO parameters variation. As expected, erosion is dependent on the erosion model and its coefficients. A notable influence of the shape factor is shown. As the drag coefficient increased due to the particle shape, the erosion intensity decreased and the erosive profile on the surface also changed due to the changing velocity and diameter distribution of the heterogenous flow. It is expected that such results would be useful not only for erosion prediction in all areas of mechanical engineering, but also for wear management in mechanical assemblies and shot peening / shot peen forming management and simulation.

Elucidating the modified performance of high nuclearity of Cu nanostructures-PTFE thin film

The aim of this study is to attain an extensive insight on the performance mechanism that is associated with the formation of Cu nanostructures- polytetrafluoroethylene (PTFE) thin film. The work presented Cu nanostructures synthesised via microwave-assisted method at different Cu precursor concentrations to observe the influence of different average particle diameter distribution, {d}_{m} of Cu nanostructures on the fabricated Cu nano thin film. The thin films of Cu nanostructures with a layer of PTFE were fabricated using the Meyer rod coating method. Evaluating the effect of Cu nanostructures at different {d}_{m} with overcoated PTFE layer showed that the resistance of fabricated thin film coated with PTFE is not significantly different from that of the uncoated thin film. The results implicate the influence of the PTFE layer towards the output performance, which can maintain a stable and constant resistance over time without affecting the original properties of pure Cu nanostructures, although some of the Cu nanostructures seep into the layer of PTFE. The novelty of this study lies in the effect of the intrinsic interaction between the layer of Cu nanostructure and PTFE, which modulate the performance, especially in photovoltaic cell application.

The influences of diameter distribution change of zeolitic imidazolate framework‐67 crystal on electrochemical behavior for lithium‐sulfur cell cathode

To improve the electrochemical performance of Li‐S batteries, sulfur composites are prepared through sulfur's melt‐diffusion into porous materials such as metal organic frameworks (MOFs). MOFs are porous nanocrystalline materials consisting of metal ions and organic ligands. Due to their high porosity, specific surface area, and easily controllable porous structure, MOFs and their derivatives are considered useful materials for holding sulfur. Herein, the effect of the concentration of the reactants on the particle diameter distribution of ZIF‐67 is studied, and the performance of the product as a sulfur host for Li‐S battery cathode is evaluated. ZIF‐67 was prepared by regulating the Co2+ concentration in solution from 10 to 250 mM, with a constant mole ratio between Co2+ and the organic ligand. Cyclovoltammetry, galvanostatic charge–discharge, and rate capability tests were performed to electrochemically characterize each sample as a sulfur host for Li‐S battery cathodes. MeZ‐50 mM, prepared with 50 mM Co2+ ion solution, had the smallest particle diameter (591 nm). The sulfur cathode utilizing MeZ‐50 mM afforded the best electrochemical performance (883.7 mAh gS−1). This study demonstrates that the particle size of ZIF‐67 can be controlled by adjusting the reactant concentration, enabling manipulation of the electrochemical properties as a sulfur host.

A computational study of particle dynamics in synthetic jet flow field

This computational study aims to investigate the transport and dispersion of solid particles in a synthetic jet flow field. Solid spherical particles were injected into the jet at a single point, and their behavior was observed until they left the domain. The interaction between the particles and the vortex rings in the jet was compared for synthetic jets, with different Strouhal numbers (0.05, 0.1, and 0.2). The Reynolds number (Re = 150), the mass of injected particles, particle diameter distribution, and particle Stokes number at injection were kept constant. The results showed that the jet's momentum mainly transported the particles, while the vorticity of the vortex rings caused them to spread. The particle Stokes number affected the distribution of particles within the jet, with a higher Stokes number particle concentrating at the jet's center and lower Stokes number particles being carried within the vortex ring. For the low Strouhal number jet, the combined effect of the fast decline in the particle Stokes number, low vorticity of vortex ring, significant distance between successive vortices, and high jet momentum resulted in a higher spread of particles and rapid transport across the domain. As the Strouhal number increased, the particle Stokes number decreased slowly downstream; moreover, the vorticity of the vortex ring increased, the distance between vortices decreased, and low momentum imparted by the jet led to less particle spread and slower transport. Overall, the spread and transport of particles were most effective in the synthetic jet, with the low Strouhal number.

Influence of Block-Copolymers' Composition as Compatibilizers for Epoxy/Silicone Blends.

The objective of this study was to prepare crosslinked epoxy networks containing liquid silicone particles in order to improve their mechanical properties and obtain less brittle materials. Different copolymers were used as compatibilizers. These copolymers vary in their chemical composition and structure. All of the copolymers contain hydrophobic (PDMS sequences) and hydrophilic groups. The effect of their chemical structure and architecture on the morphology of the dispersed phase, and on the final physico-chemical and flexural characteristics of epoxy/silicone blends, was explored. The morphology of crosslinked formulations was studied by scanning electron microscopy (SEM), and the thermal characteristics (glass transition temperature, Tg, and curing exothermic peak) were determined by differential scanning calorimetry (DSC). The experimental results have shown that the average diameter and particle size distribution of silicone particles depend on the chemical structure and architecture of the compatibilizers. One copolymer has been identified as the best compatibilizer, allowing a lower mean diameter and particle size distribution in addition to the best mechanical properties of the final network (less brittle character). This study has consequently evidenced the possibility of creating in situ silicone capsules inside an epoxy network by adding tailored compatibilizers to epoxy/silicone formulations.

Experimental investigation on centrifugal granulation of molten yellow phosphorus slag

Centrifugal granulation with waste recovery was proposed to recover the waste heat from the molten yellow phosphorus slag produced by an electric arc furnace and reduce pollution. The yellow phosphorus slag was heated to the same temperature as industrial electric furnaces and then granulated by centrifugal granulation. The study mainly investigated the effect of operating parameters on particle diameter distribution, flight distance distribution, and fiber mass fraction during the granulation process. The results showed that the average diameter was mainly 1.5–3 mm, and tended to decrease with the decrease of the mass flow rate, the increase of the rotating speed, and the increase of the rotary cup diameter. The particle diameter obeyed a log-normal distribution. As the rotating speed increased and the rotary cup diameter increased, the average flight distance and the distribution of flight distance were dispersed. The average flight distance was related to the linear velocity at the edge of the rotary cup. Increasing slag temperature, mass flow rate, and decreasing rotary cup diameter can reduce the fiber mass fraction. Re and We numbers can determine whether fibers produce.

Vapor Exchange Induced Particles‐Based Sponge for Scalable and Efficient Daytime Radiative Cooling

AbstractPassive daytime radiative cooling technology (DRCT) has recently gained significant attention for its ability to achieve sub‐ambient temperature without energy consumption, making it an attractive option for space cooling. The cooling performance can be further improved if radiative cooling materials also exhibit high thermal insulation performance. However, synthesizing radiative cooling materials that possess low thermal conductivity while maintaining mechanical durability remains a challenge. Here, a vapor exchange method is developed to prepare particles‐based poly(vinylidene fluoride‐co‐hexafluoropropylene) sponge materials for scalable and efficient daytime radiative cooling. By tailoring the particle diameter distribution, high solar reflection (94.5%), high infrared emissivity (0.956), and low thermal conductivity (0.048 W m−1 K−1) are achieved, resulting in a sub‐ambient cooling of 9.8 °C under direct solar irradiation. Additionally, the sponge material exhibits good mechanical durability, sustaining deformation with a strain up to 40%, making it adaptable to diverse scenarios. A radiative cooling material with mechanical durability and thermal insulation can thus pave the way for large‐scale applications of DRCT.

Population balance modeling of InP quantum dots: Experimentally enabled global optimization to identify unknown material parameters

Despite great progress in the synthetic chemistry of InP QDs, a predictive model to describe their temporal formation is still missing. In this work, we introduce a population balance model incorporating liquid phase reactions, homogeneous nucleation and reaction-limited growth of InP supported with the highly reproducible and reliable experimental data acquired from an automated robotic synthesis platform. A comparison between experimental kinetic data (different initial concentrations and temperatures) and simulations was made. The proposed model describes the temporal evolution of solid concentration, particle diameter and particle size distribution very well. The quantitative agreement between experiments and simulations was only achieved by global optimization to identify unknown and hardly measurable material parameters and kinetic constants such as surface energy, growth rate constants or activation energies. We see this model rendering the first step towards the development of more refined models that enable rigorous optimization and control of the production process for III-V semiconductors.

Development of a method of evaluating PuO2 particle diameters using an alpha-particle imaging detector.

It is very important to evaluate the diameters (activity median aerodynamic diameter) of plutonium dioxide (PuO2) particles for internal exposure dose evaluation. In this study, a method of evaluating PuO2 particle diameters using an alpha-particle imaging detector was developed. PuO2 particles with different diameters were modeled by Monte Carlo simulation, and the change in the shape of the energy spectrum for each particle diameter was evaluated. Two different patterns were modeled, namely, the case of 239PuO2 and the case of PuO2 (including isotopic composition of Pu). Multiple regression analysis was performed to determine the PuO2 particle diameter from the obtained parameters. The simulated diameters and the diameters obtained with the regression model were in good agreement. The advantage of using the alpha-particle imaging detector is to measure the alpha energy spectrum for individual particle, and this allows accurate measurement of particle diameter distribution.

Synthesis of gold nanoparticles in emulsion–emulsion precipitation route: Experiment, mechanism and simulation

Soft templates like water-in-oil emulsion drops (of 1-100μm diameter), have been used for synthesis of nanoparticles; with specific mean particle diameter and narrow particle size distribution. In this context, two separate emulsions have been reacted by an emulsion–emulsion precipitation route. Consequently, two different kinds of interacting populations coexist — emulsion drops evolving through drop coalescence and breakage, with multiple nanoparticle populations growing inside each emulsion drop. However, no model framework currently exists to simulate these two highly interacting populations, for predicting evolution of nanoparticle size. To this end, presently gold nanoparticles (GNPs) have been used as a model system, to explore the nanoparticle formation mechanism. The metal salt precursor and reducing agent (NaBH4 or N2H4) are prepared in two separate water-in-oil emulsions and are reacted upon mixing to form GNPs. A kinetic Monte Carlo (kMC) scheme accounting for drop coalescence, drop breakage, nucleation, particle growth and particle–particle coagulation was developed to handle simultaneous size and number evolution of aqueous emulsion drops and GNP populations. We find that, the mean GNP diameter decreases (from 6.9 to 3.5 nm) with increasing molar ratio (M) of reducing agent to precursor concentration. Further, increasing the precursor concentration at a fixed M, does not affect the final particle size. Our kMC simulation results not only agree well with experimental mean particle diameter and coefficient of variation (COV) of particle diameter, but was also validated with full particle size distribution of GNPs. So, M can be used as a tunable parameter for controlling GNP diameter experimentally.

Investigating the effects of initial concentration and population distribution on the transport of aggregating nanoparticles in porous media

In order to investigate the migration of nanoparticles in porous media, the model developed by Katzourakis and Chrysikopoulos (2021) is applied to simulate the transport of aggregating nanoparticles under various initial conditions. In the aforementioned model, nanoparticles may collide with each other and form larger particle structures with different mobility and reactivity characteristics. Individual particles as well as aggregates can be found suspended in aqueous phase or attached, reversibly and/or irreversibly, on the solid matrix. The aggregation process modelled after the Smoluchowski population balanced equation (PBE), is coupled with the conventional advection-dispersion-attachment (ADA) equation to form a system of coupled equations that govern the transport of aggregating nanoparticles. Particle collisions are expected to increase exponentially with increasing initial number of injected particles (N0). Therefore, substantially pronounced aggregation is expected when N0 is increased. Similarly, the initial particle diameter distribution of the injected particles is expected to affect the average size of aggregates and in turn influence their mobility in a porous medium. Several model simulations were performed with different N0 and particle diameter distributions. The results indicated the strong importance of taking into account the initial particle concentration and realistic particle diameter population distribution into consideration.

Quantitative analysis of layered re-crushing of crushed coal particles during compression based on CT scanning

Due to the compaction of the overburden strata, the crushed coal in caved zone will be re-crushed. The compaction and re-crushing degree of crushed coal differ at different heights, which is called layered re-crushing. Quantitatively revealing the layered re-crushing characteristics of crushed coal particles is the key to elucidating pore structure evolution of caved zone and coalbed methane enrichment pattern in the gob. In this paper, quantitative characterization of layered re-crushing of coal particles during compression is achieved using self-designed CT visual compacting apparatus. The results showed that: (1) the degree of particle re-crushing decreased from the loaded side (the upper layer) to the fixed side (the lower layer). In the early stage of compression, the overall skeletal structure is looser, which is not conducive to the transfer of force chains. Thus, the stress has the greatest effect on the particles in the upper layer, with the proportion of particle increase reaching 49.3% from 0 Mpa to 2.14 Mpa. There was a pattern of becoming larger first and then smaller in the difference of average diameter among different layers, and the final average diameter decreased by about 60% in three layers. (2) The particle diameter distribution transferred to a smaller diameter fastest in the upper layer and slowest in the lower layer, which is due to the gradual transfer of external load from the top to the bottom. After compression, the number of particles smaller than 4 mm predominated in the upper layer (40.3%) and the number of particles larger than 5 mm predominated in the lower layer (47.1%). (3) With the increase of stress, the void volume gradually decreases regardless of the whole sample or the three layers, while the void number increases instead. And at both 2.14 MPa and 23.24 MPa, the void volume shows the law of upper layer < middle layer < lower layer.

Secondary Motion of Non-Spherical Particles in Gas Solid Flows

Objective of this study is to investigate the effect of secondary motion of particles in multiphase gas-solid flows parametrically and test the relative impacts of particle shape and orientation information on particle distribution. For that purpose, predictive accuracies of simplified drag coefficient models are assessed for the conditions relevant to a wood recovery plant operating at dilute flow regime. After demonstrating the strong impact of the shape and orientation information on the force balance for single particles, we compared the steady state Eulerian-Lagrangian simulation results for particle volume fractions, residence times and particle diameter distributions within the chamber for different (i) superficial gas velocities (5 m/s, 7.5 m/s), (ii) orientation tendencies and (iii) particle shapes. Transient simulations are performed until the system reaches steady state conditions by monitoring the mass flow rates of the particulate phases leaving the chamber. The secondary motion of non-spherical particles is represented by stochastic sampling from the available experimental data. Analysis of the force balance on single particles revealed log-scale variations if the orientation of the particles with respect to flow fluctuates. Variations in the single particle force balances are found to be still visible in the CFD analysis, where the secondary motion of particles drastically changed the particle distribution in the chamber. The native non-spherical model which only accounts for the shape correction was found to over-predict the entrainment, leading to a significantly different particle volume fraction and diameter distributions. Spherical particle assumption also caused significant errors in the particle distribution, which increases as aspect ratio of the cylindrical particle diverges from one. Results show that particle orientation statistics are extremely important to capture the particle mixing and segregation patterns at dilute regime, which cannot be captured with such simplifying assumptions.

Numerical study on the phase change and spray characteristics of liquid ammonia flash spray

Ammonia is regarded as one of the carbon-free alternative fuels for energy systems. The direct utilization of liquid ammonia in gas turbines can reduce the complexity and start-up time of the system. Liquid ammonia is susceptible to flash boiling because of its low boiling point, especially under standard conditions. The boiling point is 239.7 K under 1 atm, which is different from those of traditional hydrocarbon fuels and brings challenges for liquid ammonia spray and combustion simulation. However, the validity of phase-change models for liquid ammonia remains unclear and needs further exploration. Therefore, the present work aims to numerically evaluate the existing evaporation and boiling models for liquid ammonia flash spray. Large eddy simulations were conducted in the Euler-Lagrangian framework, considering droplet kinetics, evaporation, boiling, radiation, and gas-particle interactions. Specifically, five phase-change models were evaluated by comparing the simulation results with recently published experimental data for the vaporization of the ammonia flash spray in terms of the penetration length, spray morphology, and temperature-diameter distribution law. The results indicated that the combined model (the Zuo model combined with the Langmuir-Knudsen model) was more suitable under superheated conditions and agreed reasonably with the experimental results obtained under various temperature and pressure conditions. The evaporation rate tended to increase with decreasing pressure, leading to a significant reduction in the droplets and gas field temperatures. The interaction between the droplet and gas phases was significantly affected by pressure. The ammonia vapor mass fraction first decreased and then increased with an increase in temperature under low pressure, whereby it exhibited only a positive correlation at high ambient pressure. Finally, the effect of the particle diameter distribution was explored and discussed.

Сонохимическое микроструктурирование альгината натрия для повышения его эффективности в технологии хлебобулочных изделий

Algae are a source of many biologically active compounds that can be used in food production to expand the range of functional products. For instance, sodium alginate possesses a complex of scientifically proven biologically active properties. In the food industry, it usually serves as a thickener, stabilizer, gelatio n agent, and water-retaining agent. The biological activity of this polysaccharide and its effect on the technological properties of food systems depend on the molecular weight and particle size uniformity. The present research objective was to study the method of sonochemical microstructuring of sodium alginate to increase its biological activity and efficiency as part of v arious bakery formulations.&#x0D; The research featured alginate gels, yeast suspensions of Saccharomyces cerevisiae, and bakery products. The sonochemical microstructuring of sodium alginate involved a low-frequency ultrasonic treatment at 240, 435, and 630 W/L and 50°C for 20, 25, and 30 min. The effect of the treatment included the following indicators: particle morphology vs. distribution of the hydrodynamic particle diameter in a dispersed medium, antioxidant activity, dynamic viscosity, in vitro bioactivity, and bioavailability against Paramecium caudatum and S. cerevisiae. The quality assessment of bakery products followed State Standard 58233-2018.&#x0D; The process of sonochemical microstructuring depolymerized large particles of sodium alginate into shorter ones: 5670 nm – 30.6%, 502 nm – 53.4%, 56.1 nm – 16%. It increased the antioxidant activity by 7 times and the potential in vitro bioactivity by 3.9%. The microstructured sodium alginate improved the fermentation activity of S. cerevisiae and reduced the yeast biomass by 8%. The resulting bakery products had a greater porosity by 5.9% and antioxidant activity by 3.7 times.&#x0D; The sonochemical microstructuring reduced the particle size of sodium alginate, as well as increased its biological activity. The sonochemically microstructured sodium alginate demonstrated a great potential for baked foods.

Mitochondrial-derived vesicles retain membrane potential and contain a functional ATP synthase.

Vesicular transport is a means of communication. While cells can communicate with each other via secretion of extracellular vesicles, less is known regarding organelle-to organelle communication, particularly in the case of mitochondria. Mitochondria are responsible for the production of energy and for essential metabolic pathways in the cell, as well as fundamental processes such as apoptosis and aging. Here, we show that functional mitochondria isolated from Saccharomyces cerevisiae release vesicles, independent of the fission machinery. We isolate these mitochondrial-derived vesicles (MDVs) and find that they are relatively uniform in size, of about 100 nm, and carry selective protein cargo enriched for ATP synthase subunits. Remarkably, we further find that these MDVs harbor a functional ATP synthase complex. We demonstrate that these vesicles have a membrane potential, produce ATP, and seem to fuse with naive mitochondria. Our findings reveal a possible delivery mechanism of ATP-producing vesicles, which can potentially regenerate ATP-deficient mitochondria and may participate in organelle-to-organelle communication.

芽胞形成細菌に対するオゾンウルトラファインバブル混合液の殺菌効果

In this study, antimicrobial effect of mixed ultra-fine bubble liquids on two types of bacteria; spore-forming bacteria (Bacillus subtilis var. natto) and the environmental bacteria was investigated. We used ultrapure water (UPW), mixed ultra-fine bubble water (UFB), mixed ultra-fine ozone-rich bubble water (UFORB), and water containing ozone (OZ). Viable bacteria count (VBC) of UFB agreed with that of UPW within the experimental errors (p < 0.05). Low VBC (High effect) of UFORB and OW exhibited on B. subtilis var. natto. Moreover, complete sterilization of UFORB was obtained on the environmental bacteria. For discussing the experimental results, we observed number density against particle diameter, effect of dilution and elapsed time after stopped the ultra-fine bubble generator. Difference between UFB and UFORB exhibited in case of distribution of particle diameter (peak diameter and averaged diameter). The bactericidal effect on B. subtilis var. natto persisted after 360 min (6 h), but disappeared after 1440 min (24 h). On the other hand, the bactericidal effect against the environmental bacteria was high even after 1440 min (24 h).

Experimental and numerical investigation on the performance of a gas-solid cyclone with twisted baffles and roughened cone surface

This paper presents a numerical and experimental study of a gas-solid cyclone to improve its performance by employing twisted baffles with a variable pitch length and roughened cone surface. Three-dimensional numerical simulations are performed utilizing ANSYS FLUENT software by employing the Reynolds Stress Model (RSM) and Eulerian-Lagrangian particle tracking scheme for the distribution of particle diameters from 0.1 to 14 μm. Numerical results demonstrate that the baffles have a major effect on the effective parameters of the cyclone such as tangential and axial velocities, turbulence intensity, pressure drop, the three-dimensional structure of eddies, and particle separation efficiency. It is found that the maximum amounts of tangential velocity, axial velocity, and separation efficiency correspond to 3-turn twisted baffles. With the installation of baffles, the generated vortices become stronger, enhancing the turbulence intensity and pressure drop compared to the case without baffles. The results reveal that the presence of baffles results in an enhancement in the separation efficiency of solid particles with a diameter of fewer than 2 μm. For the case of 3-turn twisted baffles and the inlet velocity of 30 m/s, the separation efficiency of particles with a diameter of 0.1 μm is >40%, indicating the proper performance of the device. In the present work, a cyclone with a 3-turn twisted baffle is fabricated and tested. The experimental results confirm the numerical results appropriately and demonstrate that the separation efficiency reaches 80% for the inlet velocity of 5.9 m/s.