The present study is aimed at understanding and thoroughly documenting the complex unsteady fluid dynamics in six generations of a model human bronchial tree, comprising 63 straight sections and 31 bifurcation modules, during a complete breathing cycle. The computational task is challenging since the complexity of an elaborate network is augmented with adopted stringent criteria for spatial and temporal accuracy and convergence at each time step (10−8 for each scaled residual). The physical understanding of the fluid dynamics of steady expiratory flow is taken to a similar level of fine details that have been previously established for steady inspiratory flow in earlier publications of the authors. The effects of three-dimensional arrangement of the same branches on the oscillatory flow structure are determined. It is found that the quasisteady assumption is approximately valid in the neighborhood of the peak flow rate, both during inspiration and expiration. Unsteady effects are at their maximum during the changeover from expiration to inspiration and inspiration to expiration. At these time instants, regions of bidirectional flow are observed in all branches with significant secondary motion at various cross sections (none of these features can be predicted by steady state simulations). It is described how the symmetry of the solution with respect to both space and time—found in the oscillating, fully developed flow in a pipe—are destroyed in the unsteady effects that occur in the oscillating flow in a branching network. As the Womersley number is increased, the unsteady effects at all branches increase, and bidirectional flow exists over a greater portion of a cycle. The flow division at a bifurcation module during inspiratory flow generates large asymmetry in the flow field with nonuniform mass flow distribution among the branches of a generation (even in a geometrically symmetric network), whereas flow combination at the same bifurcation module during expiratory flow tends to produce more symmetry in the flow field, displaying essential irreversibility of fluid dynamics.
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