Strong earthquakes can not only trigger many landslides in a short period of time but can also change the stability of slopes in the earthquake area, causing them to be active for a long time after the earthquake. Research on the variation of slow-motion slopes before and after earthquakes can help us to better understand the mechanism of earthquake-affected landslides, which is also crucial for assessing the long-term landslide risk in seismically active areas. Here, L-band ALOS-2 PALSAR-2 images are utilized with the SBAS-InSAR algorithm to monitor and assess the location and activity changes of slow-moving landslides in the Iburi region (Hokkaido, Japan) before and after an earthquake occurred on 6 September 2018. Unlike previous studies, which focused on single typical landslides, we tracked all the landslides within a 33 × 55 km region close to the epicenter. According to the results, the majority of the co-seismic landslides that quickly failed during the earthquake are now stable, and a few of them are still moving. In contrast, due to near-field seismic shaking, certain slopes that did not show substantial surface changes during the earthquake period continued to move and eventually developed into slow-moving landslides. In addition, it can be seen from the spatial distribution of slow-moving landslides after the earthquake that this distribution is not only dependent on strong earthquake seismic vibration or the hanging-wall effect. Far-field weak vibrations can also accelerate landslides. Additionally, we discovered that the earthquake made the unstable slopes move more quickly but also tended to stabilize the slopes that were already in motion before the earthquake. The various response modes of slow-moving landslides to seismic events are related not only to the intensity of seismic vibration but also to the geological conditions of the region and to the size of the landslide itself. These findings are extremely valuable for studying the mechanism of earthquake-affected landslides.